Why is "Antifolate" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-24 10:07:49
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
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Wikipedia Overview
Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).
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Trending Topic Today
Search Interest Perspective
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Byondis to Present Data from its Novel ADC Technology Platforms at the American Society for Cancer Research Meeting 2026 - BioSpace
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Targeting Parasitic DHFR: Montclair State Students Advance Antifolate Drug Discovery for Lymphatic Filariasis - Montclair State University
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Structural basis of antifolate recognition and transport by PCFT - Nature
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Effects of Antifolate Drugs on the Cellular Uptake of Radiofolates In Vitro and In Vivo - Journal of Nuclear Medicine
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Pemetrexed disodium, a novel antifolate with multiple targets - ScienceDirect.com
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The unsung Indian scientist who helped create chemotherapy and redefined cancer care - India Today
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Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors - Science | AAAS
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Effects of Metformin Combined With Antifolates on HepG2 Cell Metabolism and Cellular Proliferation - Frontiers
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The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibiotics - Nature
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Effects of Antifolate Drugs on the Cellular Uptake of Radiofolates In Vitro and In Vivo - Journal of Nuclear Medicine
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Metformin and cancer: Between the bioenergetic disturbances and the antifolate activity - ScienceDirect.com
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Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest - Nature
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MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers - Nature
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Targeted therapy of pyrrolo[2,3- d ]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment - Nature
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Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors - Nature
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Postmarketing safety evaluation of pemetrexed using FAERS and JADER databases - Nature
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Folate transporter dynamics and therapy with classic and tumor-targeted antifolates - Nature
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Folate metabolism: a re-emerging therapeutic target in haematological cancers - Nature
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Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport - Nature
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Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax - Nature
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Receptor-targeted antifolate drugs yield fewer side effects - Fierce Pharma
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Resistance to antifolates - Nature
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Targeting intracellular p -aminobenzoic acid production potentiates the anti-tubercular action of antifolates - Nature
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Discovery – Methotrexate: Chemotherapy Treatment for Cancer - National Cancer Institute (.gov)
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Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance - Wiley Online Library
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Pemetrexed Improves Tumor Selectivity of 111In-DTPA-Folate in Mice with Folate Receptor–Positive Ovarian Cancer - Journal of Nuclear Medicine
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High folic acid supplementation associated with higher rates of COVID-19 infections and mortality - Medical Xpress
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Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target - PNAS
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Federal Circuit Cautions Against Rigid Approach to Prosecution History Estoppel in Fourth Appeal from ALIMTA® Litigations - Mintz
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Anti-folates potentiate bactericidal effects of other antimicrobial agents | The Journal of Antibiotics - Nature
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UCP-1162 for cancer and autoimmune therapies - BioWorld News
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Listeria monocytogenes folate metabolism is required to generate N-formylmethionine during infection - ASM Journals
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Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models - Nature
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C. parvum gets the CRISPR upgrade - Nature
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Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA - Nature
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Anti-Malarial Drugs Market Size, Share | CAGR of 4.1% - Market.us
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γ -Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate - Nature
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CAFC Affirms Prosecution History Estoppel Does Not Bar Eli Lilly from Asserting Infringement Under the Doctrine of Equivalents - IPWatchdog.com
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Update on Novel Treatments for Peripheral T-cell Lymphoma - The ASCO Post
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Weekly Dose: methotrexate, the anti-inflammatory drug that can kill if taken daily - The Conversation
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Bacterial Immune System Makes Them More Susceptible to Antibiotics - Technology Networks
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Single agent and combination studies of pralatrexate and molecular correlates of sensitivity - Nature
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Methotrexate-associated oral mucositis in children with acute lymphoblastic leukemia - Via Medica Journals
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Mesothelioma Therapy Could Lead to Painful Skin Condition - mesotheliomahelp.org
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Resistance to Antimalarial Drugs: Molecular, Pharmacologic, and Clinical Considerations - Nature
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Kellogg's Product 19 - University of Delaware
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People With High Folic Acid Supplementation More Likely To Get COVID-19 And Die From It: Study - TheHealthSite
Why This Topic Is Trending
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