Why is "Arp2/3 complex" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-19 16:30:36
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Arp2/3_complex entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-19 and was most recently seen on 2026-05-19.
Wikipedia Overview
Arp2/3 complex is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton. It is a major component of the actin cytoskeleton and is found in most eukaryotic cells.
Two of its subunits, the Actin-Related Proteins ARP2 and ARP3, closely resemble the structure of monomeric actin and serve as nucleation sites for new actin filaments. The complex binds to the sides of existing ("mother") filaments and initiates growth of a new ("daughter") filament at a distinctive 70-degree angle from the mother. Branched actin networks are created as a result of this nucleation of new filaments. The regulation of rearrangements of the actin cytoskeleton is important for processes like cell locomotion, phagocytosis, and the intracellular motility of lipid vesicles.
Related Topics
Trending Topic Today
Search Interest Perspective
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SLC7A11-mediated cystine accumulation and Rac1-WRC-Arp2/3-driven actin cytoskeletal folding synergistically induce disulfidptosis in acute myocardial infarction - Nature
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Control of microglial dynamics by the Arp2/3 complex and the autism- and schizophrenia-associated protein CYFIP1 - PNAS
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T-cell lamellipodial abnormalities and immune dysfunction - ASM Journals
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Study Overturns Decades of External Axon Growth Theory - Neuroscience News
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Mechanism of Arp2/3 complex branch disassembly by human Coro7 - Nature
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T-cell lamellipodial abnormalities and immune dysfunction - ASM Journals
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Dispensable players: N-WASP and WASP are not crucial for homology-directed DNA repair - Springer Nature Link
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ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning - Science | AAAS
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ARP2/3 localization in Arabidopsis leaf pavement cells: a diversity of intracellular pools and cytoskeletal interactions - Frontiers
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An intrinsic cytoskeletal oscillator establishes neuronal polarity - Nature
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ARP2/3 complex associates with peroxisomes to participate in pexophagy in plants - Nature
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Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction - Nature
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Molecular mechanism of Arp2/3 complex inhibition by Arpin - Nature
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Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation - Nature
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Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers - Nature
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The ARP2/3 complex: an actin nucleator comes of age - Nature
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Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state - Nature
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Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins - Nature
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An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature
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Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament - Nature
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Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF - Nature
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Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism - Science | AAAS
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Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry - PNAS
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Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks - Science | AAAS
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Arp2/3 and type-I myosins control chromosome mobility and end-resection at double-strand breaks in S. cerevisiae - Nature
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Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex - Nature
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New insights into the regulation and cellular functions of the ARP2/3 complex - Nature
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Cytoskeletal Oscillator Drives Neuronal Polarity Formation Intrinsically - Bioengineer.org
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Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy - PNAS
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Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo - The Company of Biologists
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Nuclear ARP2/3 drives DNA break clustering for homology-directed repair - Nature
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Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo - Nature
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ARP2/3-independent WAVE/SCAR pathway and class XI myosin control sperm nuclear migration in flowering plants - PNAS
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Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments - Nature
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Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging - PNAS
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Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs - Nature
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Regulation of focal adhesion formation by a vinculin-Arp2/3 hybrid complex - Nature
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The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex - Science | AAAS
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Inhibitory signalling to the Arp2/3 complex steers cell migration - Nature
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The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing - Journal of Neuroscience
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Isoform diversity in the Arp2/3 complex determines actin filament dynamics - Nature
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Photoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanism - PNAS
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Characterization of two classes of small molecule inhibitors of Arp2/3 complex - Nature
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Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination - Nature
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Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex - Nature
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Genetic dissection of the budding yeast Arp2/3 complex: A comparison of the in vivo and structural roles of individual subunits - PNAS
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WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes - Nature
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TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions - Nature
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Steps of actin filament branch formation by Arp2/3 complex investigated with coarse-grained molecular dynamics - Frontiers
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CRISPR-Cas9 Arabidopsis mutants of genes for ARPC1 and ARPC3 subunits of ARP2/3 complex reveal differential roles of complex subunits - Nature
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Lamellipodia Protrusion: Moving Interactions of Vinculin and Arp2/3 - ScienceDirect.com
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Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration - Nature
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Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease - Nature
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The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent - Journal of Neuroscience
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Identification of Arp2/3 Complex Subunits as Prognostic Biomarkers for Hepatocellular Carcinoma - Frontiers
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Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast - PNAS
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LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion - Nature
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Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions - Science | AAAS
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Structural basis for regulation of Arp2/3 complex by GMF - Nature
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The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration - Rockefeller University Press
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Disruption of Arp2/3 Results in Asymmetric Structural Plasticity of Dendritic Spines and Progressive Synaptic and Behavioral Abnormalities - Journal of Neuroscience
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Increased cross-presentation by dendritic cells and enhanced anti-tumour therapy using the Arp2/3 inhibitor CK666 - Nature
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Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation - PNAS
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How distinct Arp2/3 complex variants regulate actin filament assembly - Nature
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Biallelic loss of human CTNNA2 , encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration - Nature
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Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms - Nature
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p41‐Arc subunit of human Arp2/3 complex is a p21‐activated kinase‐1‐interacting substrate - Springer Nature Link
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The WASP-Arp2/3 complex signal cascade is involved in actin-dependent sperm nuclei migration during double fertilization in tobacco and maize - Nature
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Actin Nucleation: Cortactin Caught in the Act - ScienceDirect.com
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GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3 - Rockefeller University Press
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WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2 - Nature
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Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer - Nature
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Grab Your Partner with Both Hands: Cytoskeletal Remodeling by Arp2/3 Signaling - Science | AAAS
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Codependencies of mTORC1 signaling and endolysosomal actin structures - Science | AAAS
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Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes - Nature
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Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA, and actin filaments - PNAS
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Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase - Nature
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Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition - Rockefeller University Press
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Optogenetic actin network assembly on lipid bilayer uncovers the network density-dependent functions of actin-binding proteins - Nature
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Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments - PNAS
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Activation of Arp2/3 complex-mediated actin polymerization by cortactin - Nature
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Branched actin networks are organized for asymmetric force production during clathrin-mediated endocytosis in mammalian cells - Nature
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Arp2/3 ATP hydrolysis: to branch or to debranch? - Nature
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Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis - Science | AAAS
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Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches - PNAS
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Exo70 interacts with the Arp2/3 complex and regulates cell migration - Nature
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The RickA protein of Rickettsia conorii activates the Arp2/3 complex - Nature
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BPS Publications - British Pharmacological Society | Journals
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Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation - Nature
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A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks - Nature
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Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex - Nature
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Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3 - Nature
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Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis - Nature
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Mitochondria- and ER-associated actin are required for mitochondrial fusion - Nature
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Dynamic Nuclear Actin Assembly by Arp2/3 Complex and a Baculovirus WASP-Like Protein - Science | AAAS
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Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex - Nature
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The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments - Nature
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Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization - Nature
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Conformational changes in the Arp2/3 complex leading to actin nucleation - Nature
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The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors - Nature
Why This Topic Is Trending
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.