Why is "CD28" trending?

Search Interest Perspective

• Comparable restimulation of human T cells activated with CD3/CD28 beads versus soluble antibody complexes - Nature
• Roswell Park Team Provides First Direct Evidence of CD28 Effects on CAR T-Cell Therapy - Roswell Park Comprehensive Cancer Center
• Henlius Showcases HLX3902 Preclinical Data at AACR 2026, Highlighting Its CD28-Enabled Multispecific TCE Platform - 复宏汉霖
• A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands - Nature
• This immune circuit may protect the brain from Alzheimer's - The Rockefeller University
• Researchers Identify Predictors of Response to CAR T-Cell Therapy in B-Cell Non-Hodgkin’s Lymphoma - Cleveland Clinic
• REGN5668 Combo Yields Preliminary Activity in Recurrent Ovarian/Endometrial Cancer - CancerNetwork
• Brain’s Immune Cells Found to Protect Against Alzheimer’s Damage - Neuroscience News
• Scientists find brain cells that could stop Alzheimer’s - ScienceDaily
• The €500mn hole in Chernobyl’s roof - Financial Times
• CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclusters | Communications Biology - Nature
• Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation - PNAS
• PD-1 protects expanding human T cells from premature restimulation-induced cell death by modulating TCR and CD28 signaling | Cell Death & Disease - Nature
• CD28 co-stimulatory domain enhances efficacy of CER T cell therapy compared to 4-1BB in an ovarian cancer mouse model - Nature
• Targeting of CD28 and CD38 as a potential novel therapeutic strategy for peripheral T-cell lymphomas - Nature
• Prognostic value of CD28⁻CD57⁺CD8⁺ T cells for early immunotherapy response in hepatocellular carcinoma: a prospective observational study - Nature
• Lymphoid gene expression supports neuroprotective microglia function - Nature
• CD28 co-stimulation: novel insights and applications in cancer immunotherapy - Nature
• Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation - Nature
• T cells in patients with lung cancer blunts responses to immune checkpoint inhibitor therapy - Nature
• B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms - Nature
• CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity | Cellular & Molecular Immunology - Nature
• Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T cells - Science | AAAS
• CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder | Communications Biology - Nature
• A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains - Nature
• H-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer - Nature
• Rational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy - Nature
• Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance - Rockefeller University Press
• The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity - Nature
• Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy - Science | AAAS
• A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 - Nature
• Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells - Nature
• CAR T-Cell Therapy: Is CD28-CAR Heterodimerization Its Achilles’ Heel? - Frontiers
• Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells - Nature
• CD8+CD28- T cells: not only age-related cells but a subset of regulatory T cells - Nature
• Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency - Rockefeller University Press
• CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-κB subunits on IL-8 and Bcl-xL gene promoters - PNAS
• CD28 and CD3 have complementary roles in T-cell traction forces - PNAS
• Recent advancements in the B7/CD28 immune checkpoint families: new biology and clinical therapeutic strategies - Nature
• BACH2-mediated CD28 and CD40LG axes contribute to pathogenesis and progression of T-cell lymphoblastic leukemia - Nature
• Interaction of the Wiskott–Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells - PNAS
• Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2 - Nature
• Thymic resident NKT cell subsets show differential requirements for CD28 co-stimulation during antigenic activation - Nature
• NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ - PNAS
• CTLA4-CD28 chimera gene modification of T cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy - Nature
• Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not T - Nature
• Dynamic regulation of CD28 conformation and signaling by charged lipids and ions - Nature
• T-cell regulation by CD28 and CTLA-4 - Nature
• Superagonistic CD28 stimulation induces IFN-γ release from mouse T helper 1 cells in vitro and in vivo - Wiley Online Library
• Regeneron rethinks CD28 bispecific R&D plan after 2 patients die - Fierce Biotech
• Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412 - The New England Journal of Medicine
• CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm - Nature
• CD28 and ITK signals regulate autoreactive T cell trafficking - Nature
• CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse - Frontiers
• Persistence of peripheral CD8 + CD28− T cells indicates a favourable outcome and tumour immunity in first-line HER2-positive metastatic breast cancer | British Journal of Cancer - Nature
• Stronger and faster is not always better - Fred Hutchinson Cancer Center
• CD28-costimulated CD19 CAR-T cells for pediatric mature non-Hodgkin B-cell lymphoma - Nature
• The B7–CD28 superfamily - Nature
• Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation - Frontiers
• CD28-mediated co-stimulation: a quantitative support for TCR signalling - Nature
• Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling - Nature
• Expamers: a new technology to control T cell activation - Nature
• T Cell Effector Function through the Augmentation of CD28 Costimulation - Science Partner Journals
• Human mesenchymal stromal cells enhance the immunomodulatory function of CD8 - Nature
• CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells | Communications Biology - Nature
• Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins - Nature
• Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response - Nature
• Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor - Nature
• CD8+ CD28− regulatory T cells after induction therapy predict progression-free survival in myeloma patients: results from the GMMG-HD6 multicenter phase III study | Leukemia - Nature
• c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation - Nature
• Naïve CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells - PNAS
• Identification of potential new T cell activation molecules: a Bioinformatic Approach - Nature
• Crystal structure of a soluble CD28-Fab complex - Nature
• mice depends on a specific CD28 motif that is required for in vivo costimulation - PNAS
• Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity - Nature
• Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway - Science | AAAS
• CAR NK cells with CD28 costimulation improved cell persistence and antitumor activity - UT MD Anderson
• Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells - Science | AAAS
• Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity - Nature
• A silver bullet for ageing medicine?: clinical relevance of T-cell checkpoint receptors in normal human ageing - Frontiers
• Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor - PNAS
• Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors - PNAS
• T cell response in myeloid antigen-presenting cell niches - Nature
• The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells - Nature
• CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 - Nature
• Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412 - The New England Journal of Medicine
• The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells - Nature
• The immunological synapse and CD28-CD80 interactions - Nature
• Cbl-b regulates the CD28 dependence of T-cell activation - Nature
• Hollings researcher challenges the current CAR-T-cell design to improve immunotherapy options - The Medical University of South Carolina
• 16MB049 aAPC: Artificial Antigen-Presenting Cells expressing CD3, CD28 and a Heparin-Binding Domain for Producing CAR-Ts - Moffitt
• PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation - Frontiers
• Investigating T-Cell Receptor Dynamics Under In Vitro Antibody-Based Stimulation Using Imaging Flow Cytometry - Wiley Online Library
• 2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses - Rockefeller University Press
• Cancer immunotherapy: Revived T cells still need fuel - Medical Xpress
• PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors - Frontiers
• Rondo Therapeutics Announces Collaboration with Lilly to Develop Novel CD28 Bispecific Antibodies for Solid Tumors - Business Wire
• Expression of CD28, FAS, PD1, and CTLA4 molecules in the blood of women with triple-negative breast cancer - Wiley Online Library
• CTLA4 prohibits T cells from cross-dressing - Rockefeller University Press
• Regulation of Lck activity by CD4 and CD28 in the immunological synapse - Nature