Why is "Calcium-sensing receptor" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-23 08:31:28
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Calcium-sensing_receptor entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-23 and was most recently seen on 2026-08-23.
Wikipedia Overview
The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions. It is primarily expressed in the parathyroid gland, the renal tubules of the kidney, pancreatic islets and the brain. In the parathyroid gland, it controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). In the kidney, it has an inhibitory effect on the re-absorption of calcium, potassium, sodium, and water depending on which segment of the tubule is being activated. CaSR has regulatory role in insulin secretion, adhesion and beta-cell proliferation in pancreatic islets.
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Trending Topic Today
Search Interest Perspective
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The many roles of the calcium-sensing receptor in the kidney - American Physiological Society Journal
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Autosomal Dominant Hypocalcemia With Hypercalciuria Due to a Calcium-Sensing Receptor Gain-of-Function Mutation: A Pediatric Case Report - Cureus
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Zebrafish casr modulates cardiac structure and function - Nature
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Stimulation of basolateral calcium-sensing receptor inhibits Kir4.1/Kir5.1 in the mouse distal convoluted tubule - American Physiological Society Journal
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Regulation of the WNK4-SPAK-NCC pathway by the... : Current Opinion in Nephrology & Hypertension - Ovid
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Research progress on cellular behavior of CaSR in cardiovascular diseases - Frontiers
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Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist - Science | AAAS
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The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases - Nature
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secretion in intestinal epithelial cells via calcium-sensing receptor - American Physiological Society Journal
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Promiscuous G-protein activation by the calcium-sensing receptor - Nature
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Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion - Nature
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The calcium-sensing receptor has only a parathyroid hormone-dependent role in the acute response of renal phosphate transporters to phosphate intake - American Physiological Society Journal
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Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients | BJC Reports - Nature
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Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges - Nature
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Distinct and targetable role of calcium-sensing receptor in leukaemia - Nature
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Advances in calcium-sensing receptor modulation: biased signaling and therapeutic potential - Nature
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Asymmetric activation of the calcium-sensing receptor homodimer - Nature
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Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis - Nature
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Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway - Nature
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Oral expressions and functional analyses of the extracellular calcium-sensing receptor (CaSR) in chicken - Nature
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Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca - Nature
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Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex | Cell Research - Nature
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The Calcium-Sensing Receptor and Integrins in Cellular Differentiation and Migration - Frontiers
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Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor - Science | AAAS
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Cryo-EM structure of the calcium-sensing receptor complexed with the kokumi substance γ-glutamyl-valyl-glycine - Nature
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Calcium-Sensing Receptor: A Key Target for Extracellular Calcium Signaling in Neurons - Frontiers
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Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells - Nature
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Association of common variants in the calcium-sensing receptor gene with serum calcium levels in East Asians - Nature
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The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR - Nature
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The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future - Frontiers
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Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function - PNAS
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Activation profile of the Atlantic salmon ( Salmo salar ) calcium-sensing receptor (Casr) by selected L-amino acids - Nature
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Calcium-sensing receptor in nutrient sensing: an insight into the modulation of intestinal homoeostasis - Cambridge University Press & Assessment
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Clinical lessons from the calcium-sensing receptor - Nature
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Analysis of Calcium Sensing Receptor Variants - Endocrine Society
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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor - Nature
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The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal Development - Science | AAAS
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Illuminating the allosteric modulation of the calcium-sensing receptor - PNAS
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Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor - Nature
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Goreisan promotes diuresis by regulating the abundance of aquaporin 2 phosphorylated at serine 269 through calcium-sensing receptor activation - Nature
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How a Calcium-Sensing Protein Multitasks - Columbia University Irving Medical Center
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Novel Role of the Calcium-Sensing Receptor in Blood Pressure Modulation - American Heart Association Journals
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Peptide Blocking Self-Polymerization of Extracellular Calcium-Sensing Receptor Attenuates Hypoxia-Induced Pulmonary Hypertension - American Heart Association Journals
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Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice - Baishideng Publishing Group
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Acquired Hypocalciuric Hypercalcemia Due to Autoantibodies against the Calcium-Sensing Receptor - NEJM
