Why is "Aminopterin" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-31 14:17:25
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Aminopterin entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-31 and was most recently seen on 2026-03-31.
Wikipedia Overview
Aminopterin, the 4–amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.
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Trending Topic Today
Search Interest Perspective
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Antifolate agent aminopterin demonstrates potent anti-monkeypox virus activity in vitro and in vivo - ASM Journals
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Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin) - NEJM
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Optimizing our Success - Harvard Medical School
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Further case of aminopterin syndrome sine aminopterin in a Spanish child - Wiley Online Library
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Scurvy Following Folic Acid Antagonist Therapy - RSNA Journals
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We made great strides with childhood leukaemia – we can do the same for brain cancer - The Conversation
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Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest - Nature
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Drug Therapeutics & Regulation in the U.S. - fda.gov
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Investigators Confirm Deadly Pet Food Contaminated With Rat Poison - ABC News - Breaking News, Latest News and Videos
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The unsung Indian scientist who helped create chemotherapy and redefined cancer care - India Today
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Sixty Years Ago, a Rash of Mysterious Birth Defects Spurred a Doctor’s Search for Answers - National Endowment for the Humanities (.gov)
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Sidney Farber, Chemo Crusader - WNYC
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Folate Receptor-targeting Drug Seen to Lessen Inflammation in MS Rat Study - Multiple Sclerosis News Today
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The road to cancer treatment through clinical trials - Worcester Telegram
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Worried local animal owners turning to homemade pet food - Times Herald-Record
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Pet Food Contained Chemical Found in Plastic, F.D.A. Says (Published 2007) - The New York Times
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Unmasking the toxic culprit(s) in pet-food recalls - DVM360
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Rat Poison Found in Recalled Pet Food - ABC News - Breaking News, Latest News and Videos
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Pet Food Maker to Take Financial Responsibility for Pet Deaths From Poisoning - ABC News - Breaking News, Latest News and Videos
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Chemistry Abbreviations Starting with H and I - ThoughtCo
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Remembering the forgotten Indian biochemist who made pioneering contributions to cancer treatment - Scroll.in
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.