Why is "CXCL1" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-07-14 00:09:44
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
CXCL1 entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-07-14 and was most recently seen on 2026-07-14.
Wikipedia Overview
The chemokine ligand 1 (CXCL1) is a small peptide belonging to the CXC chemokine family that acts as a chemoattractant for several immune cells, especially neutrophils or other non-hematopoietic cells to the site of injury or infection and plays an important role in regulation of immune and inflammatory responses. It was previously called GRO1 oncogene, GROα, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MGSA-α). CXCL1 was first cloned from a cDNA library of genes induced by platelet-derived growth factor (PDGF) stimulation of BALB/c-3T3 murine embryonic fibroblasts and named "KC" for its location in the nitrocellulose colony hybridization assay. This designation is sometimes erroneously believed to be an acronym and defined as "keratinocytes-derived chemokine". Rat CXCL1 was first reported when NRK-52E cells were stimulated with interleukin-1β (IL-1β) and lipopolysaccharide (LPS) to generate a cytokine that was chemotactic for rat neutrophils, cytokine-induced neutrophil chemoattractant (CINC). In humans, this protein is encoded by the gene CXCL1 and is located on human chromosome 4 among genes for other CXC chemokines.
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Trending Topic Today
Search Interest Perspective
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Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer - Nature
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Triple-Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis - Wiley & Sons
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ETV7 promotes 5-FU resistance and malignant progression through CXCL1-induced NETs formation in colorectal cancer - Nature
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Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme - Science | AAAS
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Scientists uncover how support cells, once thought harmless, send damaging signals that weaken the heart - Medical Xpress
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IL7R remodels immunosuppression tumor microenvironment and promotes macrophage polarization by regulating NF-κB/CXCL1 axis in ovarian cancer - Nature
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Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration - Science | AAAS
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Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells - Nature
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Unraveling the Role of METTL3 in Helicobacter pylori-induced gastritis via m6A-CXCL1/NF-κB modulation - Nature
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Temporal expression of CXCR2 ligands in a rat model of LPS—induced pulpitis - Nature
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Blocking the CXCL1-CXCR2 axis enhances the effects of doxorubicin in HCC by remodelling the tumour microenvironment via the NF-κB/IL-1β/CXCL1 signalling pathway | Cell Death Discovery - Nature
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Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs - Nature
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Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions - Nature
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CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling - Nature
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The role of CXCL family members in different diseases - Nature
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CAF-secreted CXCL1 conferred radioresistance by regulating DNA damage response in a ROS-dependent manner in esophageal squamous cell carcinoma | Cell Death & Disease - Nature
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neutrophils recruited by CXCL1 delay denervated skeletal muscle atrophy and undergo P53-mediated apoptosis - Nature
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CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment - Nature
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Kupffer cell-derived TNF-α promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells - Nature
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Expression of CXCL1 in human endothelial cells induces angiogenesis through the CXCR2 receptor and the ERK1/2 and EGF pathways - Nature
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Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1 - Nature
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Human nasal turbinate stem cells with specific gene signatures ( HAS2 CXCL1 KRTAP1-5 GSTT2B , and C4B ) attenuate rheumatoid arthritis - Nature
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Mycobacterium tuberculosis -triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses - Nature
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RETRACTED ARTICLE: Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection - Nature
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Clinical Association of Chemokine (C-X-C motif) Ligand 1 (CXCL1) with Interstitial Pneumonia with Autoimmune Features (IPAF) - Nature
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The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response - Frontiers
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NLRP12 modulates host defense through IL-17A–CXCL1 axis - Nature
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Biomarkers of ulcerative colitis disease activity CXCL1, CYP2R1, LPCAT1, and NEU4 and their relationship to immune infiltrates - Nature
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TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways - Nature
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microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment - Nature
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The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression - Nature
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Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade | British Journal of Cancer - Nature
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Pentagalloyl glucose inhibits TNF α activated CXCL1/GRO-α expression and induces apoptosis related genes in triple-negative breast cancer cells - Nature
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Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF) - Nature
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A TLR–CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice - Nature
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Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis - Nature
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Increase in chemokine CXCL1 by ERβ ligand treatment is a key mediator in promoting axon myelination - PNAS
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circRNF13, a novel N6-methyladenosine-modified circular RNA, enhances radioresistance in cervical cancer by increasing CXCL1 mRNA stability | Cell Death Discovery - Nature
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Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization - Nature
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Neutrophil-sourced TNF in cancer: deciphering an intricate orchestrator of immunosuppressive communication in the tumor microenvironment - Nature
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Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling - Nature
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Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch - Nature
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Intratumor Fusobacterium nucleatum promotes the progression of pancreatic cancer via the CXCL1-CXCR2 axis - Wiley Online Library
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Hepatic stellate cell-released CXCL1 aggravates HCC malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis - Wiley Online Library
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Basophils stoke the fire - Nature
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Silencing of O-linked N-acetylglucosamine transferase ameliorates hypercalcemia-induced neurotoxicity in renal failure by regulating EZH2/KLF2/CXCL1 axis - Nature
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C‐X‐C motif chemokine ligand 1 induced by Hedgehog signaling promotes mouse extrahepatic bile duct repair after acute injury - Wiley Online Library
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IL-17A drives a fibroblast-neutrophil-NET axis to exacerbate immunopathology in the lung with diffuse alveolar damage - Frontiers
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Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling - Nature
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PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow - Nature
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IRF5 controls both acute and chronic inflammation - PNAS
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Phospholipase Cɛ has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC | Laboratory Investigation - Nature
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A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis - Wiley Online Library
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Canonical NF-κB signaling pathway and GRO-α/CXCR2 axis are activated in unruptured intracranial aneurysm patients - Nature
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Discovery of potent and orally bioavailable IL-17A inhibitors for the treatment of psoriasis - BioWorld News
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Neutrophils Found to Be Culprits in Treatment-Resistant Pancreatic Cancer - Genetic Engineering and Biotechnology News
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Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice - Nature
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Functional Distinction between CXC Chemokines, Interleukin-8 (IL-8), and Growth Related Oncogene (GRO)α in Neutrophil Infiltration - Nature
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Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation - Nature
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CXCR2/CXCR2 Ligand Biological Axis Impairs Alveologenesis During dsRNA-Induced Lung Inflammation in Mice - Nature
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A combined biomarker panel shows improved sensitivity and specificity for detection of ovarian cancer - Wiley Online Library
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Potential Therapy against Opioid Tolerance - spotlight - National Taiwan University - ntu.edu.tw
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A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.