Why is "APOBEC3A" trending?

Search Interest Perspective

• APOBEC3 promotes squamous differentiation via IL-1A/AP-1 signaling - Nature
• Engineered deaminases enable precise RNA base editing - CRISPR Medicine News
• Therapy-induced APOBEC3A drives evolution of persistent cancer cells - Nature
• News: CMN Weekly (5 December 2025) - Your Weekly CRISPR Medicine News - CRISPR Medicine News
• Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes - Nature
• Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations - Nature
• Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways - Nature
• Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots - Nature
• Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A - Nature
• An extended APOBEC3A mutation signature in cancer - Nature
• RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization - Nature
• Engineering APOBEC3A deaminase for highly accurate and efficient base editing - Nature
• Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity - Nature
• APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis - Nature
• APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages - Nature
• APOBEC3A drives STING-dependent metastasis - Nature
• Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions - Nature
• Impact of the APOBEC3A/B deletion polymorphism on risk of ovarian cancer - Nature
• An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities - Nature
• Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B - Nature
• Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression - ASM Journals
• Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion - Nature
• NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity - Nature
• Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis - Nature
• APOBEC3A drives resistance - Nature
• APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers - Nature
• A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage - Nature
• An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers - Nature
• Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A - Nature
• Mechanisms of APOBEC3 mutagenesis in human cancer cells - Nature
• The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS - Nature
• APOBEC3A Protein May Be Linked to Drug Resistance in Patients With NSCLC - The ASCO Post
• Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients - Nature
• APOBEC3 mutagenesis drives therapy resistance in breast cancer - Nature
• Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression - ASM Journals
• SKI Study Sheds Light on How a Natural Defense Against Viruses Can Lead to Mutations in Cancer Cells - Memorial Sloan Kettering Cancer Center
• Efficient and precise base editing in rabbits using human APOBEC3A-nCas9 fusions - Nature
• APOBEC affects tumor evolution and age at onset of lung cancer in smokers - Nature
• Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features - Science | AAAS
• APOBEC3A Functions as a Restriction Factor of Human Papillomavirus - ASM Journals
• Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer - Nature
• The implications of APOBEC3-mediated C-to-U RNA editing for human disease - Nature
• Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA - Nature
• Army liposome formulation containing QS-21 render human monocyte-derived macrophages less permissive to HIV-1 infection by upregulating APOBEC3A - Nature
• Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity - Nature
• Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes - Nature
• Evaluation of APOBEC3 expression as prognostic marker in squamous cell carcinoma of the penis - Nature
• IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection - Nature
• APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer - Nature
• Enzyme linked to most prevalent mutational signatures in cancer cell lines - Medical Xpress
• The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness - Nature
• The curious case of APOBEC3 activation by cancer-associated human papillomaviruses - PLOS
• Deamination-independent restriction of LINE-1 retrotransposition by APOBEC3H - Nature
• Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry - Nature
• APOBEC3-mediated restriction of RNA virus replication - Nature
• Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance - Nature
• A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes - Nature
• Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects - Science | AAAS
• Hideko Isozaki Received IASLC 2025 Early Career Grant - Oncodaily