Why is "Base pair" trending?
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- Date: 2026-03-18 03:45:46
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Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix and contribute to the folded structure of both DNA and RNA. Dictated by specific hydrogen bonding patterns, "Watson–Crick" base pairs allow the DNA helix to maintain a regular helical structure that is subtly dependent on its nucleotide sequence. The complementary nature of this based-paired structure provides a redundant copy of the genetic information encoded within each strand of DNA. The regular structure and data redundancy provided by the DNA double helix make DNA well suited to the storage of genetic information, while base-pairing between DNA and incoming nucleotides provides the mechanism through which DNA polymerase replicates DNA and RNA polymerase transcribes DNA into RNA. Many DNA-binding proteins can recognize specific base-pairing patterns that identify particular regulatory regions of genes.
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Search Interest Perspective
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An unnatural base pair for the detection of epigenetic cytosine modifications in DNA - Nature
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Nucleic acid base pair open states by hydrogen exchange - PNAS
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Expands the genetic alphabet: Artificial DNA base pair uses halogen bonds to form stable structures - Phys.org
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Human genome structure mapped at base-pair resolution - Progress Educational Trust
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Acid-base pair-mediated copolymerization of acid-sensitive epoxides and cyclic anhydride for synthesizing recyclable thermoplastics - Nature
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Scientists map DNA folding at single base-pair resolution in living cells - Phys.org
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Streamline mNGS analysis with Micronbrane Medical and Basepair on AWS | Amazon Web Services - Amazon Web Services
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Deep generalizable prediction of RNA secondary structure via base pair motif energy - Nature
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Democratize Omics Data Analysis with Basepair on AWS HealthOmics - Amazon Web Services
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Shedding light on the base-pair opening dynamics of nucleic acids in living human cells - Nature
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A base-pair view of interactions between genes and their enhancers - Nature
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Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA - Nature
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Joint disease-specificity at the regulatory base-pair level - Nature
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A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription - Nature
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Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA - Nature
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From base pair to brain - Nature
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A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT - Nature
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Publisher Correction: Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA | Communications Biology - Nature
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Metal-mediated DNA strand displacement and molecular device operations based on base-pair switching of 5-hydroxyuracil nucleobases - Nature
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Crystallographic evidence of Watson–Crick connectivity in the base pair of anionic adenine with thymine - PNAS
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DNA calorimetric force spectroscopy at single base pair resolution - Nature
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The base pair-scale diffusion of nucleosomes modulates binding of transcription factors - PNAS
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Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides - Nature
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Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution - Nature
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Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase - Nature
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Asymmetric base-pair opening drives helicase unwinding dynamics - PNAS
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Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding - PNAS
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Enhancement of RecA-mediated self-assembly in DNA nanostructures through basepair mismatches and single-strand nicks - Nature
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A map of nucleosome positions in yeast at base-pair resolution - Nature
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Basepair | AWS | Case Study - Amazon Web Services
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Genetic alphabet expansion biotechnology by creating unnatural base pairs - ScienceDirect.com
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Novel 199 base pair NEFH promoter drives expression in retinal ganglion cells - Nature
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Base-pair quality check - Nature
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HideRNAs protect against CRISPR-Cas9 re-cutting after successful single base-pair gene editing - Nature
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Identification of DNA lesions using a third base pair for amplification and nanopore sequencing - Nature
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Computational and NMR studies of RNA duplexes with an internal pseudouridine-adenosine base pair - Nature
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Single-molecule measurements of synthesis by DNA polymerase with base-pair resolution - PNAS
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Epigenome characterization at single base-pair resolution - PNAS
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RNA expression analysis using a 30 base pair resolution Escherichia coli genome array - Nature
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Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus - Nature
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Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch - Nature
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Analysis of the effect of base-pair mismatch on DNA melting temperatures through UV-visible absorption spectroscopy - Select Science
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A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria - PNAS
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Direct observation of base-pair stepping by RNA polymerase - Nature
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A critical base pair in k-turns that confers folding characteristics and correlates with biological function - Nature
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Protein−DNA binding in the absence of specific base-pair recognition - PNAS
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Contribution of the Closing Base Pair to Exceptional Stability in RNA Tetraloops: Roles for Molecular Mimicry and Electrostatic Factors - ACS Publications
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Labeling Chemistry Improves Structural Variant Detection Resolution Down to 500 Base Pair - Inside Precision Medicine