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Associations of the calcium-sensing receptor gene CASR rs7652589 SNP with nephrolithiasis and secondary hyperparathyroidism in haemodialysis patients - Nature
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Immunolocalization of the calcium-sensing receptor in developing human kidney - Nature
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Seizures in activating calcium-sensing receptor antibodies positive autoimmune hypoparathyroidism and preponderance of steroids therapy: A case report - Wiley Online Library
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Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma - Science | AAAS
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Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR) - ScienceDirect.com
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-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells - Nature
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Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals - Nature
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Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer - Nature
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Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca - Wiley Online Library
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Dysregulation of STS in keratinocytes promotes calcium signaling and differentiation - Nature
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Spontaneous Glutamate Release Is Independent of Calcium Influx and Tonically Activated by the Calcium-Sensing Receptor - Journal of Neuroscience
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Genetic variants of calcium and vitamin D metabolism in kidney stone disease - Nature
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Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia - NEJM
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Cinacalcet for Symptomatic Hypercalcemia Caused by AP2S1 Mutations - NEJM
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Multifaceted calcium sensing receptor - CORDIS | European Commission
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Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages - Nature
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Olive Leaf Extract (OLE) impaired vasopressin-induced aquaporin-2 trafficking through the activation of the calcium-sensing receptor - Nature
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A Familial Syndrome of Hypocalcemia with Hypercalciuria Due to Mutations in the Calcium-Sensing Receptor - NEJM
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Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice - PLOS
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Control of blood calcium concentration by renal CaSR - Nature
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The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism - Nature
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Autosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2 - Frontiers
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Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways - Nature
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Atypical skeletal manifestations of rickets in a familial hypocalciuric hypercalcemia patient - Nature
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Cinacalcet for Symptomatic Hypercalcemia Caused by AP2S1 Mutations - NEJM
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Autoimmune Hypocalciuric Hypercalcemia - Endocrine Society
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Mechanism of calcitriol regulating parathyroid cells in secondary hyperparathyroidism - Frontiers
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Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease | Scientific Reports - Nature
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L-Amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? | European Journal of Clinical Nutrition - Nature
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In vivo treatment with calcilytic of CaSR knock-in mice ameliorates renal phenotype reversing downregulation of the vasopressin-AQP2 pathway - Wiley & Sons
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l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents | International Journal of Obesity - Nature
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Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor - Nature
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-Sensing Receptor Mutation Causes Hypoparathyroidism by Increasing Receptor Sensitivity to Ca - Nature
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The CaSR/TRPV4 coupling mediates pro‐inflammatory macrophage function - Chen - 2023 - Acta Physiologica - Wiley Online Library
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Severe Symptomatic Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia - Cureus
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Familial hypocalciuric hypercalcemia: An atypical presentation - www.elsevier.com
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Comparison of human chromosome 19q13 and syntenic region on mouse chromosome 7 reveals absence, in man, of 11.6 Mb containing four mouse calcium-sensing receptor-related sequences: relevance to familial benign hypocalciuric hypercalcaemia type - Nature
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Treatment of Autosomal Dominant Hypocalcemia Type 1 With the Calcilytic NPSP795 (SHP635) - Wiley Online Library
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is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors - Nature
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Extracellular calcium sensing and signalling - Nature
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Autosomal Dominant Hypocalcemia Type 1: A Systematic Review - Wiley Online Library
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An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations - PNAS
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Research reveals molecular mechanism of asymmetric calcium-sensitive receptor activation - Phys.org
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Hypercalciuria revisited: one or many conditions? - Springer Nature Link
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The Central Role of Phosphate: 50 Years of Research and Discovery in Chronic Kidney Disease and Mineral & Bone Disorder - Renal and Urology News
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New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium–Sensing Receptor - Science | AAAS
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Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell | Scientific Reports - Nature
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Autosomal Dominant Hypocalcemia in Monozygotic Twins Caused by a De Novo Germline Mutation Near the Amino-Terminus of the Human Calcium Receptor - Wiley Online Library
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Hipercalcemia hipocalciúrica familiar. A propósito de dos casos - scielo.isciii.es
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Hipercalcemia hipocalciúrica familiar: a veces no es lo que parece - scielo.isciii.es
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.