Why is "Aldosterone" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-07 07:55:11
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Aldosterone entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-07 and was most recently seen on 2026-03-07.
Wikipedia Overview
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na+), and potassium (K+) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. It influences the reabsorption of sodium and excretion of potassium (from and into the tubular fluids, respectively) of the kidney, thereby indirectly influencing water retention or loss, blood pressure, and blood volume. When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and kidney disease. Aldosterone has exactly the opposite function of the atrial natriuretic hormone secreted by the heart.
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Trending Topic Today
Search Interest Perspective
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Aldosterone overload: An underappreciated contributor to high blood pressure - health.harvard.edu
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Aldosterone synthase inhibitors: a new option for antihypertensive, cardio-renal protection - Nature
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Dysregulated Aldosterone Production in Obesity Is Associated With Adverse Cardiac Structure, Function, and Adiposity - American Heart Association Journals
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Primary Aldosteronism - American Academy Of Family Physicians | AAFP
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Aldosterone synthase inhibitors for hypertension: A breakthrough facing barriers to adoption - PLOS
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Aldosterone: The Forgotten Hormone - Medscape
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Sex Hormones, Aldosterone, and Hypertension Risk in Women, With Erin Michos, MD - HCPLive
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Adrenal Aldosterone Synthase Expression Imaging in Primary Aldosteronism - NEJM
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Is Obesity a Major Driver of Primary Aldosteronism?: - JACC Journals
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Aldosterone synthase inhibitors for the treatment of cardiovascular disease - Nature
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Resistant Hypertension: A Genetic Window on Aldosterone, Potassium, and Missed Clinical Opportunities - American Heart Association Journals
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High Blood Pressure? Consider the Aldosterone Connection - Medscape
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Plasma aldosterone concentration and plasma renin activity in untreated hypertensive patients: gender differences and therapeutic implications - Nature
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Aldosterone and Impaired Nocturnal Blood Pressure Decline in Primary Aldosteronism - American Heart Association Journals
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Aldosterone excess, blood pressure control, and kidney outcomes in chronic kidney disease: findings from the Cardiovascular and Metabolic Disease Etiology Research Center-High Risk (CMERC-HI) Study - Nature
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Regulation of Aldosterone Secretion by Substance P and the Neurokinin Type 1 Receptor in Aldosterone‐Producing Adenomas - American Heart Association Journals
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Human 3D Cardiac Microtissue Model to Investigate Aldosterone-Induced Fibrosis and Electrical Dysfunction - American Heart Association Journals
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Aldosterone and the Mineralocorticoid Receptor in Atrial Fibrillation - American Heart Association Journals
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Rapid Nongenomic Effect of Aldosterone on Vasoconstriction - American Heart Association Journals
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Leptin and the Renin-Angiotensin-Aldosterone System - American Heart Association Journals
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Subtyping of Primary Aldosteronism in Partial Adrenal Vein Sampling: The Relative Aldosterone Secretion Index - American Heart Association Journals
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Leptin-Triggered Aldosterone and ECMR Activation as a Mechanistic Axis of Salt-Sensitive Hypertension in Young Female Mice - American Physiological Society Journal
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The role of sex hormones in aldosterone... : Cardiovascular Endocrinology & Metabolism - Ovid
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Beyond Spironolactone: Does Next Generation of Aldosterone Blockade Add Value? - American Heart Association Journals
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Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction - NEJM
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Aldosterone-renin ratio and plasma renin activity as biomarkers for treatment response in resistant hypertension - Nature
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Vascular Aldosterone in Genetically Hypertensive Rats - American Heart Association Journals
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Residual risk in cardiovascular and renal diseases and the potential role of aldosterone synthase inhibitors - Frontiers
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Renin-Angiotensin-Aldosterone System in Preeclampsia: Pathophysiological Insights and Links to Vascular Dementia - American Heart Association Journals
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Big Data Approach to Assessment of an Aldosterone-Renin Ratio for Detection of Potential Surgical Cases of Primary Aldosteronism - American Heart Association Journals
