Why is "Beta-sheet" trending?

Search Interest Perspective

• Reversibility and β-sheet formation are decoupled in tau condensate aging - PNAS
• β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling - Nature
• Dissecting the Molecular Determinants of α-synuclein Phase Separation and Condensate Aging: The Pivotal Role of β-Sheet-Rich Motifs - Wiley
• Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates - Nature
• Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM - Science | AAAS
• Parametrically guided design of beta barrels and transmembrane nanopores using deep learning - PNAS
• Five new rippled beta-sheets are elucidated by chemists employing peptides from Alzheimer’s and Type II diabetes - UCLA – Chemistry and Biochemistry
• pH-triggered clustering regulates β -sheet activation in silk assembly - Nature
• Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross- β -sheet formation - Nature
• Arg–Tyr cation–π interactions drive phase separation and β-sheet assembly in native spider dragline silk - PNAS
• In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy - Nature
• The discovery of the α-helix and β-sheet, the principal structural features of proteins - PNAS
• Crosslinking, salt-induced aging, and secondary structure formation in Peptide-containing coacervates inspired by spider silk | Communications Chemistry - Nature
• Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation - PNAS
• A solid beta-sheet structure is formed at the surface of FUS droplets during aging - Nature
• Intrinsic β-sheet propensities result from van der Waals interactions between side chains and the local backbone - PNAS
• A bioinformatics approach to design minimal biomimetic metal-binding peptides | Communications Chemistry - Nature
• Locating folds of the in-register parallel β-sheet of the Sup35p prion domain infectious amyloid - PNAS
• Transferrin receptor targeting by de novo sheet extension - PNAS
• Many dissimilar NusG protein domains switch between α-helix and β-sheet folds - Nature
• De novo design of a non-local β-sheet protein with high stability and accuracy - Nature
• Evidence for Intramolecular Antiparallel Beta-Sheet Structure in Alpha-Synuclein Fibrils from a Combination of Two-Dimensional Infrared Spectroscopy and Atomic Force Microscopy - Nature
• Antiparallel β‐Sheet as a Key Motif of Amyloid‐β Inhibitor Designed via Topological Peptide Reprogramming - Wiley Online Library
• Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly - Nature
• Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site - Nature
• Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species - Nature
• Rational combinatorial design of pore-forming β-sheet peptides - PNAS
• Beating the Heat - Fast Scanning Melts Silk Beta Sheet Crystals - Nature
• Length-dependent stability and strand length limits in antiparallel β-sheet secondary structure - PNAS
• Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases - Nature
• Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates - PNAS
• Exposing the distinctive modular behavior of β-strands and α-helices in folded proteins - PNAS
• De novo design of peptides that coassemble into β sheet–based nanofibrils - Science | AAAS
• Uncovering the Networks of Topological Neighborhoods in β-Strand and Amyloid β-Sheet Structures - Nature
• Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity - Nature
• New study confirms 'rippled sheet' protein structure predicted in 1953 - Phys.org
• Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling - Wiley Online Library
• The hot sites of α-synuclein in amyloid fibril formation - Nature
• Amyloid beta: structure, biology and structure-based therapeutic development | Acta Pharmacologica Sinica - Nature
• Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils - PNAS
• β-barrel Oligomers as Common Intermediates of Peptides Self-Assembling into Cross-β Aggregates - Nature
• Correlated motions are a fundamental property of β-sheets - Nature
• BetaDL: A protein beta-sheet predictor utilizing a deep learning model and independent set solution - ScienceDirect.com
• Carbonization of a stable β-sheet-rich silk protein into a pseudographitic pyroprotein - Nature
• Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register β-sheet structure - PNAS
• Role of Sheet-Edge Interactions in β-sheet Self-Assembling Peptide Hydrogels - ACS Publications
• An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies - Nature
• Fundamental protein structure engineered in lab - UW Medicine | Newsroom
• Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL - PNAS
• Paired β-sheet structure of an Aβ(1-40) amyloid fibril revealed by electron microscopy - PNAS
• Competition between β-Sheet and Coacervate Domains Yields Diverse Morphologies in Mixtures of Oppositely Charged Homochiral Polypeptides - ACS Publications
