Why is "Alpha-interferon" trending?
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- Date: 2026-04-10 05:19:12
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Wikipedia Overview
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα, IFNω (IFNW1), IFNɛ (IFNE), IFNк (IFNK) and IFNβ (IFNB1), plus 11 IFN pseudogenes.
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Search Interest Perspective
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Interferons in HIV-1 infection: mechanisms, antiviral potentials, and therapeutic challenges - Frontiers
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Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX) - Nature
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Full article: Influenza A virus-induced interferon-alpha production by myeloid dendritic cells and macrophages requires productive infection - Taylor & Francis Online
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Interferon Alpha Nasal Spray Decreases COVID-19 Risk in Those With Cancer - CancerNetwork
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Interferon-α Nasal Spray Safely Lowers COVID-19 Risk in Patients With Cancer - Vaccine Advisor
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New data: Interferon-alpha nasal spray cuts COVID infections in adult cancer patients by 40% - CIDRAP
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Comparison of anxiety symptoms in patients with myeloproliferative neoplasms treated with interferon alpha and tyrosine kinase inhibitors | Gibek | Acta Haematologica Polonica - Via Medica Journals
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Identification of hub six interferon alpha response genes and immune cell infiltration characteristics in low-grade glioma - Nature
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Interferon for MPNs - Pegasys available from July - Blood Cancer UK
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Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays - PNAS
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Successful use of interferon alfa-2a for persistent parvovirus B19 infection - The Lancet
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Interferon alpha Nasal Spray Reduces COVID-19 Risk in Cancer Patients: Study - Medical Dialogues
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Stanford Medicine researchers lead clinical trial of interferon-lambda for COVID-19 - Stanford Medicine
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Interferon and Hepatitis B: Current and Future Perspectives - Frontiers
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Investigation into the pharmacodynamics and pharmacokinetics of recombinant human interferon alfa-2b vaginal suppository following process optimization in chinese rhesus macaque - Nature
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Interferon therapy and its association with depressive disorders – A review - Frontiers
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Interferon-alpha therapy for refractory kaposiform hemangioendothelioma: a single-center experience - Nature
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Asian elephant interferons alpha and beta and their anti-herpes viral activity - Frontiers
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Long-term outcomes of polycythemia vera patients treated with ropeginterferon Alfa-2b - Nature
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Interferon-α Subtypes As an Adjunct Therapeutic Approach for Human Immunodeficiency Virus Functional Cure - Frontiers
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Interferon-α and survival in metastatic renal carcinoma: early results of a randomised controlled trial - The Lancet
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A weak signal for strong responses: interferon-alpha/beta revisited - Nature
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Development of latent Interferon alpha 2b as a safe therapeutic for treatment of Hepatitis C virus infection - Nature
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Recurrence of depressive disorders after interferon-induced depression - Nature
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Type I interferons in infectious disease - Nature
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Pegylated interferon alfa-2a (Pegasys): Supply issue - Pharmac
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Antiviral activity of mink interferon alpha expressed in the yeast Pichia pastoris - Frontiers
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TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells - Nature
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Evaluation of modified Interferon alpha mRNA constructs for the treatment of non-melanoma skin cancer - Nature
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Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection - Frontiers
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Probable involvement of p11 with interferon alpha induced depression - Nature
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Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice - Frontiers
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Effect of interferon therapy on quality of life in patients with chronic hepatitis B - Nature
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Should interferons take front stage as an essential MS disease-modifying therapy in the era of coronavirus disease 2019? - Neurology® Journals
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The Dual Nature of Type I and Type II Interferons - Frontiers
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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells - Nature
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Detection of interferon alpha protein reveals differential levels and cellular sources in disease - Rockefeller University Press
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Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human macrophages and blunt glycolysis in response to antigenic stimuli - Wiley Online Library
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Targeting type I interferons in systemic lupus erythematous - Frontiers
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Interferon-α Therapy Associated With the Development of Sarcoidosis - ScienceDirect.com
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Antitumor potential of a synthetic interferon-alpha/PLGF-2 positive charge peptide hybrid molecule in pancreatic cancer cells - Nature
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STAT2 Is a Primary Target for Measles Virus V Protein-Mediated Alpha/Beta Interferon Signaling Inhibition - ASM Journals
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Nephrectomy Followed by Interferon Alfa-2b Compared with Interferon Alfa-2b Alone for Metastatic Renal-Cell Cancer - The New England Journal of Medicine
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In vitro replicative fitness of early Transmitted founder HIV-1 variants and sensitivity to Interferon alpha - Nature
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An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1 - Frontiers
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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells - Nature
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Breaking down the cellular responses to type I interferon neurotoxicity in the brain - Frontiers
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Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication - ASM Journals
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Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons - ASM Journals
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Abu-Zeinah Outlines Why Interferon-Alpha Should Be Offered to Both Low- and High-Risk Polycythemia Vera - OncLive
