Why is "ALDH" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-25 12:17:27
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
ALDH entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-25 and was most recently seen on 2026-04-25.
Wikipedia Overview
Aldehyde dehydrogenases are a group of enzymes that catalyse the oxidation of aldehydes. They convert aldehydes to carboxylic acids. The oxygen comes from a water molecule. To date, nineteen ALDH genes have been identified within the human genome. These genes participate in a wide variety of biological processes including the detoxification of exogenously and endogenously generated aldehydes.
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Trending Topic Today
Search Interest Perspective
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NIH Combines Traditional High-Throughput Screening and Artificial Intelligence to Fast-Track Probe Discovery for ALDH Enzymes - National Center for Advancing Translational Sciences (.gov)
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Engineered aldehyde dehydrogenases for amide bond formation - Science | AAAS
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ALDH2 protects against dopaminergic neuronal cell ferroptosis by enhancing the enzyme activity of PRDX6 in Parkinson’s disease - Nature
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cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression - Wiley & Sons
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An orally delivered bacteria‐based coacervate antidote for alcohol detoxification - ScienceDirect.com
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Transcriptome analysis and prognosis of ALDH isoforms in human cancer - Nature
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Targeting ALDH2 to promote skeletal muscle health: A novel strategy against mitochondrial dysfunction - Wiley & Sons
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cancer stem cells, EMT-MET, and glucose metabolism in breast cancer - Nature
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ATP-binding Cassette Transporters Substantially Reduce Estimates of ALDH-positive Cancer Cells based on Aldefluor and AldeRed588 Assays - Nature
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stem cells in triple negative breast cancer - Nature
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Genome-wide characterization of ALDH Superfamily in Brassica rapa and enhancement of stress tolerance in heterologous hosts by BrALDH7B2 expression - Nature
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The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension - Nature
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Self-assembled aldehyde dehydrogenase-activatable nano-prodrug for cancer stem cell-enriched tumor detection and treatment - Nature
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Aldehyde Dehydrogenases Function in the Homeostasis of Pyridine Nucleotides in Arabidopsis thaliana - Nature
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p53 functional states are associated with distinct aldehyde dehydrogenase transcriptomic signatures - Nature
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Association of alcohol dehydrogenase and aldehyde dehydrogenase Polymorphism with Spontaneous Deep Intracerebral Haemorrhage in the Taiwan population | Scientific Reports - Nature
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A novel bifunctional aldehyde/alcohol dehydrogenase catalyzing reduction of acetyl-CoA to ethanol at temperatures up to 95 °C - Nature
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Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer - Nature
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Aldehyde-alcohol dehydrogenase undergoes structural transition to form extended spirosomes for substrate channeling - Nature
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A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells - Nature
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Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells - Nature
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A red-shifted fluorescent substrate for aldehyde dehydrogenase - Nature
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Genome-wide identification, evolution, and transcript profiling of Aldehyde dehydrogenase superfamily in potato during development stages and stress conditions - Nature
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Structural insights into the production of 3-hydroxypropionic acid by aldehyde dehydrogenase from Azospirillum brasilense - Nature
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Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3 - Nature
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ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma - Nature
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Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins - Nature
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Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists - Nature
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Antarctic aldehyde dehydrogenase from Flavobacterium PL002 as a potent catalyst for acetaldehyde determination in wine - Nature
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Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1α-mediated biogenesis in acute kidney injury - Nature
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Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease - PNAS
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RNA-sequencing predicts a role of androgen receptor and aldehyde dehydrogenase 1A1 in osteosarcoma lung metastases | Oncogene - Nature
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Stanford-developed molecule homes in on enzyme that promotes colon cancer tumor growth - Stanford Medicine
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Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure - Nature
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A bacterial aromatic aldehyde dehydrogenase critical for the efficient catabolism of syringaldehyde - Nature
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Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice - Nature
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Targeting aldehyde dehydrogenase ALDH3A1 increases ferroptosis vulnerability in squamous cancer | Oncogene - Nature
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Filamentation of the bacterial bi-functional alcohol/aldehyde dehydrogenase AdhE is essential for substrate channeling and enzymatic regulation - Nature
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ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway - Nature
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Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells - PNAS
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cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation - Nature
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Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation - Nature
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Inhibition of human alcohol and aldehyde dehydrogenases by aspirin and salicylate: Assessment of the effects on first-pass metabolism of ethanol - ScienceDirect.com
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Expression of ALDH1 isotypes and its potential as a prognostic and diagnostic marker in patients with muscle invasive bladder cancer - Nature
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PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling | Cell Death & Disease - Nature
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Why Is There No Pill For ‘Asian Glow’? - Popular Science
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Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity - Nature
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Role for Mitochondrial Aldehyde Dehydrogenase? - JACC Journals
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Effect of alcohol and aldehyde dehydrogenase gene polymorphisms on alcohol-associated hypertension: the Guangzhou Biobank Cohort Study - Nature
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Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis | British Journal of Cancer - Nature
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Science Indicates That Sprite Might Be A Great Hangover Cure - Popular Science
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Acetaldehyde dehydrogenases in liver zonation and liver cancer - Medical Xpress
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Chemoresistance in ovarian cancer improved by combination therapy - Oncology Central
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ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis - Nature
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Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson’s disease - Nature
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Acetaldehyde dehydrogenases in liver zonation and liver cancer - EurekAlert!
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Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis - Nature
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Characterization of human oxidoreductases involved in aldehyde odorant metabolism - Nature
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Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells - PLOS
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PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling - Nature
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Hangover relief? L. mesenteroides probiotic shown to lower acetaldehyde levels - NutraIngredients.com
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Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation - Nature
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Why do hangovers seem so much worse as we get older? - NBC News
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A pear, lime and coconut water smoothie could be the 'ultimate hangover cure' - Yahoo Life UK
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Is Sprite the cure for your hangover woes? - CBS News
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Red wine has 'both cancerous and anti-cancerous properties' - Medical News Today
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Calcium Channels and Oxidative Stress Mediate a Synergistic Disruption of Tight Junctions by Ethanol and Acetaldehyde in Caco-2 Cell Monolayers - Nature
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Searching for a hangover cure - Chemistry World
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A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase - Nature
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Death by Durian Fruit? - Smithsonian Magazine
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Is Sprite the Best Hangover Remedy? - CSP Daily News
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‘Sprite’ and soda water best cures against hangover - ZME Science
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Sprite may be the best hangover remedy, scientists find - New York Daily News
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Hangover or alcohol intolerance? How to tell the difference - BBC
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Dealing with that new year hangover - thepost.co.nz
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Cure for hangover? Lemon & lime drink is the best at helping the body process alcohol - Study - YNaija
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.