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A serotonin 5-HT2A receptor agonist, or simply 5-HT2A agonist, is a drug which acts as an agonist of the serotonin 5-HT2A receptor. The serotonin 5-HT2A receptor is one of 13 known human serotonin receptors. Serotonin 5-HT2A receptor agonists can be divided into two main groups: (1) serotonergic psychedelics such as LSD, psilocybin, and mescaline; and (2) non-hallucinogenic serotonin 5-HT2A receptor agonists such as lisuride, Ariadne, tabernanthalog, and zalsupindole, among others. Psychedelic and non-hallucinogenic serotonin 5-HT2A receptor agonists can be reliably distinguished from each other in scientific research using the head-twitch response assay in animals.
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