Why is "Aromatase" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-15 12:24:26
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Aromatase entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-15 and was most recently seen on 2026-03-15.
Wikipedia Overview
Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The enzyme aromatase can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.
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Trending Topic Today
Search Interest Perspective
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Is Excess Adiposity Linked to Vertebral Fracture Progression in Aromatase Inhibitor–Treated Early Breast Cancer? - The ASCO Post
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When to Replace Aromatase Inhibitors With SERDs in ER+/HER2– Advanced mBC - CancerNetwork
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Aromatase Inhibitors Favored as Adjuvant ET in HR+/HER2+ Early Breast Cancer - Targeted Oncology
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Nodular Vasculitis Following Aromatase Inhibitor Therapy for Breast Cancer: A Case Report - Cureus
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Combination Ribociclib and Aromatase Inhibitors in Metastatic Breast Cancer: A Retrospective Real-World Analysis - Docwire News
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An integrated computational, in vitro and metabolomics approach to the discovery of novel aromatase inhibitors with anti-breast cancer activities - Nature
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Ribociclib Plus Aromatase Inhibitor Delays Postprogression Events in HR+/HER2− Metastatic Breast Cancer - Oncodaily
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Kisqali Plus Aromatase Inhibitor Shows Long-Term Benefit in Early Breast Cancer - Cure Today
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Bone Loss with Exemestane Found to Be Temporary &... : Oncology Times - Ovid
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Five Things to Reduce Side Effects from Most Common Breast Cancer Treatment - University of Rochester
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Consensus: Bisphosphonates for Aromatase Inhibitor Bone Loss - Medscape
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Toxicity Profiles and Real-World Data Guide CDK4/6 Inhibitor Selection for Metastatic Breast Cancer - OncLive
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Aromatase Inhibitor Therapy Improves Long-Term Survival in HR-Positive, HER2-Positive Early Breast Cancer - HMP Global Learning Network
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Nonmetastatic Breast Cancer Treatment Strategies After Denosumab Discontinuation in Patients Treated With Aromatase Inhibitors - The ASCO Post
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Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes - Endocrine Society
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105 Real-World Overall Survival With Palbociclib Plus an Aromatase Inhibitor (AI) in Overweight/Obese Patients With HR+/HER2− Metastatic Breast Cancer (MBC) - CancerNetwork
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Grade 3 Dermatitis Secondary to Two Aromatase Inhibitors in Early Hormone Receptor-Positive Breast Cancer: A Case Report - Cureus
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SERENA-6 Supports Early Switch to Camizestrant After ESR1 Mutation Emergence - Docwire News
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122 Adjuvant Ribociclib (RIB) Plus Nonsteroidal Aromatase Inhibitor (NSAI) in Patients With HR+/HER2− Early Breast Cancer (EBC): NATALEE 5-Year Outcomes - CancerNetwork
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124 Real-World Progression-Free Survival 2 and Tumor Response of CDK4/6is + Aromatase Inhibitor in Patients With HR+/HER2– Metastatic Breast Cancer - CancerNetwork
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Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation - Asia Research News |
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Adjuvant Ribociclib Plus AI Therapy Has Long-Term Activity in HR+, HER2-Negative Early Breast Cancer - OncLive
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Breast Cancer Therapy Associated with Punctate Epitheliopathy - Review of Optometry
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Molecular and clinical effects of aromatase inhibitor therapy on skeletal muscle function in early-stage breast cancer - Nature
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SERENA-6 Trial Validates Molecular-Guided Therapy Switch to Camizestrant - The American Journal of Managed Care
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Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years - The New England Journal of Medicine
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Oestradiol and breast cancer prevention: a 40 year history and contemporary perspective | British Journal of Cancer - Nature
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Molecular profiling of aromatase inhibitor sensitive and resistant ER+HER2- postmenopausal breast cancers - Nature
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Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer - The New England Journal of Medicine
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Breast cancer survivors find relief for debilitating menopause symptom - Mayo Clinic News Network
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Vaginal microbiomes of breast cancer survivors treated with aromatase inhibitors with and without vulvovaginal symptoms - Nature
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New Recommendations Released for Managing Aromatase Inhibitor–Induced Bone Loss - The ASCO Post
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HR-positive, HER2-negative advanced breast cancer: fovinaciclib plus aromatase inhibitor prolongs first-line PFS - Vera Health
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Muna Al-Khaifi: The Hidden Fracture Risk Behind Body Fat in Breast Cancer - Oncodaily
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Aromatase Inhibitor Therapy: How Long Is Best - Beth Israel Deaconess Medical Center
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Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype - Nature
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Aromatase inhibitors for breast cancer: lessons from the laboratory - Nature
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Aromatase Inhibitor Therapy Increases the Risk of New-Onset Atrial Fibrillation in Patients With Breast Cancer - JACC Journals
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Estrogen Excess Associated with Novel Gain-of-Function Mutations Affecting the Aromatase Gene - The New England Journal of Medicine
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Adverse Effects of Aromatase Inhibition on the Brain and Behavior in a Nonhuman Primate - Journal of Neuroscience
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Aromatase inhibitors better than tamoxifen at reducing risk of breast cancer recurrence in premenopausal and postmenopausal women - ndph.ox.ac.uk
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Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer - Nature
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Extended aromatase inhibitor therapy reduces breast cancer recurrence in postmenopausal women - 2 Minute Medicine
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Aromatase Inhibitors in Breast Cancer - The New England Journal of Medicine
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Tamoxifen or aromatase inhibitors with ovarian function suppression in pre-menopausal stage I-III lobular breast cancer - Nature
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Association between aromatase in human brains and personality traits - Nature
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Aromatase inhibitors and fracture prevention – do 2017 guidelines work in real world? - Nature
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Management of Aromatase Inhibitor–Induced Musculoskeletal Symptoms: A Physiatric Approach - The ASCO Post
