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This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
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Autonomously_replicating_sequence entered the ranking for the first time today at position #. This is its highest position ever recorded.
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-27 and was most recently seen on 2026-05-27.
An autonomously replicating sequence contains the origin of replication in the yeast genome. The ARS of S. cerevisiae is a minimal 125 bp, and contains four regions, named in order of their effect on plasmid stability. The A-Domain is highly conserved, any mutation abolishes origin function. Mutations on B1, B2, and B3 will diminish, but not prevent functioning of the origin.
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