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From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine - Wiley Interdisciplinary Reviews
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Increased leukotoxin production: Characterization of 100 base pairs within the 530 base pair leukotoxin promoter region of Aggregatibacter actinomycetemcomitans - Nature
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Tailored Tolane-Perfluorotolane Assembly as Supramolecular Base Pair Replacement in DNA - Wiley Online Library
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TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning - Nature
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A single base pair duplication in the SLC33A1 gene is associated with fetal losses and neonatal lethality in Manech Tête Rousse dairy sheep - Ben Braiek - 2024 - Animal Genetics - Wiley Online Library
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Subtle Recognition of 14-Base Pair DNA Sequences via Threading Polyintercalation - ACS Publications
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Efficient Deactivation of a Model Base Pair via Excited-State Hydrogen Transfer - Science | AAAS
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Simulations of RNA base pairs in a nanodroplet reveal solvation-dependent stability - PNAS
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The photophysics of protonated cytidine and hemiprotonated cytidine base pair: A computational study - Wiley Online Library
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CREST maps somatic structural variation in cancer genomes with base-pair resolution - Nature
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A Thiazole Coumarin (TC) Turn-On Fluorescence Probe for AT-Base Pair Detection and Multipurpose Applications in Different Biological Systems - Nature
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A DNA methylation map of human cancer at single base-pair resolution - Nature
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An unnatural base pair for incorporating amino acid analogs into proteins - Nature
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Scripps Research Institute Achieves Milestone with First Artificial DNA Base Pairs - California Council on Science and Technology (CCST)
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Artificial DNA Base Pair Used as Amplifiable Marker of Genomic Damage - Genetic Engineering and Biotechnology News
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Biochemical evidence for the requirement of Hoogsteen base pairing for replication by human DNA polymerase ι - PNAS
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Determination of Base Binding Strength and Base Stacking Interaction of DNA Duplex Using Atomic Force Microscope - Nature
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Distinct domains of tRNA synthetase recognize the same base pair - Nature
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Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution - Nature
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Structure of a purine-purine wobble base pair in the decoding center of the ribosome - Nature
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Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states - Nature
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Non-Standard Bonding in Base Pairs - NASA Astrobiology (.gov)
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Enzymes Can’t Tell Artificial DNA From the Real Thing - UC San Diego Today
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Backtracking by single RNA polymerase molecules observed at near-base-pair resolution - Nature
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Ginkgo Bioworks and Twist Bioscience Just Made a 100 Million Base Pair Deal - SynBioBeta
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THEORETICAL STUDY OF THE NON-WATSON-CRICK BASE PAIR GUANINE-GUANINE - SciELO Chile
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Hoogsteen base pair formation promotes synthesis opposite the 1, N - Nature
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Measuring forces in the DNA molecule - EurekAlert!
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Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter - Nature
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Transcription Factors May Inadvertently Lock in DNA Mistakes - Duke Today
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A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase - Nature
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DNA-dependent divalent cation binding in the nucleosome core particle - PNAS
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Rapid ribosomal translocation depends on the conserved 18-55 base pair in P-site transfer RNA - Nature
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Bacterium survives unnatural DNA transplant - Chemistry World
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Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair - Nature
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Widespread transient Hoogsteen base pairs in canonical duplex DNA with variable energetics - Nature
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SuperSAGE array: the direct use of 26-base-pair transcript tags in oligonucleotide arrays - Nature
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Atomistic understanding of the C·T mismatched DNA base pair tautomerization via the DPT: QM and QTAIM computational approaches - Wiley Online Library
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Scientists built an 8 base pair DNA double helix with potential to create new lifeforms - fanaticalfuturist.com
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Quantifying the impact of simple DNA parameters on the cyclization J -factor for single-basepair-addition families - Nature
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New Organisms Have Been Formed Using The First Ever 6-Letter Genetic Code - ScienceAlert
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PRIMA: a rapid and cost-effective genotyping method to detect single-nucleotide differences using probe-induced heteroduplexes - Nature
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Hoogsteen base pair interactions during mutagenic bypass of benzopyrene dG adducts – Spratt Lab - Sites at Penn State
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Density functional theory studies on cytosine analogues for inducing double-proton transfer with guanine - Nature
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Replication infidelity via a mismatch with Watson–Crick geometry - PNAS
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Synthesis of DNA Oligomers Possessing a Covalently Cross-Linked Watson–Crick Base Pair Model - Wiley Online Library
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Study reveals how the most common DNA mutation happens - Ohio State News
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Laboratory evolution of Geobacter sulfurreducens for enhanced growth on lactate via a single-base-pair substitution in a transcriptional regulator - Nature
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‘Alien’ DNA makes proteins in living cells for the first time - Nature
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At Long Last, Artificial DNA Base Pairs Are Proven Capable of ‘Replication’ - rcast.u-tokyo.ac.jp
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A DNA-centered explanation of the DNA polymerase translocation mechanism - Nature
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On the absence of intrahelical DNA dynamics on the μs to ms timescale - Nature
Why This Topic Is Trending
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.