Why is "Aicardi–Goutières syndrome" trending?
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Trend Analysis
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- Date: 2026-03-24 05:21:20
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Aicardi–Goutières syndrome (AGS), which is completely distinct from the similarly named Aicardi syndrome, is a rare, usually early onset childhood, inflammatory disorder most typically affecting the brain and the skin. The majority of affected individuals experience significant intellectual and physical problems, although this is not always the case. The clinical features of AGS can mimic those of in utero acquired infection, and some characteristics of the condition also overlap with the autoimmune disease systemic lupus erythematosus (SLE). Following an original description of eight cases in 1984, the condition was first referred to as 'Aicardi–Goutières syndrome' (AGS) in 1992, and the first international meeting on AGS was held in Pavia, Italy, in 2001.
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Search Interest Perspective
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Aicardi-Goutières syndrome: Phenotypic and genetic spectrum in a series of three cases - Anales de Pediatría
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ATAD3 duplications bridge mitochondrial diseases and Aicardi–Goutières syndrome - Wiley Online Library
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ImmuneSensor Therapeutics Doses First Patient with Aicardi Goutières Syndrome (AGS) in Phase 1b Clinical Study of cGAS inhibitor, IMSB301 - Yahoo Finance
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Myasthenia Gravis as a Manifestation of Aicardi–Goutières Syndrome Due to a SAMHD1 Variant Successfully Treated With Baricitinib - Cureus
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The intersection of TREX1, cGAS, STING and the DNA damage theory of aging - Frontiers
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Seaford family fundraises for daughter and families with rare genetic disorders - News12 | Long Island
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Hangzhou Innogate Pharma discloses cGAS inhibitors - BioWorld MedTech
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Child Neurology: Aicardi-Goutières Syndrome Presenting as Recurrent Ischemic Stroke - Neurology® Journals
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Janus Kinase Inhibition in the Aicardi–Goutières Syndrome - New England Journal of Medicine
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DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes - rupress.org
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Children's Hospital of Philadelphia Researchers Find Some Patients with Aicardi Goutières Syndrome Have Normal IQ - PR Newswire
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Hydroxychloroquine modulates immunological pathways activated by RNA:DNA hybrids in Aicardi–Goutières syndrome patients carrying RNASEH2 mutations - Nature
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Case Report: Heterozygous ADAR c.3019G>A pathogenic variant associated with variable neurological symptoms and incomplete penetrance in a four-generational family - Frontiers
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Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome - New England Journal of Medicine
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Delayed Diagnosis of Aicardi-Goutières Syndrome in a 10-Year-Old Female Child With TREX1 Mutation: A Case Report - Cureus
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Neuromyelitis optica in a child with Aicardi-GoutiÈres syndrome - Neurology® Journals
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JAK Inhibition in the Aicardi–Goutières Syndrome - New England Journal of Medicine
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Janus Kinase Inhibition in the Aicardi–Goutières Syndrome - New England Journal of Medicine
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Case report: Pneumocystis jirovecii pneumonia in a severe case of Aicardi–Goutières syndrome with an IFIH1 gain-of-function mutation mimicking combined immunodeficiency - Frontiers
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Baricitinib Treatment in RNU7-1-Associated Aicardi–Goutières Syndrome in a South African Child: A Case Report - Wiley Online Library
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Neuroimaging in Aicardi-Goutières syndrome - Neurology® Journals
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Aicardi–Goutières syndrome and the type I interferonopathies - Nature
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Interleukin-6-induced neuroinflammation is exacerbated by subclinical levels of interferon-α - Frontiers
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Interstitial Lung Disease and Psoriasis in a Child With Aicardi-Goutières Syndrome - Frontiers
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Case Report: Aicardi-Goutières Syndrome Caused by Novel TREX1 Variants - Frontiers
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RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation - Nature
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Case Report: Novel Compound Heterozygous RNASEH2B Mutations Cause Aicardi–Goutières Syndrome - Frontiers
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JAK Inhibition in the Aicardi–Goutières Syndrome - New England Journal of Medicine
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Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature - Nature
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Tests show the cognitive abilities of children with a rare disorder. - National Center for Advancing Translational Sciences (NCATS) (.gov)
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Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study - thelancet.com
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Genetic Testing Contributes to Diagnosis in Cerebral Palsy: Aicardi-Goutières Syndrome as an Example - Frontiers
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Case Report: Generalised Panniculitis as a Post-COVID-19 Presentation in Aicardi-Goutières Syndrome Treated With Ruxolitinib - Frontiers
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The importance of chilblains as a diagnostic clue for mild Aicardi–Goutières syndrome - Wiley Online Library
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Dyschromatosis symmetrica hereditaria: A clue to early diagnosis of Aicardi–Goutières syndrome - Wiley Online Library
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Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus - Frontiers
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Novel Stem Cell-Derived Model Created of Inflammatory Neurological Disorder - UC San Diego Today
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Brain Pathology | ISN Neuropathology Journal - Wiley Online Library
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TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids | Molecular Psychiatry - Nature
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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response - Nature
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How viruses hijack part of your immune system and use it against you - Mayo Clinic News Network
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Astrocyte–Oligodendrocyte–Microglia Crosstalk in Astrocytopathies - Frontiers
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The type I interferonopathies: 10 years on - Nature
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Case report: Durable response to ruxolitinib in a child with TREX1 -related disorder - Frontiers
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Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection - Nature
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A large homozygous deletion in the SAMHD1 gene causes atypical Aicardi–Goutiéres syndrome associated with mtDNA deletions - Nature
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Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity - Science | AAAS
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Type I Interferonopathies in Children: An Overview - Frontiers
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CNS disease associated with enhanced type I interferon signalling - thelancet.com
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Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview - rupress.org
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Promising pathway discovered to treat rare childhood brain disease - The University of Sydney
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A central role for PI3K-AKT signaling pathway in linking SAMHD1 -deficiency to the type I interferon signature - Nature
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Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy - Frontiers
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Type I Interferons as Ambiguous Modulators of Chronic Inflammation in the Central Nervous System - Frontiers
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New therapy shows promise for a rare childhood dementia - The University of Sydney
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Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α - Frontiers
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Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus - Nature
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STING palmitoylation as a therapeutic target - Nature
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Sort Your Self Out! - ScienceDirect.com
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'It's terminal' | Georgia twin boys with autism now fighting rare genetic disorder after being infected by COVID - 11Alive.com
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Rome Therapeutics' 'dark genome' therapy shows early efficacy against autoimmune disease in mice - Fierce Biotech
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Updated roles of cGAS-STING signaling in autoimmune diseases - Frontiers
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Meet Archie, the Pāpāmoa 3-year-old in hospice care at home - NZ Herald
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Girl's birthday wish - to help children with rare genetic condition - SoMdNews.com
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After eight years of struggling to communicate, a new device has helped to unlock Ace’s world - NDIS
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Pediatria Polska - Polish Journal of Paediatrics - termedia.pl
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'To us it was priceless': Parents' joy as boy with rare neurological condition waves for Mother's Day - Australian Broadcasting Corporation
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Parents fundraise to extend life of brain-damaged son - BBC
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Re-discovering milestones through therapy - Herald Sun
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Fundraiser launched to buy vehicle - Daily Telegraph Sydney
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Family of sick children thank fundraisers for helping to smash target - thetelegraphandargus.co.uk
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TEZSPIRE Comprehensive Forecast on the Accelerating Market - openPR.com
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The boy who may never walk or talk - Daily Mail
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