• Chemists use peptides from Alzheimer’s and Type II diabetes to describe five new rippled beta-sheets - UC Santa Cruz - News
• pH-Controlled Reversible Folding of Copolymers via Formation of β-sheet Secondary Structures - Wiley Online Library
• Single-molecule visualization determines conformational substate ensembles in β-sheet–rich peptide fibrils - Science | AAAS
• Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation - PNAS
• Protein chemical shifts arising from α-helices and β-sheets depend on solvent exposure - PNAS
• Polysaccharide hydrogels with tunable stiffness and provasculogenic properties via α-helix to β-sheet switch in secondary structure - PNAS
• In situ atomic force microscopy study of Alzheimer’s β-amyloid peptide on different substrates: New insights into mechanism of β-sheet formation - PNAS
• Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril - PNAS
• Conformational transition of amyloid β-peptide - PNAS
• Mirror-image peptides form 'rippled sheet' structure predicted in 1953 - Phys.org
• An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated β-sheet structure for amyloid - PNAS
• β‐sheets mediate the conformational change and allosteric signal transmission between the AsLOV2 termini - Wiley Online Library
• Exploration of novel αβ-protein folds through de novo design - Nature
• Role of backbone strain in de novo design of complex α/β protein structures - Nature
• Inter-molecular β-sheet structure facilitates lung-targeting siRNA delivery - Nature
• pH-controlled stacking direction of the β-strands in peptide fibrils - Nature
• Extended β-Strands Contribute to Reversible Amyloid Formation - ACS Publications
• Stoichiometry-controlled secondary structure transition of amyloid-derived supramolecular dipeptide co-assemblies - Nature
• Nanoconfinement controls stiffness, strength and mechanical toughness of β-sheet crystals in silk - Nature
• Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets - Nature
• The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism - PNAS
• HyperBeta: characterizing the structural dynamics of proteins and self-assembling peptides - Nature
• Coherent Raman microscopy visualizes ongoing cellular senescence through amide I peak shifts originating from β sheets in disordered nucleolar proteins - Nature
• Conformation and dynamics of soluble repetitive domain elucidates the initial β-sheet formation of spider silk - Nature
• Expanding heme-protein folding space using designed multi-heme β-sheet mini-proteins - Nature
• Structural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein - Nature
• Extension of the classical classification of β-turns - Nature
• Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability - PNAS
• Molecular basis for amyloid-β polymorphism - PNAS
• How Colorful Ribbon Diagrams Became the Face of Proteins - Quanta Magazine
• WashU researchers shine light on amyloid architecture - WashU
• Folding mechanism of the metastable serpin α1-antitrypsin - PNAS
• Conserved leucine-rich repeat proteins in the adhesive projectile slime of velvet worms - PNAS
• Structural motif of polyglutamine amyloid fibrils discerned with mixed-isotope infrared spectroscopy - PNAS
• Characterizing tau aggregates in neurodegenerative diseases - MIT News
• Enzyme Digests Amyloid-Beta Associated with Alzheimer’s Disease - WCM Newsroom
• Comparative Analysis of TM and Cytoplasmic β-barrel Conformations Using Joint Descriptor - Nature
• Transmission of light signals from the light-oxygen-voltage core via the hydrophobic region of the β-sheet surface in aureochrome-1 | Scientific Reports - Nature
• A self-assembled protein β-helix as a self-contained biofunctional motif - Nature
• Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue - Nature
• The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils - Nature
• Aromatic Stacking Facilitated Self-Assembly of Ultrashort Ionic Complementary Peptide Sequence: β-Sheet Nanofibers with Remarkable Gelation and Interfacial Properties - ACS Publications
• Protein secondary structure in spider silk nanofibrils - Nature
• Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from β-Sheet to α-Helix - Wiley Online Library
• Combinatorial approaches: A new tool to search for highly structured β-hairpin peptides - PNAS
• Matching amino acids membrane preference profile to improve activity of antimicrobial peptides - Nature
• Probing the Interplay of Protein Self‐Assembly and Covalent Bond Formation in Photo‐Crosslinked Silk Fibroin Hydrogels - Tran - 2025 - Small - Wiley Online Library
• E22G Aβ40 fibril structure and kinetics illuminate how Aβ40 rather than Aβ42 triggers familial Alzheimer’s - Nature
• A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein - Nature