Why is "Calcineurin" trending?

Search Interest Perspective

• The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment - Nature
• Diverse effects of calcineurin in vascular smooth muscle cells: physiological activators and the controversial actions of clinical inhibitors - Frontiers
• Delayed and Recurrent Calcineurin Inhibitor–Induced Psychosis With Agents in the Same Class and in the Absence of Supratherapeutic Levels - Psychiatrist.com
• Calcineurin Inhibitors Compared for Lupus Nephritis - Renal and Urology News
• Calcineurin-Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata - Wiley & Sons
• Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata - ASM Journals
• Targeting of Cdc42‐Interacting Protein 4‐Calcineurin Signalosomes Improves Cardiac Structure and Function After Myocardial Infarction - American Heart Association Journals
• Calcineurin Inhibitor–Free GVHD Prevention Post Transplant Yields Strong Results - Targeted Oncology
• PMSA as a potential modulator of calcineurin phosphatase activity - Nature
• Calcineurin Inhibitors Market Size to Hit USD 20.88 Billion by 2035 - Precedence Research
• Calcineurin Inhibitors and Their Black Box Warnings in Pediatric AD - Contemporary Pediatrics
• Immunosuppression without calcineurin inhibition: by ZEUS - The Lancet
• Calcineurin/NFAT Pathway Links Calcium Stress to Neurodegeneration Timing - Bioengineer.org
• Which Vitiligo Therapy Combinations Are Most Effective? - Physician's Weekly
• Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata - ASM Journals
• A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin - Nature
• Putting the Brakes on Cardiac Hypertrophy: TMC6 Controls the CIB1-NFAT Axis | Circulation Research - American Heart Association Journals
• RCAN1-Mediated Calcineurin Impairment Drives Sympathetic Outflow in Hypertension | Circulation Research - American Heart Association Journals
• The treatment based on calcineurin inhibitors and their conversion to sirolimus alter the morphology in the rat testis - Nature
• Postsynaptic competition between calcineurin and PKA regulates mammalian sleep–wake cycles - Nature
• Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc - Nature
• Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR - PNAS
• phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies - Nature
• Calcineurin inhibitors’ impact on cardiovascular and renal function, a descriptive study in lung transplant recipients from the North of Spain | Scientific Reports - Nature
• Correlation between dietary salt intake and renal outcomes related to calcineurin inhibitor nephrotoxicity in kidney transplant recipients - Nature
• Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome - Wiley & Sons
• Calcineurin targets that mediate Cryptococcus thermotolerance - PNAS
• Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons - Journal of Neuroscience
• Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM - Nature
• The optimized core peptide derived from CABIN1 efficiently inhibits calcineurin-mediated T-cell activation - Nature
• Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin - PNAS
• Calcineurin Controls Hypothalamic NMDA Receptor Activity and Sympathetic Outflow - American Heart Association Journals
• Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane - Nature
• Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB - Nature
• Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents - Nature
• Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy - PNAS
• Targeting calcineurin induces cardiomyocyte proliferation in adult mice - Nature
• CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis - Nature
• Rationale for the Use of Topical Calcineurin Inhibitors in the Management of Oral Lichen Planus and Mucosal Inflammatory Diseases - Cureus
• Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect - Nature
• Calcineurin/NFATc1 pathway represses cellular cytotoxicity by modulating histone H3 expression - Nature
• A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes - Nature
• Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning - Nature
• Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy | Circulation - American Heart Association Journals
• Ca2+-Induced Apoptosis Through Calcineurin Dephosphorylation of BAD - Science | AAAS
• A second calcineurin binding site on the NFAT regulatory domain - PNAS
• Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling - American Heart Association Journals
• A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides - ASM Journals
• Cyclophosphamide, Calcineurin Inhibitors Equally Effective for Pediatric Nephrotic Syndrome - HCP Live
• Calcineurin Promotes Neuroplastic Changes in the Amygdala Associated with Weakened Cocaine-Cue Memories - Journal of Neuroscience
• A critical role of calcineurin in stress responses, hyphal formation, and virulence of the pathogenic fungus Trichosporon asahii - Nature
• Non-Immunologic Actions of Calcineurin Inhibitors in Proteinuric Kidney Diseases - Frontiers
• Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder - Nature
• Association of high intra-patient variability in tacrolimus exposure with calcineurin inhibitor nephrotoxicity in kidney transplantation - Nature
• Thrombotic microangiopathy associated with calcineurin inhibitor induction doses in patients with a kidney transplant - Wiley Online Library
• Calcineurin Aβ–Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy | Circulation - American Heart Association Journals
• Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling - Nature
• Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy - Journal of Neuroscience
• Reduced Exposure to Calcineurin Inhibitors in Renal Transplantation - The New England Journal of Medicine
• Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD - CancerNetwork
• myeloid cells is crucial for intestinal immune homeostasis - Nature
• The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction - American Heart Association Journals
• The calcineurin-responsive transcription factor Crz1 regulates the expression of CMK2 via a sole CDRE site in its promoter in budding yeast - Nature
• Calcineurin inhibitors in lupus nephritis - Springer Nature Link
• Nephrotoxicity of Calcineurin Inhibitors in Kidney Epithelial Cells is Independent of NFAT Signaling - Frontiers
• Calsarcins, a novel family of sarcomeric calcineurin-binding proteins - PNAS
• A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants - ScienceDirect.com
• The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension - Nature
• RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2 - Nature
• RANK promotes colorectal cancer migration and invasion by activating the Ca - Nature
• Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration - Frontiers
• Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin - Nature
• Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway - Nature
• Ca2+, Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases - Frontiers
• Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes - PNAS
• Calcineurin inhibition, cardiovascular consequences, vascular resistance, and potential responses - Wiley Online Library
• ATP sulfurylase atypical leucine zipper interacts with Cys3 and calcineurin A in the regulation of sulfur amino acid biosynthesis in Cryptococcus neoformans - Nature
• Sugarcane calcineurin B-like ( CBL ) genes play important but versatile roles in regulation of responses to biotic and abiotic stresses - Nature
• Cooperative autoinhibition and multi-level activation mechanisms of calcineurin - Nature
• Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy - Nature
• Regulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells - Nature
• Calcineurin regulates cyclin D1 stability through dephosphorylation at T286 - Nature
• Epithelial calcineurin controls microbiota-dependent intestinal tumor development - Nature
• Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? - Frontiers
• Piezo1 modulates autophagy of HT22 neurons. - PLOS
• Novel calcineurin A ( PPP3CA ) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression - Nature
• SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation - Nature
• Topical Calcineurin and PDE-4 Inhibitors in the Treatment of AD - HCP Live
• Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury - Journal of Neuroscience
• Balancing Graft Survival and Neural Outcomes: Insights From a Systematic Review of Tacrolimus-Induced Neurotoxicity - Cureus
• Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition - Science | AAAS
• Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo - PNAS
• Calcineurin Bound — A New Mechanism to Help Explain Heart Failure - Stanford Medicine
• Calcineurin Controls Voltage-Dependent-Inactivation (VDI) of the Normal and Timothy Cardiac Channels - Nature
• Topical Calcineurin Inhibitors for AD Not Associated With Cancer - The American Journal of Managed Care
• Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress - Nature
• The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin - Science | AAAS
• Recruitment of calcineurin to the TCR positively regulates T cell activation - Nature
• Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4 - Nature
• Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice - Journal of Neuroscience