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Wikipedia Overview
Biological risk assessment representation
An adverse outcome pathway (AOP) is structured representation of biological events leading to adverse effects and is considered relevant to risk assessment. The AOP links in a linear way existing knowledge along one or more series of causally connected key events (KE) between two points — a molecular initiating event (MIE) and an adverse outcome (AO) that occur at a level of biological organization relevant to risk assessment. The linkage between the events is described by key event relationships (KER) that describe the causal relationships between the key events.
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Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation - Frontiers
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Adverse Outcome Pathway on Deposition of Energy Leading to Cataracts - OECD
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Environmental and Molecular Mutagenesis | EMGS Journal - Wiley Online Library
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Adverse Outcome Pathway on Deposition of Energy Leading to Occurrence of Bone Loss - OECD
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Proof of concept for quantitative adverse outcome pathway modeling of chronic toxicity in repeated exposure - Nature
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Novel perspective on particulate matter and Alzheimer's disease: Insights from adverse outcome pathway framework - ScienceDirect.com
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Adverse Outcome Pathway on Deposition of Energy Leading to Learning and Memory Impairment - OECD
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Putative Adverse Outcome Pathway for Parkinson’s Disease-like Symptoms Induced by Silicon Quantum Dots based on In Vivo Vitro Approaches - ACS Publications
2024-08-26 07:00
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Adverse Outcome Pathway Framework Facilitates Use of Human Information to Increase Understanding of COVID-19 - Physicians Committee for Responsible Medicine
2021-02-22 08:00
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Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles - Frontiers
2024-06-29 04:30
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Environmental and Molecular Mutagenesis | EMGS Journal - Wiley Online Library
2024-09-04 07:00
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The 2021 update of the EPA’s adverse outcome pathway database - Scientific Data - Nature
2021-07-12 07:00
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Adverse Outcome Pathway on Deposition of Energy Leading to Abnormal Vascular Remodeling - OECD
2025-06-30 07:00
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Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity - Frontiers
2024-03-25 07:00
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Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development - OECD
2025-06-25 16:05
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Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross-Species Adverse Outcome Pathway Network for Reproductive Toxicity - Wiley Online Library
2024-07-09 07:00
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Development of a data-driven approach to Adverse Outcome Pathway network generation: a case study on the EATS-modalities - Frontiers
2023-05-08 07:00
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Adverse outcome pathway networks I: Development and applications - Wiley Online Library
2018-02-28 08:00
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Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment - Wiley Online Library
2019-05-25 07:00
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How the Pacific Oyster Responds to Ocean Acidification: Development and Application of a Meta-Analysis Based Adverse Outcome Pathway - Frontiers
2024-06-26 07:14
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JAK/STAT and TGF-ß activation as potential adverse outcome pathway of TiO - Nature
2017-12-19 08:00
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