Why is "ACTA2" trending?

Search Interest Perspective

• Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice - Nature
• Genomic Editing of a Pathogenic Sequence Variant in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice | Circulation - American Heart Association Journals
• Dysregulated smooth muscle cell proliferation and gene expression underlie ACTA2 variant-associated aortopathy - medRxiv
• Gene editing treats smooth muscle disease in preclinical model : Newsroom - UT Southwestern Medical Center
• Precision gene editing breakthrough for rare vascular disease - RegMedNet
• smooth muscle cells cause moyamoya-like cerebrovascular lesions in mice prevented by boosting OXPHOS - Nature
• Teaching NeuroImage: “Broomstick-Like” Appearance of Intracranial Arteries in ACTA2 Leukovasculopathy - Neurology® Journals
• Custom gene editor fixes mutation causing deadly ultrarare vascular disease in mice - Fierce Biotech
• Customized gene-editing technology shows potential to treat lethal pediatric disease - Medical Xpress
• Case report: Multisystemic smooth muscle dysfunction syndrome: a rare genetic cause of infantile interstitial lung disease - Frontiers
• Poland saved Europe from ACTA: can they save us from ACTA2? - Electronic Frontier Foundation
• Characteristic Cerebrovascular Findings Associated with ACTA2 Gene Mutations - Cambridge University Press & Assessment
• Stable Leukoencephalopathy in a Patient With ACTA2-Associated Multisystem Smooth Muscle Disorder - Neurology® Journals
• Identification of ACTA2 as a Key Contributor to Venous Malformation - Frontiers
• Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model - Nature
• How a genetic mutation can cause individuals with normal cholesterol to develop heart disease at a young age - Medical Xpress
• Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development - Nature
• A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms - Nature
• Three novel mutations in the ACTA2 gene in German patients with thoracic aortic aneurysms and dissections - Nature
• Case Report - Baishideng Publishing Group
• Multimodal optical imaging of iris flocculi in three consecutive generations: a case report - Frontiers
• Origin of CAFs in colorectal cancer - Nature
• Combined Surgical-Endovascular Treatment of an Intracranial Aneurysm in a Patient with ACTA2 Mutation - Cleveland Clinic
• Researchers Uncover Why a Gene Mutant Causes Young Children to Have Strokes - dicardiology.com
• Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells - Nature
• Iris Flocculi Are an Ocular Marker of Smooth Muscle -Actin (Acta2) Mutation in Familial Thoracic Aortic Aneurysms Leading to Acute Aortic Dissections (TAAD) | IOVS | ARVO Journals - ARVO Journals
• Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin - PNAS
• A panel of emerging EMT genes identified in malignant mesothelioma - Nature
• Myofibroblasts contribute to but are not necessary for wound contraction | Laboratory Investigation - Nature
• Promoters to Study Vascular Smooth Muscle | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
• Researchers uncover why a gene mutant causes young children to have strokes - Medical Xpress
• Network of medical detectives solve genomic mystery - Harvard Gazette
• Simple gene signature to assess murine fibroblast polarization - Nature
• Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition - Nature
• Clinical history and management recommendations of the smooth muscle dysfunction syndrome due to ACTA2 arginine 179 alterations - Nature
• Tracing a rare smooth muscle disorder to a single mutation in a non-coding gene - Medical Xpress
• LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation - Nature
• Genetic variants promoting smooth muscle cell proliferation can result in diffuse and diverse vascular diseases: Evidence for a hyperplastic vasculomyopathy - Nature
• Life-threatening gene defect located by UT-Houston researchers - EurekAlert!
• Phenotypic expansion of visceral myopathy associated with ACTG2 tandem base substitution - Nature
• Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation - Rockefeller University Press