Why is "Bcl-xL" trending?

Search Interest Perspective

• Dual targeting of BCL-XL and MCL-1 exposes a rapid and exploitable apoptotic vulnerability in non-small cell lung cancer - Nature
• Genotoxic antibody-drug conjugates combined with BCL-XL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer - JCI.org
• Structural and dynamic basis of indirect apoptosis inhibition by Bcl-xL: A case study with Bid - PNAS
• SADS-CoV NS3 induces apoptosis by blocking the formation of Bcl-xL-BAK complex - ASM Journals
• Clearance of Senescent Cells by BCLXL‐PROTAC: A Novel Approach to Treat COPD? - Devulder - 2026 - Aging Cell - Wiley Online Library
• Mechanistic overview and suggested strategies to overcome BCL-2 inhibitor resistance in TP53-mutated acute myeloid leukemia - frontiersin.org
• Functional profiling of ovarian cancer models reveals Bcl-xL/NOTCH targeting to overcome resistance - Nature
• Study reveals how Bcl-2 protein blocks cancer cell death - News-Medical
• Targeting protein BCL-2 may create a promising pathway to reversing pulmonary fibrosis - Medical Xpress
• Sonrotoclax and Next-Generation BCL-2 Inhibitors for Treating CLL - OncLive
• BeOne's Venclexta challenger Beqalzi nets FDA approval as first BCL-2 for mantle cell lymphoma - Fierce Pharma
• and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53 -deficient mice - Nature
• Anti-apoptotic BCL-2 family proteins: from regulatory networks to therapeutic targeting - Nature
• A2-pancortins interact with Bcl-xL and WAVE1 to promote mitochondria-ER contact sites (MERCs) and exacerbate mitochondrial calcium elevation to mediate cell death in stroke | Scientific Reports - Nature
• Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity - Nature
• Platelet aging and desialylation increase apoptotic priming and BCL-XL dependence | Cell Death & Disease - Nature
• What does BCL-2 do? From new molecular insights to the clinical implications | Cell Death & Differentiation - Nature
• Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism - Nature
• Beqalzi: FDA Approves New Oral BCL-2 Blocker for Relapsed or Refractory Mantle Cell Lymphoma - WebMD
• BCL-2 Inhibitors Market Poised for Robust Growth During the Forecast Period (2025-2034) as Oncology Pipelines Expand | DelveInsight - PR Newswire
• Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma - elsevier.es
• BCL-XL–targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors - Science | AAAS
• BCL‐2 inhibition in Waldenström macroglobulinaemia and marginal zone lymphoma - Wiley Online Library
• Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer - Nature
• The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release - Nature
• BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation - Nature
• BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells - Nature
• BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress - Nature
• inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAF - Nature
• Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy - Nature
• The BCL-2 protein family: from discovery to drug development - Cell Death & Differentiation - Nature
• Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells - Nature
• Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL - Nature
• A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice - Nature
• BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival - Nature
• BCL-2 family proteins: changing partners in the dance towards death | Cell Death & Differentiation - Nature
• Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL - Nature
• Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis - Nature
• BCL-xL dependency in chromophobe renal cell carcinoma - Cancer Gene Therapy - Nature
• Bcl-xL promotes metastasis independent of its anti-apoptotic activity - Nature
• cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities - Nature
• Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity - Nature
• Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice - Nature
• Bcl-xL controls a switch between cell death modes during mitotic arrest - Nature
• Computational design of BclxL inhibitors that target transmembrane domain interactions - PNAS
• BCL-XL is an actionable target for treatment of malignant pleural mesothelioma | Cell Death Discovery - Nature
• Bcl-xL activity influences outcome of the mitotic arrest - frontiersin.org
• BCL-XL directly modulates RAS signalling to favour cancer cell stemness - Nature
• Bcl-2 family inhibitors sensitize human cancer models to therapy - Nature
• Cryptic-site binding mechanism of medium-sized Bcl-xL inhibiting compounds elucidated by McMD-based dynamic docking simulations - Nature
• Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol - Nature
• Structure-guided design of a selective BCL-X - Nature
• MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies - Nature
• A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma - Nature
• Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport - Nature
• Bcl-xL is an oncogenic driver in colorectal cancer - Cell Death & Disease - Nature
• Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B - Nature
• BCL-2 family isoforms in apoptosis and cancer - Nature
• Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis - Nature
• Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak - Nature
• The BCL-2 protein family: opposing activities that mediate cell death - Nature
• BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis | Cell Death Discovery - Nature
• Suppressing BCL-XL increased the high dose androgens therapeutic effect to better induce the Enzalutamide-resistant prostate cancer autophagic cell death - Nature
• Why do BCL-2 inhibitors work and where should we use them in the clinic? - Nature
• The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria | Cell Death & Differentiation - Nature
• Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations - Nature
• Bcl-xL inhibition enhances Dinaciclib-induced cell death in soft-tissue sarcomas | Scientific Reports - Nature
• ’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance - Nature
• The BCL-2 arbiters of apoptosis and their growing role as cancer targets - Nature
• Synergistic interaction between HDAC and MCL-1 inhibitors through downregulation of BCL-XL in multiple myeloma - Haematologica
• The secrets of the Bcl-2 family - Cell Death & Differentiation - Nature
• Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis - Nature
• MOMP, cell suicide as a BCL-2 family business - Cell Death & Differentiation - Nature
• Anti-apoptotic BCL-2 family members in development - Cell Death & Differentiation - Nature
• Inhibition of the Bcl-xL Deamidation Pathway in Myeloproliferative Disorders - NEJM
• Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation - Nature
• Anti-apoptotic BCL-2 family proteins in acute neural injury - frontiersin.org
• Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing - frontiersin.org
• Addition of BCL-XL/BCL-2 Inhibitor Navitoclax to Ongoing Ruxolitinib in Patients With Myelofibrosis With Disease Progression or Suboptimal Response - The ASCO Post
• Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells - Science | AAAS
• Inhibition of anti-apoptotic Bcl-2 family members promotes synergistic cell death with ER stress inducers by disrupting autophagy in glioblastoma - Nature
• –Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis - Nature
• : implications for selectivity of antagonists of the Bcl-2 family - Nature
• BCL-2 inhibitors in hematological malignancies: biomarkers that predict response and management strategies - frontiersin.org
• regulates metabolic efficiency of neurons through interaction with the mitochondrial F - Nature
• How the Bcl-2 family of proteins interact to regulate apoptosis - Nature
• Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential - Rockefeller University Press
• Pulling the plug on BCL-X - Nature
• Evaluating the inhibitory priority of Bcl‐xL to Bad, tBid and Bax by using live‐cell imaging assay - Wiley Online Library
• Expression profile of Bcl‐2 family proteins in newly diagnosed multiple myeloma patients - Wiley Online Library
• Mcl-1 and Bcl-xL are essential for survival of the developing nervous system - Nature
• Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death - Nature
• Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins - frontiersin.org
• Anti-apoptotic BCL-2 regulation by changes in dynamics of its long unstructured loop - Nature
• BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death - PNAS
• and Bcl-2 enhances the angiogenic phenotype of endothelial cells - Nature
• Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma - Nature
• Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation - frontiersin.org
• Bcl-2 on the brink of breakthroughs in cancer treatment - Cell Death & Differentiation - Nature
• The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway - Nature