Why is "CD154" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-28 22:17:24
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
CD154 entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-28 and was most recently seen on 2026-05-28.
Wikipedia Overview
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibits antibody affinity maturation, an important process in the adaptive immune system.
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Trending Topic Today
Search Interest Perspective
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The CD40-CD154 axis in transplantation: from immunobiology to therapeutic targeting - Frontiers
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Tonix Pharmaceuticals Announces Publication of Phase 1 Clinical Data of TNX-1500, an Fc-Modified anti-CD40L (CD154) Monoclonal Antibody, in the Peer-Reviewed Journal of Clinical Immunology - GlobeNewswire
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Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs - Nature
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Platelet CD154 Potentiates Interferon-α Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus - Science | AAAS
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Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a - PNAS
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Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems - Wiley & Sons
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The Inhibition of CD40/CD154 Costimulatory Signaling in the Prevention of Renal Transplant Rejection in Nonhuman Primates: A Systematic Review and Meta Analysis - Frontiers
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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates - Nature
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Dual intracellular staining of CD154 (CD40L) and cytokines at single-cell level: A novel aid to document immediate hypersensitivity to amoxicillin - Wiley Online Library
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Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade - PNAS
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CD154 Expression Indicates T Cell Activation Following Tetanus Toxoid Vaccination of Horses - Frontiers
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Therapeutic effects of anti-CD154 antibody in cynomolgus monkeys with advanced rheumatoid arthritis - Nature
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CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis - Wiley Online Library
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Peripheral deletion of mature alloreactive B cells induced by costimulation blockade - PNAS
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Requirement for CD154 in the progression of atherosclerosis - Nature
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Unique and common TCR repertoire features of Ni2+‐, Co2+‐, and Pd2+‐specific human CD154 + CD4+ T cells - Wiley Online Library
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Alloreactive CD154-expressing T-cell subsets with differential sensitivity to the immunosuppressant, belatacept: potential targets of novel belatacept-based regimens - Nature
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IgE‐mediated bleomycin hypersensitivity: Evidence from drug‐reactive T lymphocytes - Wiley Online Library
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BAFF upregulates CD28/B7 and CD40/CD154 expression and promotes mouse T and B cell interaction in vitro via BAFF receptor - Nature
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T cells specific for defined antigens according to CD154 expression - Nature
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Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion - The Lancet
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Xenotransplantation Moving Closer to Becoming a Clinical Reality - Pulmonology Advisor
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Manipulated Microenvironment in Human Papilloma Virus–Infected Epithelial Cells: Is the CD40–CD154 Pathway Beneficial for Host or Virus? - ScienceDirect.com
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A late Pleistocene dataset of Agulhas Current variability - Nature
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Flow‐cytometric analysis of rare antigen‐specific T cells - Bacher - 2013 - Cytometry Part A - Wiley Online Library
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Rapid and efficient nonviral gene delivery of CD154 to primary chronic lymphocytic leukemia cells - Nature
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Design and functionality of the N-CD expression cassette cloned into the lentiviral plasmid pl6twblast. - PLOS
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Immune properties of recombinant vaccinia virus encoding CD154 (CD40L) are determined by expression of virally encoded CD40L and the presence of CD40L protein in viral particles - Nature
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Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model - Wiley Online Library
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Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi - Nature
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Mechanistic Rationale for Dual Costimulation Blockade, Belatacept, Dazodalibep in Kidney Transplantation - HCP Live
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Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells - Nature
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Gene transfer of CD154 and IL12 cDNA induces an anti-leukemic immunity in a murine model of acute leukemia - Nature
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Sanofi, Immunext partner to develop autoimmune therapies - BioPharma Dive
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Dual Costimulation Blockade May Eliminate Daily Oral Immunosuppression in Kidney Transplant - HCP Live
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Rationale for CD40 pathway blockade in autoimmune rheumatic disorders - The Lancet
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Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T - Nature
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Encouraging Results for Gene Therapy in CLL - CancerNetwork
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The food colorant erythrosine is a promiscuous protein–protein interaction inhibitor - ScienceDirect.com
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Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development - PNAS
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Improving Prostate Cancer Diagnosis with Dual-Target Imaging - Johns Hopkins Medicine
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The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates - Science | AAAS
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Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation - Nature
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Chronic inflammation degrades CD4 T cell immunity to prior vaccines in treated HIV infection - Nature
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Kiniksa launches Phase 2b clinical trial of abiprubart in Sjögren’s - Sjogren's Disease News
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Identifying Molecular Culprits Underlying Organ Rejection - Northwestern University
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T cells targeting renally expressed antigens in human lupus nephritis with two independent methods - Nature
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Eastern South African hydroclimate over the past 270,000 years - Nature
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Spontaneous restoration of transplantation tolerance after acute rejection - Nature
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Xenotransplantation of 10GE Pig Kidneys to NHPs Shows Consistent Survival - genengnews.com
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Targeting the HA2 subunit of influenza A virus hemagglutinin via CD40L provides universal protection against diverse subtypes - Nature
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The Expression of CD40 on Monocytes of Children with Primary Humoral Immunodeficiencies - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.