Why is "Amyloid precursor protein" trending?

Search Interest Perspective

• Virus-mediated gene transfer of soluble amyloid precursor protein-alpha via systemic injection in a mouse model of Alzheimer’s disease | Gene Therapy - Nature
• Negative interplay between HIV-1 Gag and amyloid precursor protein centers around competition for VPS4A and TSG101 - PNAS
• Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level - Frontiers
• Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice - Wiley Online Library
• The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment - Journal of Neuroscience
• Recognition of the amyloid precursor protein by human γ-secretase - Science | AAAS
• Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits - Nature
• Amyloid Precursor Protein Can Cause Changes in Neuronal Firing Rates via Axon Initial Segment - Journal of Neuroscience
• Iron responsive elements mRNA regulate Alzheimer’s amyloid precursor protein translation through iron sensing - Frontiers
• Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics - Nature
• Neurexin-β Mediates the Synaptogenic Activity of Amyloid Precursor Protein - Journal of Neuroscience
• Knockdown of Amyloid Precursor Protein: Biological Consequences and Clinical Opportunities - Frontiers
• Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity - Nature
• The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses - Journal of Neuroscience
• Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging - Nature
• Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons - Journal of Neuroscience
• The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease | Cell Death & Disease - Nature
• Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish - Nature
• Pharmacological targeting of the β-amyloid precursor protein intracellular domain - Nature
• Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission - Nature
• A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase - Nature
• Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system - Nature
• Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα - Frontiers
• Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain - Nature
• Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688 - PNAS
• Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein - Wiley Online Library
• Histone deacetylase-3 regulates the expression of the amyloid precursor protein and its inhibition promotes neuroregenerative pathways in Alzheimer's disease models - Wiley
• Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway - Nature
• β-Secretase Cleavage of the Fly Amyloid Precursor Protein Is Required for Glial Survival - Journal of Neuroscience
• Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts - Journal of Neuroscience
• Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling - Nature
• Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum - Nature
• Retraction: An aberrant phosphorylation of amyloid precursor protein tyrosine regulates its trafficking and the binding to the clathrin endocytic complex in neural stem cells of Alzheimer's disease patients - Frontiers
• Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach - Nature
• The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish - Nature
• Physiological role for amyloid precursor protein in adult experience-dependent plasticity - PNAS
• Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein - Journal of Neuroscience
• Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation - PNAS
• Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration - Journal of Neuroscience
• Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles - PNAS
• Soluble amyloid precursor protein β as blood-based biomarker of Alzheimer’s disease - Nature
• TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes - Rockefeller University Press
• Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis - Nature
• Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC-Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology - Frontiers
• Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer’s disease - Nature
• Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein - Journal of Neuroscience
• Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation - Nature
• Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease - Nature
• Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta - Nature
• HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration - Nature
• Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2 - Journal of Neuroscience
• Altered Concentrations of Amyloid Precursor Protein Metabolites in the Cerebrospinal Fluid of Patients with Bipolar Disorder - Nature
• Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation - Nature
• The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method | Scientific Reports - Nature
• Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production - Journal of Neuroscience
• Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 - Frontiers
• Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease - Journal of Neuroscience
• FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis - Journal of Neuroscience
• Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis - Journal of Neuroscience
• Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments - Neurology® Journals
• Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing - Nature
• Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons - Nature
• Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice - Nature
• The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol - Science | AAAS
• Pulsatile stretch as a novel modulator of amyloid precursor protein processing and associated inflammatory markers in human cerebral endothelial cells | Scientific Reports - Nature
• Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis - Journal of Neuroscience
• Amyloid Precursor Protein in Drosophila Glia Regulates Sleep and Genes Involved in Glutamate Recycling - Journal of Neuroscience
• Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein | Communications Biology - Nature
• The role of leptin in regulation of the soluble amyloid precursor protein α (sAPPα) levels in lung cancer cell media - Nature
• Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus - Frontiers
• Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis - Nature
• The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice - Journal of Neuroscience
• HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA - Nature
• β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis - Journal of Neuroscience
• Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation - Nature
• Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct - PNAS
• LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking - Journal of Neuroscience
• Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology - Nature
• The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling - PNAS
• Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors - Nature
• Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease - Science | AAAS
• Scientists Offer New Alzheimer’s, Amyloid Connection Theory - Florida Atlantic University
• Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease - PNAS
• Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing - Journal of Neuroscience
• Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology - PNAS
• Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention - Nature
• Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure−activity relationship with a strong BBB permeability - Nature
• Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice - PNAS
• Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice - Nature
• Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase - PNAS
• Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms - PNAS
• Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression - PNAS
• Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism - Wiley Online Library
• The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus - PNAS
• Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex - Nature
• Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth - Journal of Neuroscience
• Fasciclin II Signals New Synapse Formation through Amyloid Precursor Protein and the Scaffolding Protein dX11/Mint - Journal of Neuroscience
• Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains - Science | AAAS
• Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting Protein In Vivo That Modulates Amyloidogenic Processing In Vitro - Journal of Neuroscience
• Amyloid beta: structure, biology and structure-based therapeutic development | Acta Pharmacologica Sinica - Nature