Why is "ABCG2" trending?

Search Interest Perspective

• Role of the ABCG2 transporter in the biodistribution of the food-borne uremic toxin p -cresyl sulfate - Nature
• Synergistic effects of ABCG2 Q141K variant in combination with alcohol consumption and male sex on gout risk in a rare-event Taiwanese cohort - Nature
• Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications - Frontiers
• Integrative machine learning and molecular docking reveal Narirutin targets ABCC1/ABCG2 for immune microenvironment remodeling in colorectal cancer | Scientific Reports - Nature
• FBP1 promotes ABCG2-mediated uric acid excretion through activation of the PI3K/AKT/CREB signaling pathway - Nature
• Identification of novel drug-specific PARP inhibitor resistance mechanisms in ovarian cancer–implications for clinical practice - Nature
• The net electrostatic potential and hydration of ABCG2 affect substrate transport - Nature
• Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria - Nature
• Effect of genetic polymorphism of rosuvastatin transporter gene rs2231137 on its clinical efficacy and safety - Nature
• ABCG2 transports anticancer drugs via a closed-to-open switch - Nature
• Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism - Nature
• Structure of the human multidrug transporter ABCG2 - Nature
• The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion - Nature
• The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid - Nature
• The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells - Nature
• Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression - Nature
• The FOXP1-ABCG2 axis promotes the proliferation of cancer stem cells and induces chemoresistance in pancreatic cancer | Cancer Gene Therapy - Nature
• Evaluation of ABCG2-mediated extra-renal urate excretion in hemodialysis patients | Scientific Reports - Nature
• The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion - Nature
• Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states - Nature
• ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study - Nature
• The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria - Science | AAAS
• Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies - Nature
• Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior - Nature
• Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue - Nature
• E2F1 drives chemotherapeutic drug resistance via ABCG2 - Nature
• ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells - Nature
• Analysis of ABCG2 gene rs2231142 single nucleotide polymorphism and risk factors in hyperuricemia - Nature
• Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes - Nature
• Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors - Nature
• ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload - Nature
• Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation - Nature
• Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro in vivo and ex vivo - Nature
• Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2 - Nature
• Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier - Nature
• Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2 - Nature
• Common dysfunctional variants in ABCG2 are a major cause of early-onset gout - Nature
• Sleeve gastrectomy ameliorates renal injury in obesity-combined hyperuricemic nephropathy mice by modulating the AMPK/Nrf2/ABCG2 pathway - Nature
• RETRACTED ARTICLE: hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations - Nature
• Additive composite ABCG2 SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk - Nature
• ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics - Nature
• Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity | British Journal of Cancer - Nature
• Molecular Imaging of ABCB1 and ABCG2 Inhibition at the Human Blood–Brain Barrier Using Elacridar and - Journal of Nuclear Medicine
• ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ1–40 Peptides - Journal of Neuroscience
• A comprehensive analysis of the association of common variants of ABCG2 with gout - Nature
• Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) - Nature
• Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate | European Journal of Human Genetics - Nature
• Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging - Frontiers
• Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epithelium - Nature
• Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma - Nature
• Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells - Nature
• ABCG2 transporter inhibitor restores the sensitivity of triple negative breast cancer cells to aminolevulinic acid-mediated photodynamic therapy - Nature
• Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2- b ]indoles - Nature
• The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype - Nature
• Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters - Nature
• Cryogenic-electron microscopy (Cryo-EM) structures of a human ABCG2 mutant transporter protein - Phys.org
• Expression and functional characterization of ABCG2 in brain endothelial cells and vessels - Zhang - 2003 - Wiley & Sons
• Decreased extra-renal urate excretion is a common cause of hyperuricemia - Nature
• A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite - Nature
• SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2 - Nature
• Flow cytometry–based approach to ABCG2 function suggests that the transporter differentially handles the influx and efflux of drugs - Wiley Online Library
• Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines - PLOS
• The expression of ABC transporters and activation of JNK/c-jun in parental and multidrug resistant cells. A. - PLOS
• The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk - Nature
• Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant - Nature
• The predictive value of ABCB1 ABCG2 CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions - Nature
• Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development - Nature
• ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma - Nature
• Ponatinib is not transported by ABCB1, ABCG2 or OCT-1 in CML cells - Nature
• Identification of SP phenotype in bladder cancer cell lines. - PLOS
• Impact of ABCB1 ABCC1 ABCC2 , and ABCG2 variants in predicting prognosis and clinical outcomes of north Indian lung cancer patients undergoing platinum-based doublet chemotherapy - Wiley Online Library
• ABC Transporters and the Alzheimer’s Disease Enigma - Frontiers
• Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia - Frontiers
• Interactions of retinoids with the ABC transporters P-glycoprotein and Breast Cancer Resistance Protein - Nature
• Significance of nuclear EGFR and ABCG2 expression in malignant transformation of oral potentially malignant disorders - Wiley Online Library
• 抗体薬物複合体の耐性メカニズムを解明 - 金沢大学
• Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia: discordance between expression and function - Nature
• Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis - Nature
• Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells - Nature
• Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions - Nature
• NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout - Nature
• In Silico Targeting Human Multidrug Transporter ABCG2 in Breast Cancer: Database Screening, Molecular Docking, and Molecular Dynamics Study - Wiley Online Library
• Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects - Nature
• Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors - Nature
• Efflux transporters in ulcerative colitis: Decreased expression of BCRP (ABCG2) and Pgp (ABCB1) - Wiley Online Library
• Hh pathway activity in EGFR-TKI-sensitive and -resistant cells. - PLOS
• Bioluminescent imaging of drug efflux at the blood–brain barrier mediated by the transporter ABCG2 - PNAS
• New treatment prevents light-induced skin damage in EPP mice - Porphyria News
• Scientists Identify Blood Vessel Repair Cells - WCM Newsroom
• Johns Hopkins scientists out a gene for gout - EurekAlert!
• The genetics of early-onset gout - u-tokyo.ac.jp
• Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2 - Nature
• Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein - Nature
• Strategies for overcoming ABC transporter-mediated multidrug resistance in colorectal cancer - American Physiological Society Journal
• Transporter Pharmacogenetics and Statin Toxicity - Niemi - 2010 - ascpt.onlinelibrary.wiley.com
• Apatinib (YN968D1) enhances the efficacy of conventional chemotherapeutical drugs in side population cells and ABCB1-overexpressing leukemia cells - ScienceDirect.com