Why is "ALOXE3" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-03-19 07:46:33
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Epidermis-type lipoxygenase 3 is a member of the lipoxygenase family of enzymes; in humans, it is encoded by the ALOXE3 gene. This gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOX12B and ALOX15B. Among the human lipoxygenases, ALOXE3 is most closely related in amino acid sequence to ALOX12B. ALOXE3, ALOX12B, and ALOX15B are often classified as epidermal lipoxygenases, in distinction to the other three human lipoxygenases, because they were initially defined as being highly or even exclusively expressed and functioning in skin. The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases with mouse Aloxe3 being the ortholog to human ALOXE3, mouse Alox12b being the ortholog to human ALOX12B, and mouse Alox8 being the ortholog to human ALOX15B [supplied by OMIM]. ALOX12B and ALOXE3 in humans, Alox12b and Aloxe3 in mice, and comparable orthologs in other in other species are proposed to act sequentially in a multistep metabolic pathway that forms products that are structurally critical for creating and maintaining the skin's water barrier function.
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Search Interest Perspective
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The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase - PNAS
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miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities - Nature
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Natural sugar cuts diabetes risk in mice - futurity.org
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Identification and Validation of a Prognostic Signature for Prostate Cancer Based on Ferroptosis-Related Genes - Frontiers
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Natural Sugar Could Curb Diabetes - Genetic Engineering and Biotechnology News
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Massively parallel characterization of insulator activity across the genome - Nature
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Implication of a new function of human tDNAs in chromatin organization - Nature
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Ferroptosis and the bidirectional regulatory factor p53 - Nature
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TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis - Nature
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