Why is "C3a (complement)" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-15 15:11:29
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
C3a_(complement) entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-15 and was most recently seen on 2026-08-15.
Wikipedia Overview
C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response.
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Trending Topic Today
Search Interest Perspective
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The Role of Complement Anaphylatoxins (C3a and C5a) in Non-small Cell Lung Cancer: A Systematic Review - Cureus
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Deficiency of Complement C3a and C5a receptors... : Hypertension - Ovid
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Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity - JCI.org
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Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking - Nature
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Complement C3 and Activated Fragment C3a Are Involved in Complement Activation and Anti-Bacterial Immunity - Frontiers
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The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization - PNAS
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The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure - Nature
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Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage - Frontiers
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Drusen complement components C3a and C5a promote choroidal neovascularization - PNAS
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Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a - Nature
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Complement and inflammasome crosstalk in chronic inflammation - Frontiers
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Brief report on the relation between complement C3a and anti dsDNA antibody in systemic lupus erythematosus - Nature
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Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration - Nature
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A previously unrecognized role of C3a in proteinuric progressive nephropathy - Nature
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Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage - Nature
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Complement activation products in tears of dry eye and meibomian gland dysfunction - Nature
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C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway - Nature
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Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging - Nature
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The inside story on complement activation - Nature
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Activation of C3a receptor is required in cigarette smoke-mediated emphysema - Nature
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Complement‐mediated immune mechanisms in allergy - Laumonnier - 2023 - European Journal of Immunology - Wiley Online Library
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Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease - jneurosci.org
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Pro‐ and Anti‐Inflammatory Role of Complement in Cancer - Pal - 2025 - European Journal of Immunology - Wiley Online Library
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Complement C3a and C5a Receptors Are Presented in Mouse Sciatic and Human Sural Nerves and Selectively Modulate the Neuronal Function of Large-Caliber Fibers in Mice - Wiley Online Library
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In MS, more severe disability is linked with complement protein activation - Multiple Sclerosis News Today
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Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice - American Heart Association Journals
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Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices - Frontiers
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Complement activation and vascular complications after pediatric allogeneic hematopoietic stem cell transplantation - Nature
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Urinary complement biomarkers in immune-mediated kidney diseases - Frontiers
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Visualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis - Huang - 2024 - Muscle & Nerve - Wiley Online Library
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Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics - Frontiers
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Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss - Nature
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Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis - Nature
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Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction - Nature
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Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease - Nature
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Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR | Cell Discovery - Nature
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Urokinase Promotes Redundantly Intratubular C3a-Formation But Not ENaC-Driven Hypertension in DOCA/Salt Kidney Injury - American Heart Association Journals
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Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells - faseb.onlinelibrary.wiley.com
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Increased Complement 3a Receptor is Associated with Behcet’s disease and Vogt-Koyanagi-Harada disease - Nature
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Complement fragments C3a and C5a: The salt and pepper of the immune response - Wiley Online Library
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Activation of the complement system generates antibacterial peptides - PNAS
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Complements and the Wound Healing Cascade: An Updated Review - Sinno - 2013 - Plastic Surgery International - Wiley Online Library
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Complement Activation during Cardiopulmonary Bypass | NEJM - The New England Journal of Medicine
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The relationship between serum CTRP-5, C3a/desArg, and complement-C3 levels and hypothyroidism in women with polycystic ovary syndrome - springermedicine.com
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Complement: a novel factor in basal and ischemia‐induced neurogenesis - Springer Nature Link
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SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling - Nature
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Novel drug candidates offer new route to controlling inflammation - EurekAlert!
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Small Particles in AAV Patients May Serve as Blood Biomarker of Kidney Problems, Study Suggests - ANCA Vasculitis News
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.