Why is "Acrosome" trending?
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- Date: 2026-03-13 11:14:39
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Wikipedia Overview
The acrosome is an organelle that develops over the anterior (front) half of the head in the spermatozoa of humans and many other animals. It is a cap-like structure derived from the Golgi apparatus. In placental mammals, the acrosome contains degradative enzymes. These enzymes break down the outer membrane of the ovum, called the zona pellucida, allowing the haploid nucleus in the sperm cell to join with the haploid nucleus in the ovum.
This shedding of the acrosome, known as the acrosome reaction, can be stimulated in vitro by substances that a sperm cell may encounter naturally, such as progesterone or follicular fluid, as well as the more commonly used calcium ionophore A23187. This can be done to serve as a positive control when assessing the acrosome reaction of a sperm sample by flow cytometry or fluorescence microscopy. This is usually done after staining with a fluoresceinated lectin such as FITC-PNA, FITC-PSA, FITC-ConA, or fluoresceinated antibody such as FITC-CD46.
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Trending Topic Today
Search Interest Perspective
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Neprilysin 4 controls acrosome structure and male fertility in Drosophila melanogaster - Nature
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The intrinsically disordered protein SPE-56 is required for acrosomal-like exocytosis and fertility in Caenorhabditis elegans - Nature
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Journal of Cellular Physiology | Cell Biology Journal - Wiley Online Library
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Extraction, purification, biological effects and applications of acrosin: a review - Frontiers
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Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility - Science | AAAS
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Lack of acrosome formation in mice lacking a Golgi protein, GOPC - PNAS
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Immunolocalization and proteomic analyses of IZUMO1 in porcine spermatozoa - Frontiers
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Role of the Ubiquitin-Proteasome System in Mammalian Male Germ Cell Differentiation and Reproductive Fitness - Wiley Online Library
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Simultaneous removal of sperm plasma membrane and acrosome before intracytoplasmic sperm injection improves oocyte activation/embryonic development - PNAS
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From localization to function: comparative analysis of CB1 in sperm across species and its epigenetic role in humans - Nature
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Lack of Acrosome Formation in Hrb-Deficient Mice - Science | AAAS
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Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm - Frontiers
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Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse - PNAS
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Spermatozoa lacking TEX51 display hypofertility and defects in morphology | Communications Biology - Nature
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Membrane Remodeling and Matrix Dispersal Intermediates During Mammalian Acrosomal Exocytosis - Frontiers
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Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs - PNAS
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Bicarbonate buffer enhances functional sperm selection compared to Zwitterionic buffers in sperm preparation - Nature
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Characterization of expression patterns and dynamic relocation of Notch proteins during acrosome reaction of bull spermatozoa - Nature
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A comparison of sperm parameters DNA fragmentation and telomere length in testicular versus ejaculated spermatozoa - Nature
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Probing spermiogenesis: a digital strategy for mouse acrosome classification - Nature
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Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse - PNAS
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Pt-LIS1 participates nuclear deformation and acrosome formation via regulating Dynein-1 during spermatogenesis in Portunus trituberculatus - Nature
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Calcium-triggered acrosomal exocytosis in human spermatozoa requires the coordinated activation of Rab3A and N-ethylmaleimide-sensitive factor - PNAS
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AU040320 deficiency leads to disruption of acrosome biogenesis and infertility in homozygous mutant mice - Nature
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Beneficial effects of carvacrol loaded phytosomes on enhancing cryotolerance of Buffalo semen following cryopreservation - Nature
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Exogenous progesterone during in vitro fertilization improves developmental competence of partially cumulus-denuded bovine oocytes - ScienceDirect.com
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Human Zona Pellucida Glycoproteins: Binding Characteristics With Human Spermatozoa and Induction of Acrosome Reaction - Frontiers
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Globozoospermia and lack of acrosome formation in GM130-deficient mice - Nature
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Seeing is believing: Current methods to observe sperm acrosomal exocytosis in real time - Wiley Online Library
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The opioid peptide beta‐endorphin stimulates acrosome reaction in human spermatozoa - Wiley Online Library
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Atg7 is required for acrosome biogenesis during spermatogenesis in mice - Nature
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Lectin staining and flow cytometry reveals female-induced sperm acrosome reaction and surface carbohydrate reorganization - Nature
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Sperm immobilized before intracytoplasmic sperm injection undergo ultrastructural damage and acrosomal disruption - ScienceDirect.com
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channels contribute to the acrosomal pH-dependent intracellular Ca - Wiley
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No cap removal, no fertilization - EurekAlert!