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Extending aromatase inhibitor treatment in early breast cancer; longer is better for many - The Lancet
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Aromatase Inhibitors May Boost Height in Short Pubertal Boys - Medscape
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Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy - The Lancet
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Carryover effects of aromatase inhibitors in prevention - The Lancet
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Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers - Nature
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In-silico and in-vitro study reveals ziprasidone as a potential aromatase inhibitor against breast carcinoma - Nature
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Cotargeting of CYP-19 (aromatase) and emerging, pivotal signalling pathways in metastatic breast cancer - Nature
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Finding the ‘Right Fit’ for ER+ Breast Cancer After Aromatase Inhibitor AEs - Oncology Nursing News
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Vaginal Estrogen Therapy May Increase Risk of Recurrence in Breast Cancer Patients Treated With Aromatase Inhibitors - Cancer Therapy Advisor
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Real-world effectiveness of palbociclib plus an aromatase inhibitor in HR+/HER2− MBC patients living in disadvantaged neighborhoods - Nature
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Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer - Nature
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Endocrine Therapy With Aromatase Inhibitor for Postmenopausal Women With Breast Cancer - The ASCO Post
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Efficient sex hormone biosensors in Saccharomyces cerevisiae cells to evaluate human aromatase activity and inhibition - Nature
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Effects of cigarette smoke extract on angiogenesis and aromatase activity in KGN cells - Nature
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The Link Between Aromatase Inhibition and Neuropsychological Symptoms in Early-Stage Breast Cancer - Oncology Nurse Advisor
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SERPINA3-ANKRD11-HDAC3 pathway induced aromatase inhibitor resistance in breast cancer can be reversed by HDAC3 inhibition - Nature
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Evidence Supports Ovarian Function Suppression Plus Aromatase Inhibitor in Premenopausal Women With Early Breast Cancer - The ASCO Post
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1 Elacestrant Versus Fulvestrant or Aromatase Inhibitor in a Phase 3 Trial Evaluating Elacestrant, an Oral Selective Estrogen Receptor Degrader Versus Standard-of- Care Endocrine Monotherapy for ER+/HER2– Advanced/Metastatic Breast Cancer - CancerNetwork
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Aromatase inhibitors cut breast cancer recurrence in younger patients - Cancer Research UK - Cancer News
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Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials - The Lancet
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Aromatase Inhibitors Raise Retinal Adverse Event Risk - Ophthalmology Advisor
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Overall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer - The New England Journal of Medicine
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Aromatase inhibitors in breast cancer linked to bone fracture risk - Contemporary OB/GYN
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Neuro-immune-endocrine mechanisms with poor adherence to aromatase inhibitor therapy in breast cancer - Frontiers
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Adjuvant Denosumab Improves Long-term Survival and Bone Protection in Patients With Early-Stage Breast Cancer Taking Aromatase Inhibitors - ASCO Daily News
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Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women’s breast tissue | Scientific Reports - Nature
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Blood test provides early warning of resistance to aromatase inhibitors - Oncology Central
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The beneficial androgenic action of steroidal aromatase inactivators in estrogen-dependent breast cancer after failure of nonsteroidal drugs - Nature
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Desescalation in Aromatase Inhibitors prescription for menopausal women with positive hormonal receptors breast cancers | Medical Research Archives - European Society of Medicine
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For Some Breast Cancer Survivors, Drug May Reduce Treatment-Related Joint Pain - National Cancer Institute (.gov)
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Using Aromatase Inhibitors for the Treatment of Endometriosis - Contemporary OB/GYN
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Corneal changes in estrogen-dependent breast cancer after hormonal treatment - Nature
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Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms - Wiley & Sons
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PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs | Scientific Reports - Nature
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Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay - Nature
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Study Examines Aromatase Inhibitor–Associated Musculoskeletal Symptoms in a Diverse Population With Early Breast Cancer - The ASCO Post
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Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses - Frontiers
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Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors - Nature
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New Study Looks at Link Between Estrogen Level and Breast Cancer - Sutter Health
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Long-Term Outcomes of Adjuvant Denosumab in Breast Cancer - NEJM Evidence
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A case of aromatase inhibitor-induced alopecia successfully treated with low-dose oral minoxidil - Wiley Online Library
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What Are Aromatase Inhibitors? - Dana-Farber Cancer Institute
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Knockout of Zebrafish Ovarian Aromatase Gene ( cyp19a1a ) by TALEN and CRISPR/Cas9 Leads to All-male Offspring Due to Failed Ovarian Differentiation - Nature
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New study shows breast tumors evolve in response to hormone therapy - WashU Medicine
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Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer - The New England Journal of Medicine
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Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome - Nature
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22 Efficacy and Safety of Ribociclib + Nonsteroidal Aromatase Inhibitor in Younger Patients With HR+/HER2− Early Breast Cancer in NATALEE - CancerNetwork
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Capecitabine with aromatase inhibitors in the front-line therapy for metastatic breast cancer - Springer Nature Link
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Aromatase Inhibitors Show Greater Benefit in Preventing Contralateral Breast Cancer - Pharmacy Times
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Extended Adjuvant Therapy Beneficial for Some Women with Breast Cancer - National Cancer Institute (.gov)
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Whole-genome analysis informs breast cancer response to aromatase inhibition - Nature
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Acupuncture May Reduce Treatment-Related Joint Pain for Breast Cancer Patients - National Cancer Institute (.gov)
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.