Why is "ABCA1" trending?

Search Interest Perspective

• Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells - Science | AAAS
• FLRT2 promotes foam cell formation and atherosclerosis by inhibiting USP22-mediated ABCA1 deubiquitination - Nature
• ABCA1-Mediated Structural Diversity of HDL Subspecies and Their Proposed Roles in Cardioprotection - American Heart Association Journals
• Common Genetic Variation in ABCA1 Is Associated With Altered Lipoprotein Levels and a Modified Risk for Coronary Artery Disease - American Heart Association Journals
• Advanced glycation end products drive blood-brain barrier lipid dysregulation via RAGE-ABCA1 signaling to promote neurovascular dysfunction in Alzheimer’s disease - Nature
• Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux - Nature
• Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy - Science | AAAS
• Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux - Nature
• Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs - American Heart Association Journals
• UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation - Nature
• SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis - American Heart Association Journals
• Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease - Nature
• HDL Apolipoproteins and ABCA1: - American Heart Association Journals
• Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease - Nature
• ABCA1 and Inflammation: - American Heart Association Journals
• Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux - Nature
• E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice - American Heart Association Journals
• Saffron as a natural modulator of reverse cholesterol transport genes in atherosclerotic rabbits, with molecular docking insights - Nature
• Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis - Nature
• Specific Loss of ABCA1 (ATP-Binding Cassette Transporter A1) Suppresses TCR (T-Cell Receptor) Signaling and Provides Protection Against Atherosclerosis - American Heart Association Journals
• CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice - Nature
• PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly - American Heart Association Journals
• Elucidating the Structural Features of ABCA1 in its Heterogeneous Membrane Environment - Frontiers
• New insights into cholesterol efflux via ABCA1 - Nature
• PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux - Journal of Neuroscience
• Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1 - Nature
• Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux - Nature
• Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels - Nature
• Expression analysis of ABCA1 in type 2 diabetic Pakistani patients with and without dyslipidemia and correlation with glycemic index and lipid profile - Nature
• Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor - American Heart Association Journals
• LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1 - Nature
• ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes - Journal of Neuroscience
• ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes - Journal of Neuroscience
• Cholesterol accumulation promotes ABCA1 degradation in astrocytes via Caveolin-1 mediated endocytosis in ApoE4 - Wiley & Sons
• Tissue Specific Role of ABCA1 in Lung Cholesterol Homeostasis under High-Cholesterol Diet - Frontiers
• ABCA1 dimer–monomer interconversion during HDL generation revealed by single-molecule imaging - PNAS
• Difference in expression patterns of placental cholesterol transporters, ABCA1 and SR-BI, in Meishan and Yorkshire pigs with different placental efficiency - Nature
• Regulation of the cholesterol efflux transporters ABCA1/ABCG1 in retina in hemochromatosis and by the endogenous iron chelator 2,5-dihydroxybenzoic acid | IOVS | ARVO Journals - iovs.arvojournals.org
• TNFα induces ABCA1 through NF-κB in macrophages and in phagocytes ingesting apoptotic cells - PNAS
• Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients - Frontiers
• Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function - Journal of Neuroscience
• V-ATPase (Vacuolar ATPase) Activity Required for ABCA1 (ATP-Binding Cassette Protein A1)-Mediated Cholesterol Efflux - American Heart Association Journals
• Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma - Nature
• Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles - American Heart Association Journals
• CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma - Nature
• MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels - Nature
• Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses - American Heart Association Journals
• Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1–SREBP pathway - Nature
• An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis - Nature
• Impact of Hepatic ABCA1 (ATP-Binding Cassette Transporter A1) Deletion on Reverse Cholesterol Transport A New Clue in Solving Complex HDL (High-Density Lipoprotein) Metabolism - American Heart Association Journals
• Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation - Nature
• Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells - American Heart Association Journals
• Maternal ABCA1 genotype is associated with severity of Smith–Lemli–Opitz syndrome and with viability of patients homozygous for null mutations - Nature
• Correction: Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma - Nature
• Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice - Journal of Neuroscience
• Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma - Nature
• How is good cholesterol made? - Asia Research News |
• Minimal Lipidation of Pre-β HDL by ABCA1 Results in Reduced Ability to Interact with ABCA1 - American Heart Association Journals
• High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages - Nature
• ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation - Nature
• Deletion of miR-33, a regulator of the ABCA1–APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice - Wiley & Sons
• High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells - Nature
• Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses - American Heart Association Journals
• Relative Contributions of ABCA1 and SR-BI to Cholesterol Efflux to Serum From Fibroblasts and Macrophages - American Heart Association Journals
• miR-33 links SREBP-2 induction to repression of sterol transporters - PNAS
• Common variants near ABCA1 AFAP1 and GMDS confer risk of primary open-angle glaucoma - Nature
• Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis - Nature
• A New Small Molecule Increases Cholesterol Efflux - American Heart Association Journals
• PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway - Nature
• The effect of ABCA1 gene DNA methylation on blood pressure levels in a Chinese hyperlipidemic population - Nature
• Adipocyte Membrane Cholesterol Regulates Obesity - American Heart Association Journals
• Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα - PNAS
• Tetrandrine ameliorated atherosclerosis in vitamin D3/high cholesterol diet-challenged rats via modulation of miR-34a and Wnt5a/Ror2/ABCA1/NF-kB trajectory - Nature
• A new role for lncRNAs in atherosclerosis - Nature
• Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein) - American Heart Association Journals
• Changes in the asymmetric distribution of cholesterol in the plasma membrane influence streptolysin O pore formation - Nature
• Dickkopf‐1 promotes vascular smooth muscle cell foam cell formation and atherosclerosis development through CYP4A11/SREBP2/ABCA1 - Wiley & Sons
• Small GTPase ARF6 Regulates Endocytic Pathway Leading to Degradation of ATP-Binding Cassette Transporter A1 - American Heart Association Journals
• Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis - Wiley Online Library
• Integration of methylation quantitative trait loci (mQTL) on dietary intake on DNA methylation levels: an example of n-3 PUFA and ABCA1 gene - Nature
• Genetic Variation in ABCA1 Predicts Ischemic Heart Disease in the General Population - American Heart Association Journals
• USC-led study finds potential new drug target for Alzheimer’s disease - Keck School of Medicine of USC
• The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells - Nature
• ATP-Binding Cassette Transporter A1 in Lipoprotein Metabolism and Atherosclerosis: - American Heart Association Journals
• Elder ( Sambucus nigra ), identified by high-content screening, counteracts foam cell formation without promoting hepatic lipogenesis - Nature
• T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice - Nature
• β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment - Nature
• ABC Transporters and the Alzheimer’s Disease Enigma - Frontiers
• Macrophage ATP-Binding Cassette Transporter A1 Overexpression Inhibits Atherosclerotic Lesion Progression in Low-Density Lipoprotein Receptor Knockout Mice - American Heart Association Journals
• The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport - PNAS
• With No Treatment for Tangier Disease, Management Focuses on Preventing Atherosclerosis - The American Journal of Managed Care
• Panax notoginseng saponins decrease cholesterol ester via up-regulating ATP-binding cassette transporter A1 in foam cells - ScienceDirect.com
• Clemson researchers tackle atherosclerosis – the ‘silent killer’ - Clemson News
• Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL - Nature
• Coronary artery disease, its associations with ocular, genetic and blood lipid parameters - Nature
• ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages - Wiley & Sons
• microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain - Journal of Neuroscience
• Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres: - American Heart Association Journals
• MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo - PNAS
• Mendelian randomization reveals probucol’s preventive role in Behçet’s disease via circulating metabolites - Nature