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Beyond Aldosterone: Rethinking Mineralocorticoid Receptor Antagonism in Heart Failure With Mildly Reduced and Preserved Ejection Fraction - JACC Journals
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Targeting Aldosterone at Its Source: The Arrival of Baxdrostat for Resistant Hypertension - Pharmacy Times
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FDA Approves Baxdrostat as First-in-Class Aldosterone Synthase Inhibitor for Hypertension - Pharmacy Times
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Direct aldosterone stimulation of skeletal muscle fibroblasts changes gene expression and differentially affects fibroblast functions from normal and diseased muscles - Frontiers
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Aldosterone–mineralocorticoid receptor interactions: new insights and therapeutic perspectives in primary aldosteronism - Nature
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Jon Congleton, Mineralys Therapeutics - Investment Reports
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Identification of Aldosterone-Producing Adrenal Adenomas Using [68Ga]Ga-Pentixafor PET/CT in an Australian Cohort - jnm.snmjournals.org
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Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC - Nature
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Journal of Internal Medicine - Wiley Online Library
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Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density-Dependent Mechanisms in Aldosterone-Producing Adenomas - Wiley & Sons
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Commensal microbiota regulate aldosterone - American Physiological Society Journal
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Elevated plasma aldosterone-to-renin ratio as a potential risk marker of adverse left ventricular remodeling: a cross-sectional study - Frontiers
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FDA approves first-in-class aldosterone synthase inhibitor for uncontrolled hypertension - European Pharmaceutical Review
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FDA Approves Baxdrostat as First Aldosterone Synthase Inhibitor for Hypertension - Drug Topics
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The Role of Aldosterone & Aldosterone Synthase Inhibitors in Cardiology, with Javed Butler, MD, MBA - HCPLive
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Baxdrostat and the future of aldosterone-targeted therapy - Nature
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Aldosterone-mediated hypertension and non-steroidal mineralocorticoid receptor antagonists - Nature
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Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation - American Heart Association Journals
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Baxdrostat New Drug Application accepted under FDA Priority Review in the US for patients with hard-to-control hypertension - AstraZeneca
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FDA approves first-in-class hypertension drug from AstraZeneca - Cardiovascular Business
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Plasma Aldosterone Measurement to Guide Prevention and Treatment of Heart Failure in Black Adults With Hypertension - JACC Journals
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BAXFENDY approved in the US as the first and only aldosterone synthase inhibitor treatment for adults with hypertension - Business Wire
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Identification of Aldosterone-Producing Adrenal Adenomas Using [68Ga]Ga-Pentixafor PET/CT in an Australian Cohort - jnm.snmjournals.org
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Different effect of aldosterone on corrected HCO3− across primary aldosteronism subtypes | Hypertension Research - Nature
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Aldosterone increases the expression and subcellular localization of SERCA2a and SERCA2b in the rat mesenteric artery - Frontiers
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Toward endotype-guided renin-angiotensin-aldosterone system modulation in septic shock - Springer Nature Link
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AstraZeneca’s Baxfendy becomes first aldosterone synthase inhibitor approved for hypertension in US - AllSci
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Primary Aldosteronism Management: Underrecognized but Evolving - endocrinologyadvisor.com
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Diagnostic value of 24-h urinary aldosterone and related biomarkers for screening primary aldosteronism in medication-exposed populations - Frontiers
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[Figure, Steroid Hormone Synthesis Pathways from...] - StatPearls - National Institutes of Health (NIH) | (.gov)
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Primary aldosteronism and obstructive sleep apnea in hypertension: interplay, target organ damage, and clinical management - Frontiers
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FW In Conversation: Mineralys' CEO Jon Congleton on reviving innovation in hypertension and positioning a potential best-in-class aldosterone synthase inhibitor - FirstWord Pharma
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Site of action for common antihypertensive drug classes targeting the Renin-Angiotensinogen-Aldosterone pathway. - PLOS
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Severe Hypokalemia and Life-Threatening Ventricular Arrhythmias: A Case of Normotensive Primary Aldosteronism - Cureus
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This Sneaky Hormone Could Be Raising Your Blood Pressure Right Now - Woman's World
