Why is "Birt-Hogg-Dube syndrome" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-28 22:38:16
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Birt-Hogg-Dube_syndrome entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-28 and was most recently seen on 2026-05-28.
Wikipedia Overview
Birt–Hogg–Dubé syndrome (BHD), also Hornstein–Birt–Hogg–Dubé syndrome, Hornstein–Knickenberg syndrome, and fibrofolliculomas with trichodiscomas and acrochordons is a human, adult onset, autosomal dominant genetic disorder caused by a mutation in the folliculin (FLCN) gene. It can cause susceptibility to kidney cancer, renal and pulmonary cysts, and noncancerous tumors of the hair follicles, called fibrofolliculomas. The symptoms seen in each family are unique, and can include any combination of the three symptoms. Fibrofolliculomas are the most common manifestation, found on the face and upper trunk in over 80% of people with BHD over the age of 40. Pulmonary cysts are equally common (84%) and 24% of people with BHD eventually experience a collapsed lung. Kidney tumors, both cancerous and benign, occur in 14–34% of people with BHD; the associated kidney cancers are often rare hybrid tumors.
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Trending Topic Today
Search Interest Perspective
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Genotype-based prevalence of Birt-Hogg-Dubé syndrome in the healthcare and genomic registry populations – breaking the ‘rare disease’ status? - Nature
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Birt-Hogg-Dubé syndrome: A case report | Medicina Clínica (English Edition) - www.elsevier.com
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Risk of malignant melanoma and colorectal cancer in Birt-Hogg-Dubé syndrome – a matched cohort study - Nature
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Multiple Skin Adnexal Tumours with Possible Syndromic Association - Cureus
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Birt–Hogg–Dubé syndrome: Clinical and genetic characterization - www.elsevier.com
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Risk of pneumothorax in Birt-Hogg-Dubé syndrome during pregnancy and birth - Frontiers
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Birt-Hogg-Dubé syndrome: diagnosis and management - The Lancet
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Inherited predisposition to pneumothorax: estimating the frequency of Birt-Hogg-Dubé syndrome from genomics and population cohorts - thorax.bmj.com
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Respirology Case Reports | APSR Respiratory Medicine Journal - Wiley Online Library
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Birt-Hogg-Dubé Syndrome - RSNA Journals
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One in 3,000 people at risk of punctured lung from faulty gene – almost 100 times higher than previous estimate - University of Cambridge
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Spontaneous Pneumothorax Diagnosed As Birt-Hogg-Dubé Syndrome: A Report of a Rare Case - Cureus
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Oncocytic Thyroid Tumours With Pathogenic FLCN Mutations Mimic Oncocytic Papillary Thyroid Carcinoma on Fine-Needle Aspiration - Wiley Online Library
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Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome cell models through transcriptomic and proteomic analysis | Oncogene - Nature
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Tailored Anesthetic Management in a Patient With Birt-Hogg-Dubé Syndrome: Navigating the Risk of Pneumothorax and Renal Dysfunction in a Case Report - Cureus
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A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome - Nature
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Parotid Acinic Cell Carcinoma as a Presentation of Birt-Hogg-Dube Syndrome - Cureus
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Hydropneumothorax as a Presentation of Birt-Hogg-Dubé Syndrome - Cureus
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Renal cancer and pneumothorax risk in Birt–Hogg–Dubé syndrome; an analysis of 115 FLCN mutation carriers from 35 BHD families - Nature
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Renal and Lung Cysts in Birt-Hogg-Dubé Syndrome: A Continuum of the Same Disorder - Cureus
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Pericardial Cyst in Birt-Hogg-Dubé Syndrome: An Unexpected Discovery - Cureus
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Joan Brunet: Raising awareness about Birt-Hogg-Dubé Syndrome - Oncodaily
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Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt–Hogg–Dubé syndrome - Nature
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Novel germline mutations in FLCN gene identified in two Chinese patients with Birt–Hogg–Dubé syndrome - Springer Nature Link
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Folliculin depletion results in liver cell damage and cholangiocarcinoma through MiT/TFE activation - Nature
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Differential mTORC1 pathways in BHD - Nature
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Topical Rapamycin as a Treatment for Fibrofolliculomas in Birt-Hogg-Dubé Syndrome: A Double-Blind Placebo-Controlled Randomized Split-Face Trial - PLOS
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Unknown COL5A1 mutation found in man with classical EDS symptoms |... - Ehlers-Danlos News
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Concurrent Germline and Somatic Mutations in FLCN and Preliminary Exploration of Its Function: A Case Report - Frontiers
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Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11.2 - Nature
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FIGURE 3 - ERS - European Respiratory Society
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Renal Cell Tumor and Cystic Lung Disease: A Genetic Link for Generalists to Be Aware of - Cureus
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Cystic Lung Disease Presenting as Recurrent Non-traumatic Chylothorax: Case Report and a Mini-Review - Cureus
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PRDM10 RCC: A Syndrome Resembling BHD with Aggressive Renal Tumors Mimicking Type 2 Papillary RCC - Physician's Weekly
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The Hidden Gene That Can Collapse Your Lung – And It’s 100x More Common Than We Thought - SciTechDaily
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Quantitative Analysis of Cystic Lung Diseases by Use of Paired Inspiratory and Expiratory CT: Estimation of the Extent of Cyst-Airway Communication and Evaluation of Diagnostic UtilityRadiology: Cardiothoracic Imaging - RSNA Journals
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Genetic screening of the FLCN gene identify six novel variants and a Danish founder mutation - Nature
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A Puzzling Pneumothorax in a 36-Year-Old Woman - Medscape
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Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways - Frontiers
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A Solitary Fibrofolliculoma in Close Proximity to the Medial Canthus - Cureus
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Study of genetic condition leads to discovery of mechanism that promotes cance development - Ricerca Malattie Genetiche Rare
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Distinguishing the histological and radiological features of cystic lung disease in Birt–Hogg–Dubé syndrome from those of tobacco-related spontaneous pneumothorax - Wiley Online Library
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An Unusual Case of Severe Cystic Lung Disease: A Case Report and Review of the Literature - Cureus
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Autosomal dominant genodermatoses in adults being heralded by superimposed skin lesions in children - Wiley Online Library
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Recurrent pneumothorax - The Lancet
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Linda Evangelista admits she’s ‘not interested’ in dating - NZ Herald
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What is Chromophobe Renal Cell Carcinoma? - Cancer Therapy Advisor
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Genetics can influence kidney cancer risk - The New Indian Express
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Hereditary kidney cancer - Wiley & Sons
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Multiple Facial Papules - MDEdge
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Mother with rare condition thanks Ysbyty Gwynedd team who helped safely deliver her healthy baby girl - Betsi Cadwaladr University Health Board
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.