Why is "C-Raf" trending?

Search Interest Perspective

• Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells - Nature
• A homesick mechanic stole a C-130 to fly home to his wife - Boing Boing
• 1,100 Miles Into The Arctic: RAF C-17 Globemaster Lands At Earth's Most Northerly Base - Simple Flying
• Depolarization-Dependent C-Raf Signaling Promotes Hyperexcitability and Reduces Opioid Sensitivity of Isolated Nociceptors after Spinal Cord Injury - Journal of Neuroscience
• Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism - pnas.org
• Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC - Nature
• Working together: Royal Navy Wildcats delivered to Akrotiri thanks to the RAF - Forces News
• Cell Type–Specific Importance of Ras–c-Raf Complex Association Rate Constants for MAPK Signaling - Science | AAAS
• World War Two RAF plane to fly over Buckinghamshire village fete next week - bucksfreepress.co.uk
• Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation - Nature
• PDE8A runs interference to limit PKA inhibition of Raf-1 - pnas.org
• Targeting the Raf kinases in human cancer: the Raf dimer dilemma - Nature
• TM7SF2 regulates cell proliferation and apoptosis by activation of C-Raf/ERK pathway in cervical cancer - Nature
• KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation - Nature
• Cryo-EM structure of a RAS/RAF recruitment complex - Nature
• Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase - Nature
• X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility - Nature
• The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade - Nature
• IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells - Nature
• A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1 - Nature
• Essential role of B-Raf in ERK activation during extraembryonic development - pnas.org
• RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition - Nature
• MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ - pnas.org
• /MPTP-induced neurotoxicity through the C-Raf–ERK1/2-dependent anti-apoptotic pathway - Nature
• RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma - Nature
• Caught in the Act - Harvard Medical School
• ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation - Science | AAAS
• TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1 - Nature
• Shaping Designer Proteins - medschool.duke.edu
• BRAF as therapeutic target in melanoma - ScienceDirect.com
• RAF kinases are stabilized and required for dendritic cell differentiation and function - Nature
• Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF - pnas.org
• The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants - Nature
• First C-130J with new centre wing returns to RAF - Marshall Aerospace and Defence Group
• Interactome dynamics of RAF1-BRAF kinase monomers and dimers - Nature
• Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway - pnas.org
• Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering - Nature
• Raf promotes dimerization of the Ras G-domain with increased allosteric connections - pnas.org
• Hsp90 provides a platform for kinase dephosphorylation by PP5 - Nature
• CRAF R391W is a melanoma driver oncogene - Scientific Reports - Nature
• Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells - Nature
• CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop - Wiley Online Library
• The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop - Science | AAAS
• Quest for Clinically Effective RAF Dimer Inhibitors - ASCO Publications
• Does Ras Activate Raf and PI3K Allosterically? - frontiersin.org
• Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins | Oncogene - Nature
• USP7 regulates the ERK1/2 signaling pathway through deubiquitinating Raf-1 in lung adenocarcinoma - Nature
• CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles - Nature
• Development of Highly Sensitive Biosensors of RAF Dimerization in Cells | Scientific Reports - Nature
• N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence - pnas.org
• RAF Mildenhall serves as base for Turkish C-130 engine replacement - usafe.af.mil
• The Raf Inhibitor Paradox: Unexpected Consequences of Targeted Drugs - ScienceDirect.com
• Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane - pnas.org
• DA-Raf–dependent inhibition of the Ras-ERK signaling pathway in type 2 alveolar epithelial cells controls alveolar formation - pnas.org
• V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors - pnas.org
• Identification of an H-Ras nanocluster disrupting peptide - Nature
• Effect of SB 203580 on the activity of c-Raf in vitro and in vivo - Nature
• Effector Binding Sequentially Alters KRAS Dimerization on the Membrane: New Insights Into RAS-Mediated RAF Activation - Wiley & Sons
• Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors - pnas.org
• The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans - Science | AAAS
• Case report: Successful use of MEK inhibitors as an adjuvant approach in the treatment of pediatric MAP4 RAF1 fusion-positive solid tumor - Nature
• Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop - pnas.org
• RAF deploys additional C-UAS capabilities in the Middle East - Unmanned airspace
• Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf - Nature
• B4 Raf‐like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO‐UBIQUITINATION 2 - Wiley & Sons
• UK RAF C-17s Proving Data Analysis Tools For Boeing Product Support - Aviation Week
• CNIO researchers succeed at removing some types of pancreatic cancer in animal models - cnio.es
• Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase - Nature
• In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction - pnas.org
• The RAF could soon retire the C-130J and replacing it with the A400M – A move that would put SAS sold... - The Aviation Geek Club
• Raf-like kinases and receptor-like (pseudo)kinase GHR1 are required for stomatal vapor pressure difference response - pnas.org
• X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk - Nature
• UK A400M vs. C-130J: Higher Availability Rates than Departing A400 RAF - Airforce Technology
• Progression of RAS-Mutant Leukemia during RAF Inhibitor Treatment - The New England Journal of Medicine
• Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis - Nature
• Cool Video shows RAF C-130 Hercules retirement Flypast Through Mach Loop - The Aviation Geek Club
• Conferring specificity on the ubiquitous Raf/MEK signalling pathway | British Journal of Cancer - Nature
• The MAPK signalling pathways and colorectal cancer - The Lancet
• Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 - Nature
• RAF C-17 Trained For The First Time To Operate From Austere Runways - theaviationist.com
• RAF Georgia: ‘Merab Vs. Cejudo’ Live Results, Highlights - MMA Mania
• Cool Video features RAF C-130 Hercules Cargo Aircraft performing Beach Landings - The Aviation Geek Club
• RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα - Science | AAAS
• Overexpressed Raf-1 and phosphorylated cyclic adenosine 3′-5′-monophosphatate response element-binding protein are early markers for lung adenocarcinoma - acsjournals.onlinelibrary.wiley.com
• RAF "Pinky" Jaguar has been "rebranded" to celebrate the 75th anniversary of 238 Sqn deployment to North Africa - theaviationist.com
• UK ends operations with Hercules, Argentina receives another aging C-130H - Air Data News
• RAF C-17 Globemaster delivers more vital aid to support civilians in Gaza - Royal Air Force
• V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway - pnas.org
• Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis - Science | AAAS
• 7th C-17 For RAF Arrives In UK - Aero-News.net
• UK axes another C-130J, leaving just a handful in RAF service - Key Aero
• No, Germany Did Not Deny RAF C-17s Bound For Ukraine Access to Its Airspace - theaviationist.com
• Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf - Nature
• Control of B cell development by Ras‐mediated activation of Raf - The EMBO Journal - Springer Nature Link
• ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers - Nature
• Türkiye prepares for twelve C-130J Hercules aircraft delivery from UK: Report - Türkiye Today
• RAF aeromedical evacuation specialists train to survive -20°C arctic temperatures - Forces News
• A white mouse … - Salle de presse de l'Inserm
• RAF Regiment Continues to Deliver Effective Counter‑Drone Defence Across the Middle East - Royal Air Force
• New £2.6M maintenance contract for RAF C-17 fleet - Royal Air Force