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Peptide Deformylase Regulates Aldosterone Production Through Calbindin 1 - American Heart Association Journals
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Comparisons of renin-angiotensin-aldosterone levels measured by chemical luminescence immunoassay and liquid chromatography-tandem mass spectrometry in hypertensive patients under different pathophysiological conditions - Nature
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Plasma aldosterone is low in patients hospitalized with COVID-19 and not associated with changes in serum potassium levels: post-hoc observational analyses of clinical trial data - Frontiers
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Novel ASI Shows Promise for Uncontrolled Hypertension in CKD - Medscape
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InnovStone's SYH2072 Enters Phase I Trial - AllSci
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Baxfendy (Baxdrostat): Redefining... : Amrita Journal of Medicine - Ovid
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Renin-angiotensin-aldosterone system inhibitor... : Hepatology - Ovid
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Breakthrough or Band-Aid? New Drug for Primary Aldosteronism Sparks Debate - PR Newswire
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Diagnostic performance of 24-hour urinary aldosterone for primary aldosteronism in patients with or without discontinuation of antihypertensive medications - Nature
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Aldosterone Synthase Inhibition for Hypertension - NEJM
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Evaluating the role of aldosterone synthesis on adrenal cell fate - Frontiers
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Synergistic interplay between cortisol and aldosterone: unveiling mechanisms of vascular calcification in hyperaldosteronism | Hypertension Research - Nature
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Exploring aldosterone: Blood pressure and disease insights - AstraZeneca
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Mixed Aldosterone and Cortisol Secretion in Patients with Adrenal Incidentalomas: Different Faces of the Old Concept of Connshing Syndrome - Cureus
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The association between aldosterone and lipid profiles in patients with primary aldosteronism - Nature
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Effect of exercise training on the renin–angiotensin–aldosterone system: a meta–analysis - Nature
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Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19 - NEJM
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Aldosterone breakthrough as a clue to the physiological importance of paracrine regulation of aldosterone secretion - Nature
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Major trial indicates potential of novel hypertension drug - European Pharmaceutical Review
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Aldosterone and Treatment-Resistant Hypertension - NEJM
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Aging and Adrenal Aldosterone Production - American Heart Association Journals
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Aldosterone Production Is Activated in Failing Ventricle in Humans - American Heart Association Journals
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Sustained Reduction of Aldosterone in Response to the Angiotensin Receptor Blocker Valsartan in Patients With Chronic Heart Failure: - American Heart Association Journals
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Comparative analysis of aldosterone and renin assays for primary aldosteronism screening - Nature
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Aldosterone in the brain and cognition: knowns and unknowns - Frontiers
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Effect of sodium-glucose cotransporter-2 inhibitors on aldosterone and renin levels in diabetes mellitus type 2 patients: a systematic review and meta-analysis - Nature
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Drug Effects on Aldosterone/Plasma Renin Activity Ratio in Primary Aldosteronism | Hypertension - American Heart Association Journals
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Inhibition of aldosterone synthase: Does this offer advantages compared with the blockade of mineralocorticoid receptors? - Nature
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Efficacy and Safety of Aldosterone Synthase Inhibitors for Hypertension: A Meta-Analysis of Randomized Controlled Trials and Systematic Review - American Heart Association Journals
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Poor sleep quality was associated with increased plasma aldosterone concentration in community dwellers, a cross-sectional study - Nature
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Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production - Nature
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Synergistic prognostic effect of the renin-angiotensin-aldosterone system and immune-checkpoint inhibition in advanced lung cancer: The SPERICIL study - Wiley Online Library
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Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19 - NEJM
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Early Implementation of Aldosterone-Targeted Therapy in Patients With Hypertension - American Heart Association Journals
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BAXFENDY approved in the US as the first and only aldosterone synthase inhibitor treatment for adults with hypertension - bastillepost.com
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.