Why is "Aquaporin-3" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-07 16:57:29
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Aquaporin-3 entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-07 and was most recently seen on 2026-06-07.
Wikipedia Overview
Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers. In the kidney, aquaporin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. This protein is also a determinant for the GIL blood group system.
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Trending Topic Today
Search Interest Perspective
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Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism - Nature
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Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review - Frontiers
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Obinutuzumab β for aquaporin-4-positive neuromyelitis optica spectrum disorder: a phase 3 randomized controlled trial - Nature
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A Novel Moisturizer for Extra Dry Skin - dermatologytimes.com
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Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling - PNAS
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The water channels aquaporin-1 and aquaporin-3 interact with and affect the cell polarity protein Scribble in 3D in vitro models of breast cancer - American Physiological Society Journal
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Magnesium Compounds Increase Aquaporin-3 in Human Epidermal Keratinocyte HaCaT Cells - Wiley Online Library
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Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels - PNAS
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Sesamol regulates AQP3 and HAS2 via MAPK signaling for skin barrier protection an in vitro and molecular docking study - Nature
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Blockage of aquaporin-3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration - Wiley & Sons
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Mechanisms of Aquaporin-Facilitated Cancer Invasion and Metastasis - Frontiers
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Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice - PNAS
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Aquaporins: New players in breast cancer progression and treatment response - Frontiers
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Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression - Nature
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Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis - Nature
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Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury - Nature
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Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma - Nature
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Aquaporin 3 facilitates chemoresistance in gastric cancer cells to cisplatin via autophagy - Nature
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Identification of Estrogen Response Element in Aquaporin-3 Gene that Mediates Estrogen-induced Cell Migration and Invasion in Estrogen Receptor-positive Breast Cancer - Nature
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Salinity effects on expression and localization of aquaporin 3 in gills of the euryhaline milkfish ( Chanos chanos - Wiley Online Library
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Blockage of aquaporin-3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration - Wiley & Sons
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A region within the third extracellular loop of rat Aquaporin 6 precludes trafficking to plasma membrane in a heterologous cell line - Nature
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APMIS | Medical Research Journal - Wiley Online Library
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Inhibition of the aquaporin 3 water channel increases the sensitivity of prostate cancer cells to cryotherapy - Nature
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A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells - American Physiological Society Journal
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Narrowed pore conformations of aquaglyceroporins AQP3 and GlpF - Nature
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New Perspectives on the Potential Role of Aquaporins (AQPs) in the Physiology of Inflammation - Frontiers
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The skin hydration and anti-ageing benefits of Ectoine, achieved through enhanced Src-ERK-mediated HAS-2 and JNK-driven AQP-3 expression in human keratinocytes, along with the inhibition of MMP-1-induced collagen-I degradation in human fibroblasts, - Wiley Online Library
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AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M - Nature
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PPAR-γ/NF-kB/AQP3 axis in M2 macrophage orchestrates lung adenocarcinoma progression by upregulating IL-6 - Nature
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Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases - Frontiers
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Helicobacter pylori infection promotes Aquaporin 3 expression via the ROS–HIF-1α–AQP3–ROS loop in stomach mucosa: a potential novel mechanism for cancer pathogenesis - Nature
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Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration - Nature
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Aquaporins in Cancer Biology - Frontiers
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Aquaporins in sepsis- an update - Frontiers
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Poly-γ-glutamic acid alleviates slow transit constipation by regulating aquaporin and gut microbes - Nature
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A persulfidation-based mechanism controls aquaporin-8 conductance - Science | AAAS
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Following the cellular itinerary of renal aquaporin-2 shuttling with 4.5x expansion microscopy - American Physiological Society Journal
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Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence - PNAS
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Long-term regulation of four renal aquaporins in rats - American Physiological Society Journal
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An aquaporin mediates cell shape change required for cellular immunity in the beet armyworm, Spodoptera exigua - Nature
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Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization - Nature
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Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility - Nature
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Aquaglyceroporins: Drug Targets for Metabolic Diseases? - Frontiers
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Aquaporins in sperm osmoadaptation: an emerging role for volume regulation - Nature
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The Perinatal Expression of Aquaporin-2 and Aquaporin-3 in Developing Kidney - Nature
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The Role of Aquaporins in the Kidney of Euryhaline Teleosts - Frontiers
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Testosterone Enhances Wound Healing and Stress Resistance in A549 Lung Adenocarcinoma Cells via Actin Remodeling and AQP3 Upregulation - Wiley Online Library
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Glycerin is safe, effective in psoriasis model - EurekAlert!
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Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity - Nature
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Malaria-Causing Parasite Manipulates Liver Cells to Survive - Duke Today
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Why Aquaporins Are Making Their Way Into the Skin-Care Conversation - Allure
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Dual-action fermented oats (Avena sativa L.): Anti-inflammatory and skin barrier restoration - EurekAlert!
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Transepidermal Water Loss in Developing Rats: Role of Aquaporins in the Immature Skin - Nature
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Cancer drug might help with skin disease - The Augusta Chronicle
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The simple secret to super-hydrated skin - News.com.au
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Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis - PNAS
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.