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Why is "5-MTHF" trending?

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Trend Analysis

  • Ranking position: #
  • Date: 2026-04-25 02:15:49

This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.

Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.

Trend Insight

5-MTHF entered the ranking for the first time today at position #. This is its highest position ever recorded.

Trend History

This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-25 and was most recently seen on 2026-04-25.

5-MTHF

Wikipedia Overview

Levomefolic acid (INN, also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood–brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon unit for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase (DHFR) to become biologically active. Systematic reviews suggest that adjunctive L-methylfolate modestly improves symptoms in major depressive disorder.

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Search Interest Perspective

Why This Topic Is Trending

This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.

Search Interest & Related Topics

Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.

Search Interest (Past 12 Months)

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