Why is "CRISPR activation" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-24 15:46:17
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
CRISPR_activation entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-24 and was most recently seen on 2026-08-24.
Wikipedia Overview
CRISPR activation (CRISPRa) is a genetic perturbation technique that utilizes an engineered form of the CRISPR-Cas9 system to enhance the expression of specific genes without altering the underlying DNA sequence. Unlike traditional CRISPR-Cas9, which introduces double-strand breaks to edit genes, CRISPRa employs a modified, catalytically inactive Cas9 (dCas9) fused with transcriptional activators to target promoter or enhancer regions, thereby boosting gene transcription. This method allows for precise control of gene expression, making it a valuable tool for studying gene function, creating gene regulatory networks, and developing potential therapeutic interventions for a variety of diseases.
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Trending Topic Today
Search Interest Perspective
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High-content CRISPR activation screens identify synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity - Nature
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CRISPR activation screens identify oncogenic lncRNAs that are susceptible to CDK4/6 inhibitor treatment - Nature
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Programmable multistep CRISPR gene activation via control of RNA polymerase III termination - Science | AAAS
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CRISPR activation: identifying and using novel genes for plant disease resistance breeding - Frontiers
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CRISPR Activation Restores SCN2A Loss, Improves Neurodevelopmental Outcomes in Mice - Genetic Engineering and Biotechnology News
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Scientists report first use of CRISPR activation to treat a cardiac disease in mice - Medical Xpress
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CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice - Science | AAAS
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CRISPR activation: quicker diagnosis of rare genetic diseases - Drug Target Review
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Accelerated reprogramming of hiPSCs into functional brain endothelial-like cells using multiplexed CRISPR activation - Nature
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From GWAS signal to function: targeted CRISPR activation enables functional characterization of non-coding SNPs in chickens - Frontiers
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CRISPR activation for SCN2A -related neurodevelopmental disorders - Nature
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A systematic screening assay identifies efficient small guide RNAs for CRISPR activation - Frontiers
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In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis - Science | AAAS
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A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation - Nature
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A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis - Science | AAAS
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Development of a CRISPR activation system for targeted gene upregulation in Synechocystis sp. PCC 6803 - Nature
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Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes - Nature
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CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity - Nature
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Validation of CRISPR activation system in Aedes cells using multicistronic plasmid vectors - Frontiers
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Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance - Nature
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A versatile, high-efficiency platform for CRISPR-based gene activation - Nature
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Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery - Nature
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Uncovering receptor-ligand interactions using a high-avidity CRISPR activation screening platform - Science | AAAS
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CRISPR Screen Uncovers ARL11 as Key Determinant in PARP Inhibitor Resistance - CRISPR Medicine News
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Effective Transcriptional Induction of the CARMN/miR-143/145 Complex Locus in Smooth Muscle Cells Using CRISPR Activation - American Heart Association Journals
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Discovery of stimulation-responsive immune enhancers with CRISPR activation - Nature
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CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants - American Heart Association Journals
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Genome-scale CRISPR activation screen uncovers tumor-intrinsic modulators of CD3 bispecific antibody efficacy - Nature
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CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma - Nature
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CRISPRa-activated Genes are Silenced in Differentiated Cells - CRISPR Medicine News
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Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems - Nature
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Functional genetic characterization of stress tolerance and biofilm formation in Nakaseomyces Candida glabrata via a novel CRISPR activation system - ASM Journals
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Tamoxifen controls gene activation with CRISPRa/i - CRISPR Medicine News
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Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes - Nature
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Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements - Nature
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Mouse medulloblastoma driven by CRISPR activation of cellular Myc - Scientific Reports - Nature
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Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria - Nature
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Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation - Nature
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Boosting SCN2A expression reduces seizures in mice - The Transmitter
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Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice - Nature
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Study could pave the way for better diagnosis of rare genetic diseases - Det Sundhedsvidenskabelige Fakultet - Aarhus Universitet
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Manipulating Gene Expression in Neurons with CRISPR - Neuroscience News
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.