Why is "Asparagine" trending?

Search Interest Perspective

• A role for the poly-asparagine repeat in the Plasmodium histone acetyltransferase, PfGCN5 - Nature
• Investigating diet to control asparagine uptake as an adjunct to asparaginase treatment - Frontiers
• Disruption of Asparagine Synthetase Is Associated to Increased Biomass in Lotus japonicus - Wiley Online Library
• Low-Asparagine Wheat Gains U.K. Precision-Bred Status - SeedWorld
• Reshaping the gut microbiome or diet with asparagine may limit cancer growth - Nutrition Insight
• Ultra-low asparagine wheat developed using precision gene editing - Phys.org
• Gut Microbes Shape Cancer Growth and Immunity Through Asparagine Metabolism - Genetic Engineering and Biotechnology News
• Asparagine as a signal for glutamine sufficiency via asparagine synthetase: a fresh evidence-based framework in physiology and oncology - American Physiological Society Journal
• Targeting ATF3-mediated asparagine biosynthesis reverses acquired resistance to KRASG12C inhibitors | Oncogene - Nature
• Asparagine endopeptidase prompts breast cancer–related pericardial calcification by regulating IGF2 and integrin αvβ5 - PNAS
• CRISPR-Edited Wheat Leads to Reduced Acrylamide Without Yield Loss - Food Safety Magazine
• Scientists Develop Ultra-Low Asparagine Wheat Using Precision Breeding to Improve Food Safety - isaaa.org
• A hidden food fight in the gut may shape cancer immunity, scientists found the switch - Earth.com
• Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase - Nature
• METTL1-mediated m7G modification of ASNS mRNA regulates asparagine metabolism reprogramming to promote hepatocellular carcinoma progression | Oncogene - Nature
• A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer - Nature
• Galectin-9 activates microglial asparagine endopeptidase and promotes α-synuclein pathology in Parkinson’s disease - Nature
• Targeting asparagine and cysteine in SARS-CoV-2 variants and human pro-inflammatory mediators to alleviate COVID-19 severity; a cross-section and in-silico study - Nature
• Scientists develop gene-edited wheat that can make toasted bread less carcinogenic - The Guardian
• Dual asparagine-depriving nanoparticles against solid tumors - Nature
• Asparagine-linked protein glycosylation: from... : Glycobiology - Ovid
• Polyglutamate-loaded chitosan nanogels reprogram plant metabolism for increased growth and viral resistance - Nature
• Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations - Nature
• Asparagine transporter supports macrophage inflammation via histone phosphorylation - Science | AAAS
• T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response - Nature
• Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells - Nature
• Asparagine bioavailability governs metastasis in a model of breast cancer - Nature
• Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor - Nature
• Gene-Edited Wheat Cuts Harmful Acrylamide Without Yield Loss - SeedWorld
• Asparagine availability controls germinal center B cell homeostasis - Science | AAAS
• Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase - Nature
• High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity - Nature
• Asparagine enhances LCK signalling to potentiate CD8 - Nature
• Asparagine bioavailability regulates the translation of MYC oncogene - Nature
• Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response - Nature
• p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival - Nature
• Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma - Nature
• Discovery of the biostimulant effect of asparagine and glutamine on plant growth in Arabidopsis thaliana - Frontiers
• CRISPR wheat cuts carcinogen risk without yield loss, strengthening case for precision gene editing - agnavigator.com
• Primary cilia sense glutamine availability and respond via asparagine synthetase - Nature
• Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling - JCI.org
• Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores - Nature
• Translational reprogramming marks adaptation to asparagine restriction in cancer - Nature
• Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition - Nature
• Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag - PNAS
• The ethical dilemma of GM crops - The Boar
• A census of glutamine/asparagine-rich regions: Implications for their conserved function and the prediction of novel prions - PNAS
• Clinical outcomes of two patients with a novel pathogenic variant in ASNS : response to asparagine supplementation and review of the literature - Nature
• 3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase - Nature
• Scientists develop gene-edited wheat that can make toasted bread less carcinogenic - Canada's National Observer
• Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Ceruleus Degeneration, and Hippocampal Amyloid-β42 Accumulation - Journal of Neuroscience
• Asparagine requirement in Plasmodium berghei as a target to prevent malaria transmission and liver infections - Nature
• Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding - Nature
• Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice - Nature
• Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway - Nature
• Saccharomyces cerevisiae ASN1 and ASN2 are asparagine synthetase paralogs that have diverged in their ability to polymerize in response to nutrient stress - Nature
• A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin - Nature
• To halt breast cancer’s spread, scientists block amino acid found in asparagus - UNC Health
• Gene-edited wheat cuts potential carcinogen in toast by up to 92% - 동아사이언스
• Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern - Nature
• LCK senses asparagine for T cell activation - Nature
• The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity - Nature
• An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2 - Nature
• Asparagine-mediated self-association of a model transmembrane helix - Nature
• Using CRISPR-Cas9 to knock out asparagine gene in wheat to reduce cancer risk - Phys.org
• Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors - Nature
• FAM49B Fragmentation by Asparagine Endopeptidase Promotes Vascular Smooth Muscle Cell Migration in Atherogenesis - American Heart Association Journals
• Cross-species analysis of apical asparagine-rich protein of Plasmodium vivax and Plasmodium knowlesi - Nature
• Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease - Nature
• Low-Asparagine Diet Could Slow Breast Cancer’s Spread - Genetic Engineering and Biotechnology News
• Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease - Wiley & Sons
• Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma - Nature
• Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations - Nature
• SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis - Nature
• AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis - Nature
• Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study - Haematologica
• -asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial - Nature
• Asparagine-modified magnetic graphene oxide as efficient green nanocatalyst for synthesis of chromenes and pyrano pyrazoles derivatives - Nature
• Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines - Staklinski - 2023 - JIMD Reports - Wiley Online Library
• Reply to Liu: Amino acid 104 asparagine/glutamic acid of p53 is an adaptively selected site for extreme environments in mammals of the Tibet plateau - PNAS
• NUCKS1, a LINC00629-upregulated gene, facilitated osteosarcoma progression and metastasis by elevating asparagine synthesis - Nature
• Nickel-asparagine complex fixed on a magnetic substrate as a precursor for preparing substituted acridines - Wiley Online Library
• A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant - Nature
• Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers - Nature
• Field assessment of genome‐edited, low asparagine wheat: Europe's first CRISPR wheat field trial - Wiley Online Library
• Spread of breast cancer linked to compound in asparagus and other foods - The Guardian
• Case Report: a novel homozygous ASNS variant in a Chinese female with severe microcephaly, encephalopathy and epilepsy - Frontiers
• Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7 - Nature
• Essential Role of Dengue Virus Envelope Protein N Glycosylation at Asparagine-67 during Viral Propagation - ASM Journals
• Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation | Circulation - American Heart Association Journals
• Study Finds Limiting Intake of Food With Asparagine Could Reduce Cancer Travel in Body - NBC Los Angeles
• Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease - Nature
• Structure of β-lactam synthetase reveals how to synthesize antibiotics instead of asparagine - Nature
• Manipulating a mouse’s diet can stop breast cancer spreading - Cancer Research UK - Cancer News
• Blocking amino acid found in asparagus stifles breast cancer - Futurity
• A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus - ASM Journals
• Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator‐Induced Brain Hemorrhagic Transformation After Ischemic Stroke - Xie - 2025 - CNS Neuroscience & Therapeutics - Wiley Online Library
• The protein with the largest single continuous stretch of asparagines in the proteome of P. falciparum - PLOS
• Asparagine endopeptidase cleaves tau and promotes neurodegeneration - Nature
• Planting the seeds of discovery: University of Missouri undergrad's quest for healthier food choices - Show Me Mizzou