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FER1L5 is indispensable for acrosome reaction and male fertility in mice - BioWorld News
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Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility - Nature
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Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility - Frontiers
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G protein-coupled estrogen receptor promotes acrosome reaction via regulation of Ca2 + signaling in mouse sperm† - BioOne Complete
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Proteomic analysis of sperm from fertile stallions and subfertile stallions due to impaired acrosomal exocytosis - Nature
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Sperm Nuclear Vacuoles in relation to Acrosome Reactions and Sperm Motility - Wiley Online Library
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Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest - Science | AAAS
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Bindin is essential for fertilization in the sea urchin - PNAS
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Recurrent Duplication and Diversification of Acrosomal Fertilization Proteins in Abalone - Frontiers
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Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion - Nature
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Modulation of spermatozoon acrosome reaction - SciELO Chile
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No cap removal, no fertilization - Asia Research News |
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Prolonged exposure of human spermatozoa in polyvinylpyrrolidone has detrimental effects on sperm biological characteristics - Wiley Online Library
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Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis - PNAS
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The Role of Sperm Morphology Standards in the Laboratory Assessment of Bull Fertility in Australia - Frontiers
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Effect of antioxidants on BPA-induced stress on sperm function in a mouse model - Nature
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Fertilization: a sperm’s journey to and interaction with the oocyte - jci.org
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Sperm competition enhances functional capacity of mammalian spermatozoa - PNAS
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Cryoprotectant-specific alterations in the proteome of Siberian sturgeon spermatozoa induced by cryopreservation - Nature
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Editorial: Sperm Differentiation and Spermatozoa Function: Mechanisms, Diagnostics, and Treatment - Frontiers
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A side-by-side comparison of different capacitation media in developing mouse sperm fertilizing ability - Nature
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Identification of hub genes and their expression profiling for predicting buffalo ( Bubalus bubalis ) semen quality and fertility - Nature
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Transformation of sperm structure in Octopus vulgaris: From spermatogenesis to spermatophoric release - PLOS
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Fatty acid composition and biophysical characteristics of the cell membrane of feline spermatozoa - Nature
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Deletion of ACTRT1 is associated with male infertility as sperm acrosomal ultrastructural defects and fertilization failure in human - Oxford Academic
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Novel sperm membrane protein facilitates mammalian fertilization - Phys.org
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Heat shock protein 70 kDa (HSP70) is involved in the maintenance of pig sperm function throughout liquid storage at 17 °C - Nature
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-ATPase (SERCA) is present in pig sperm and modulates their physiology over liquid preservation - Nature
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In vivo characterization of sAC null sperm - Frontiers
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Acrosin is essential for sperm penetration through the zona pellucida in hamsters - PNAS
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Epidermal growth factor alleviates the negative impact of urea on frozen-thawed bovine sperm, but the subsequent developmental competence is compromised - Nature
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RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling - Nature
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A Recurrent Deletion of DPY19L2 Causes Infertility in Man by Blocking Sperm Head Elongation and Acrosome Formation - ScienceDirect.com
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Complexity and modification of the bull sperm glycocalyx during epididymal maturation - Sečová - 2024 - Wiley
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Protective effect of rosiglitazone on microscopic and oxidative stress parameters of ram sperm after freeze-thawing - Nature
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Sperm preparedness and adaptation to osmotic and pH stressors relate to functional competence of sperm in Bos taurus - Nature
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Extramitochondrial cardiolipin suggests a novel function of mitochondria in spermatogenesis - Rockefeller University Press
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Porcine oviduct sperm binding glycoprotein and its deleterious effect on sperm: a mechanism for negative selection of sperm? - SciELO Chile
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Combined Raman and polarization sensitive holographic imaging for a multimodal label-free assessment of human sperm function - Nature
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Sperm physiology varies according to ultradian and infradian rhythms - Scientific Reports - Nature
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Reproductive Medicine and Biology | Reproduction Journal - Wiley Online Library
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Reconstruction of bovine spermatozoa substances distribution and morphological differences between Holstein and Korean native cattle using three-dimensional refractive index tomography - Nature
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Sperm lacking Bindin are infertile but are otherwise indistinguishable from wildtype sperm - Nature
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Proteomic analysis of fipronil-induced molecular defects in spermatozoa - Nature
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Temperature limits for storage of extended boar semen from the perspective of the sperm's energy status - Frontiers
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Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18 - Nature
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Effects of Cryopreservation on Gene Expression and Post Thaw Sperm Quality of Pacific Abalone, Haliotis discus hannai - Frontiers
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Reproductive Medicine and Biology | Reproduction Journal - Wiley Online Library
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The molecular chaperone cysteine string protein is required for monomeric SNARE proteins to assemble in trans -complexes during human sperm acrosomal exocytosis - BioOne Complete
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Seminal vesicle protein SVS2 is required for sperm survival in the uterus - PNAS
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Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation - Nature
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Mammalian spermatozoa and cumulus cells bind to a 3D model generated by recombinant zona pellucida protein-coated beads - Nature
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Zinc ion flux during mammalian sperm capacitation - Nature
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Human live spermatozoa morphology assessment using digital holographic microscopy - Nature
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Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility - Nature
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Stripped sperm may boost ICSI success rate - New Scientist
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Reproductive tract modifications of the boar sperm surface - Wiley Online Library
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Specific LED-based red light photo-stimulation procedures improve overall sperm function and reproductive performance of boar ejaculates - Nature
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Aspectos Morfológicos de Células de la Espermatogénesis en Diferentes Etapas de Maduración Sexual del Ratón Negro Isogénico C57BL/6/Uni - SciELO Chile
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Omega-3s Vital for Sperm Health - Live Science
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Molecular Basis of Human Sperm Capacitation - Frontiers
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Rat sperm immobilisation effects of a protein from Ricinus communis (Linn.): an in vitro comparative study with nonoxynol‐9 - Nithya - 2012 - Andrologia - Wiley Online Library
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Ultrastructural Morphology of Sperm from Human Globozoospermia - Ricci - 2015 - BioMed Research International - Wiley Online Library
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Training a computer to assess sperm quality - Scienza in rete
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Fertilization of a Human Egg Cell by a Sperm - doccheck.com
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