Why is "4C-TFM" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-08-19 06:45:43
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
4C-TFM entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-19 and was most recently seen on 2026-08-19.
Wikipedia Overview
4C-TFM, also known as TFM-Ariadne or 4C-DOTFM, as well as 4-trifluoromethyl-2,5-dimethoxy-α-ethylphenethylamine, is a serotonin 5-HT2 receptor agonist of the phenethylamine, phenylisobutylamine, and 4C families related to Ariadne (4C-D). It is a close analogue of the psychedelic drugs 2C-TFM and DOTFM, with 2C-TFM having no substitution at the α carbon, DOTFM having an α-methyl group, and 4C-TFM having an α-ethyl group. The drug is a potent agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. It shows similar efficacy as an agonist of these receptors as Ariadne, but shows about 6.4-fold higher potency as a serotonin 5-HT2A receptor agonist in comparison. Like Ariadne, 4C-TFM produces an attenuated head-twitch response relative to the psychedelic drug DOPR, with a similar maximal response as Ariadne. The chemical synthesis of 4C-TFM has been described. 4C-TFM was first described in the scientific literature by Michael Cunningham and colleagues in 2023.
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