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Inflammation Activates the Interferon Signaling Pathways in Taste Bud Cells - Journal of Neuroscience
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Type I Interferons and Natural Killer Cell Regulation in Cancer - Frontiers
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Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions - Nature
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Transcriptional Activation of Alpha/Beta Interferon Genes: Interference by Nonsegmented Negative-Strand RNA Viruses - ASM Journals
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Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C - ScienceDirect.com
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Detection of interferon alpha protein reveals differential levels and cellular sources in disease - Rockefeller University Press
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Interferon Alpha in Systemic Lupus Erythematosus - Niewold - 2010 - BioMed Research International - Wiley Online Library
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Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C - The New England Journal of Medicine
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Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV - Nature
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Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease - Frontiers
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Treatment of Acute Hepatitis C with Interferon Alfa-2b - The New England Journal of Medicine
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Interferon-α and -β differentially regulate osteoclastogenesis: Role of differential induction of chemokine CXCL11 expression - PNAS
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Interferons for Hepatitis C: Understanding the Long-Term Side Effects - Healthline
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NK cells are associated with HBV control during pegylated-interferon-alpha-2b therapy of chronic hepatitis B - Nature
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Interferon-Alpha Reduces Myelofibrosis Risk, Mortality Rate in Low- and High-Risk Polycythemia Vera - OncLive
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Psychiatric Clearance for Patients Started on Interferon-Alpha-Based Therapies | American Journal of Psychiatry - Psychiatry Online
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Circulating miR-210 and miR-22 combined with ALT predict the virological response to interferon-alpha therapy of CHB patients - Nature
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Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox - Nature
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Sirolimus combined with interferon-alpha 2b therapy for giant hepatic epithelioid hemangioendothelioma: a case report - Frontiers
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Human alpha and gamma interferon analogs in rabbits with herpetic keratitis. - ARVO Journals
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Clinicohematologic and molecular response of essential thrombocythemia patients treated with pegylated interferon-α: a multi-center study of the German Study Group-Myeloproliferative Neoplasms (GSG-MPN) | Leukemia - Nature
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IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy - Nature
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Protective Role of Beta Interferon in Host Defense against Influenza A Virus - ASM Journals
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Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma | British Journal of Cancer - Nature
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Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells - Nature
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Treatment of Chronic Hepatitis D with Interferon Alfa-2a - The New England Journal of Medicine
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Interferon Alfa-2a as Compared with Conventional Chemotherapy for the Treatment of Chronic Myeloid Leukemia - The New England Journal of Medicine
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Interferon-Alpha Improves MFS and OS Over Standard Approaches in Polycythemia Vera - OncLive
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Interferon and anti-TNF therapies differentially modulate amygdala reactivity which predicts associated bidirectional changes in depressive symptoms - Nature
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Targeted mutations in IFNα2 improve its antiviral activity against various viruses - ASM Journals
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Suppression of Cell Proliferation by Interferon-Alpha through Interleukin-1 Production in Adult Rat Dentate Gyrus - Nature
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Clinical Guidelines for the Medical Management of Hepatitis C - New York State Department of Health (.gov)
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Interferons α and β in cancer: therapeutic opportunities from new insights - Nature
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Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma - The New England Journal of Medicine
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Immunoreduction of ocular surface tumours with intralesional interferon alpha-2a - Eye - Nature
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Interferon-alpha for treating polycythemia vera yields improved myelofibrosis-free and overall survival | Leukemia - Nature
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IFN-β induces greater antiproliferative and proapoptotic effects and increased p53 signaling compared with IFN-α in PBMCs of Adult T-cell Leukemia/Lymphoma patients - Nature
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Maintenance Treatment with Recombinant Interferon Alfa-2b in Patients with Multiple Myeloma Responding to Conventional Induction Chemotherapy - The New England Journal of Medicine
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Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma - The New England Journal of Medicine
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Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation - Rockefeller University Press
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Interferon Alfa-2b Alone or in Combination with Ribavirin for the Treatment of Relapse of Chronic Hepatitis C - The New England Journal of Medicine
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Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1 - Nature
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The latest in the treatment of OSSN - EyeWorld
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Antibodies Neutralizing Peginterferon Alfa during Retreatment of Hepatitis C - The New England Journal of Medicine
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Targeted mutations in IFNα2 improve its antiviral activity against various viruses - ASM Journals
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Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy - The New England Journal of Medicine
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Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling - PNAS
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Interferons in Traumatic Brain and Spinal Cord Injury: Current Evidence for Translational Application - Frontiers
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Prognostic Significance of Autoimmunity during Treatment of Melanoma with Interferon - The New England Journal of Medicine
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Dr. Abu-Zeinah on the Efficacy of Interferon-Alpha in Polycythemia Vera - OncLive
Why This Topic Is Trending
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