Why is "CD4" trending?

Search Interest Perspective

• Supercentenarians have a cellular superpower - Scientific American
• People Who Live Past 100 Have a Surprising Abundance of Cancer-Killing Immune Cells - ScienceAlert
• CD4+ T cells impair tumor growth through IL-3 and TNF-dependent vascular damage - Science | AAAS
• Fc-optimized GITR antibody enhances a CD4 T cell–dendritic cell crosstalk to promote antitumor immunity - Nature
• Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease - PNAS
• Rare Immune Cell Type in Supercentenarians May Help Maintain Healthy Aging - Genetic Engineering and Biotechnology News
• Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza - Rockefeller University Press
• Supercentenarians have an abundance of cancer-killing immune cells - Medical Xpress
• People who live past 110 share a surprising immune system trait - Earth.com
• B1a Cell-IgM Axis Protects Against Hypertension by Blunting IFNγ+CD4+T Cells - American Heart Association Journals
• MHC class I on target cells regulates CD4+ T cell-mediated immunity - Nature Immunology - Nature
• Treg cells promote immunotherapy-induced immune evasion by restraining CD4 T cell control of MHC-I–deficient metastatic pancreatic cancer - Science | AAAS
• Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection - Nature
• Intestinal epithelial MHC class II induces encephalitogenic CD4 T cells and initiates central nervous system autoimmunity - Science | AAAS
• A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation - Nature
• TH1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata - Science | AAAS
• Generation and characterization of humanized CD4 knock-in mice expressing chimeric mouse/human CD4 protein - Nature
• A long-lived ‘killer’ role emerges for CD4 cells - Nature
• The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC - Nature
• Dysfunctional CD4 T cells in an oncovirus-specific TCR-transgenic in vivo model - Nature
• Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells - Science | AAAS
• Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice - Nature
• Pyruvate kinase muscle 2 (PKM2) promotes CD4 T cell survival by regulating pyruvate oxidation during homeostasis and expansion - Science | AAAS
• T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy - Nature
• Persistent antigen is essential for sustaining Leishmania major–specific memory CD4+ T cells and long-term immunity - Science | AAAS
• CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging - Nature
• CD4 Count and Routine Laboratory Parameters in Neurological Manifestations of HIV: A Secondary Analysis of Their Diagnostic Utility - Cureus
• Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis - Wiley Online Library
• Low CD4 Count Tied to Cervical Cancer Risk in HIV Infection - Medscape
• Commentary: Increased circulating Th17 cells and altered CD4 T cell maturation and differentiation in active tuberculosis with type 2 diabetes: a pilot study - Frontiers
• Hybrid immune cells help supercentenarians over 110 maintain longevity - 동아사이언스
• CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes | Circulation - American Heart Association Journals
• A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells - Frontiers
• Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines - ASM Journals
• Use of the novel PanLeucogated CD4 test has saved over 600 million USD for South Africa’s HIV treatment programme: A 20-year retrospective costing analysis (2004 to 2024) - medRxiv
• Three Republicans vie for chance to beat Horsford in CD4 - Nevada Current
• What helps some people live past 110? Study finds unusual ‘killer’ immune cells - ThePrint
• Evaluation of point-of-care Alere Pima CD4 test for low CD4 cell counts test in Uganda - Nature
• Human CD4+ T cells recognize Mycobacterium tuberculosis–infected macrophages amid broader responses - Rockefeller University Press
• Supercentenarians Aged 110+ Have Four Times More Special Immune Cells That Kill Cancer Cells - finance.biggo.com
• Research suggests that centenarians have a higher concentration of rare immune cells that kill cancer cells. - GIGAZINE
• Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines - ASM Journals
• CD3+CD4−CD8− T cells: a new potential therapeutic target in treating autoimmune diseases - Frontiers
• Differentiation fate of a stem-like CD4 T cell controls immunity to cancer - Nature
• Reappraisal of Idiopathic CD4 Lymphocytopenia at 30 Years - The New England Journal of Medicine
• Early and opposing neutrophil and CD4 T cell responses shape pulmonary tuberculosis pathology - Rockefeller University Press
• A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs - Nature
• Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease - Nature
• Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection? - Frontiers
• CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours - Nature
• Good CD4 cell recovery linked to lower cancer risk for people with HIV - European AIDS Treatment Group
• Chronic inflammation degrades CD4 T cell immunity to prior vaccines in treated HIV infection - Nature
• CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer - Frontiers
• HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes - Nature
• CD4 expression controls epidermal stem cell balance - Nature
• Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma - Nature
• Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice - Nature
• CD4+T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions - Nature
• Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein - Nature
• Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration - Nature
• Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence - Nature
• Intermediate conformations of CD4-bound HIV-1 Env heterotrimers - Nature
• Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity - Nature
• CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity - Science | AAAS
• Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature
• T cells in cancer - Nature
• Structural basis of CD4 downregulation by HIV-1 Nef - Nature
• Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development - Rockefeller University Press
• Engineered CD4 T cells for in vivo delivery of therapeutic proteins - PNAS
• Tonsillar cytotoxic CD4 T cells are involved in the control of EBV primary infection in children - Nature
• Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting - Nature
• Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer - Nature
• Age and CD4 count have the greatest influence on life expectancy in the modern HIV treatment era - Aidsmap
• Effect of CD4 count on Mycobacterium tuberculosis infection rates in people living with HIV: a comparative study in prison and community - Nature
• Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice - Nature
• Clonal Follicular CD4+ T Cells Adapt Across Lymph Nodes and Lung Tumors - Bioengineer.org
• Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians - PNAS
• Characteristics of differentiated CD8(+) and CD4 (+) T cells present in the human brain - National Institutes of Health (NIH) | (.gov)
• Inadequate CD4 recovery linked to more clinical events - European AIDS Treatment Group
• Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening - Nature
• Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA - Nature
• Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway - Nature
• Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer - Science | AAAS
• Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo - Nature
• Lower chances of survival for people whose CD4 count remains under 500, Polish researchers report - Aidsmap
• CD4+ T cell dysfunction in cancer - Rockefeller University Press
• Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV - The New England Journal of Medicine
• Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis - Frontiers
• Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses - Science | AAAS
• CD4 cell lymphopenia and atherosclerosis in renal transplant recipients - National Institutes of Health (NIH) | (.gov)
• double-positive T cells characterized by single-cell RNA sequencing - Nature
• Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule - PNAS
• Helper T cell immunity in humans with inherited CD4 deficiency - Rockefeller University Press
• Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes - Science | AAAS
• CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies - ASM Journals
• B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM - Rockefeller University Press
• PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors - Science | AAAS
• Point-of-care CD4 tests to support the identification of individuals with advanced HIV disease - World Health Organization (WHO)
• Robustness of viral load over CD4 cell count in measuring the quality of life of people with HIV at second line regimen in Amhara region - Nature
• Differentiation and Transmigration of CD4 T Cells in Neuroinflammation and Autoimmunity - Frontiers