Why is "Activin A" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-27 21:48:00
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Activin_A entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-27 and was most recently seen on 2026-03-27.
Wikipedia Overview
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely, inhibin downregulates FSH synthesis and inhibits FSH secretion. The existence of inhibin was hypothesized as early as 1916; however, it was not demonstrated to exist until Neena Schwartz and Cornelia Channing's work in the mid-1970s, after which both proteins were molecularly characterized ten years later.
Read more on Wikipedia →Related Topics
Trending Topic Today
Search Interest Perspective
-
Periodontitis induces skeletal muscle atrophy by increasing circulating levels of activin A. - Nature
-
Activin A–Endothelin-1 Axis Governs Pulmonary Vascular Remodeling: Mechanistic Basis for Emerging Therapies in PAH - American Heart Association Journals
-
Enabling large-scale iPSC-derived islet differentiation with GMP activin A and KGF - News-Medical
-
Elucidating the roles of microRNA-103a-3p in trophoblast invasion and SOX4-mediated extravillous differentiation induced by activin A - Nature
-
Activin A–Endothelin-1 Axis Governs Pulmonary Vascular Remodeling: Mechanistic Basis for Emerging Therapies in PAH - American Heart Association Journals
-
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight - PNAS
-
SLC7A11-AS1 contributes to prolonged activation of activin A/Smad signaling by suppressing PPM1A myristoylation in pancreatic cancer - Nature
-
ActivinA modulates B-acute lymphoblastic leukaemia cell communication and survival by inducing extracellular vesicles production - Nature
-
Stepwise release of Activin-A from its inhibitory prodomain is modulated by cysteines and requires furin coexpression to promote melanoma growth | Communications Biology - Nature
-
Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner - Nature
-
In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma - Nature
-
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature
-
Activin A is deeply involved in the progression of sarcopenia and leads to poor prognosis in lung cancer patients - Nature
-
Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling - Nature
-
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression - Nature
-
Follistatin-mediated vascular protection via inhibition of activin A in essential and secondary hypertension - Nature
-
Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation - Nature
-
Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction - Nature
-
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial - Nature
-
Structure and activation of pro-activin A - Nature
-
Increase in activin A may counteract decline in synaptic plasticity with age - Frontiers
-
Identification of Urinary Activin A as a Novel Biomarker Reflecting the Severity of Acute Kidney Injury - Nature
-
An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension - Nature
-
Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis - Nature
-
Elevated Levels of Activin A in Heart Failure: - American Heart Association Journals
-
Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis - Nature
-
GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates - Nature
-
glioblastoma cells contribute to resistance to anti-angiogenesis therapy through malformed vasculature - Nature
-
Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia - PNAS
-
Activin A more prominently regulates muscle mass in primates than does GDF8 - Nature
-
Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice - Science | AAAS
-
Activin A is increased in the nucleus accumbens following a cocaine binge - Nature
-
The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan - Nature
-
Activin A and Sertoli Cells: Key to Fetal Testis Steroidogenesis - Frontiers
-
Overcoming TGFβ and activin A suppression boosts NK cell antitumor function - Nature
-
Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma - Nature
-
Increased activin A levels in prediabetes and association with carotid intima-media thickness: a cross-sectional analysis from I-Lan Longitudinal Aging Study - Nature
-
Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells - Nature
-
Activin A Inhibits Differentiation of Chick Myogenic Cells In Vitro - BioOne Complete
-
Therapeutic blockade of activin-A improves NK cell function and antitumor immunity - Science | AAAS
-
Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling - Nature
-
Hepatic Activin A: An Exciting Target for Cardiometabolic Health - American Heart Association Journals
-
Hypoxia Exposure Promotes Th17 Cell Differentiation Through Activin A-PKM2 Axis to Exacerbate Autoimmune and Autoinflammatory Diseases - Wiley & Sons
-
Activin-A signaling promotes epithelial–mesenchymal transition, invasion, and metastatic growth of breast cancer - Nature
-
Activin A Secreted From Peripheral Nerve Fibroblasts Promotes Proliferation and Migration of Schwann Cells - Frontiers
-
Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure - Frontiers
-
Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer - Nature
-
Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells - Frontiers
-
Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A - PNAS
-
Hepatic Activin A: An Exciting Target for Cardiometabolic Health - American Heart Association Journals
-
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathways - PNAS
-
Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes - Nature
-
A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis - Nature
-
The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes - Frontiers
-
Activin Signaling in the Pathogenesis and Therapy of Neuropsychiatric Diseases - Frontiers
-
The yin and yang of Activin A - ScienceDirect.com
-
Activin E is a new guardian protecting against hepatic steatosis via inhibiting lipolysis in white adipose tissue - Nature
-
Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure - Nature
-
Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2 - Wiley Online Library
-
Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling - Nature
-
Reply to Sun et al.: Roles of adult Leydig cell-derived activin A remain to be determined - PNAS
-
Oncology Reports - Spandidos Publications
-
Lenalidomide in combination with an activin A-neutralizing antibody: preclinical rationale for a novel anti-myeloma strategy - Nature
-
The Expression of Human Cytomegalovirus MicroRNA MiR-UL148D during Latent Infection in Primary Myeloid Cells Inhibits Activin A-triggered Secretion of IL-6 - Nature
-
Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment - Nature
-
Experimental and Therapeutic Medicine - Spandidos Publications
-
Structural basis for the inhibition of activin signalling by follistatin - Springer Nature Link
-
Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva - Nature
-
Inhibin/activin expression in human and rodent liver: subunits α and βB as new players in human hepatocellular carcinoma? | British Journal of Cancer - Nature
-
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo–orchitis in mice - Nature
-
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension - Science | AAAS
-
Regulation of hepcidin expression by inflammation-induced activin B - Nature
-
Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells - Nature
-
Activin A-producing alveolar macrophage supports the progression of lung cell carcinoma (M Ishii G, in Nat Commun.) - ifrec.osaka-u.ac.jp
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.