Why is "4-Aminopyridine" trending?
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Trend Analysis
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- Date: 2026-03-16 23:03:57
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
4-Aminopyridine (4-AP) is an organic compound with the chemical formula H2NC5H4N. It is one of the three isomeric aminopyridines. It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. It was undergoing Phase III clinical trials as of 2008, and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010. 4-AP has been used as treatment for KCNA2-related disorders with gene mutations that show a clear gain-of-function. Benefits include decreased seizures and improved ataxia, alertness, and cognition. Fampridine is also marketed as Ampyra in the United States by Acorda Therapeutics and as Fampyra in the European Union, Canada, and Australia. In Canada, the medication has been approved for use by Health Canada since February 10, 2012.
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Search Interest Perspective
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Evaluation of the in vitro otoprotective potential of 4-aminopyridine for cisplatin-induced ototoxicity - Frontiers
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Crystal Growth, Mechanical, Thermal and Third Order NLO Characteristics of a Single Crystal of 4-nitroaniline 4-aminopyridine for Optoelectronics Applications - Wiley Online Library
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Repurposed multiple sclerosis drug could help bones heal faster - Medical Xpress
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Orally administered 4-aminopyridine improves clinical signs in multiple sclerosis - National Institutes of Health (.gov)
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Structure-activity relationship studies of four novel 4-aminopyridine K+ channel blockers | Scientific Reports - Nature
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Case Report: Improvement of diplopia due to severe internuclear ophthalmoplegia by 4-aminopyridine documented using a novel virtual reality-based oculography headset - Frontiers
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Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors - Journal of Neuroscience
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Possible new treatment for spinal cord injuries identified in animal studies - Purdue University
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4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice - Nature
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Biogen Idec Issues Statement on U.S. Approval of AMPYRA™ (dalfampridine) - Biogen
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Bilateral Dentate Nuclei Hyperintensities and Response to 4-Aminopyridine in a Patient With Childhood-Onset GAA- FGF14 -Related Ataxia - Neurology® Journals
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Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal Cortex in Vitro - Journal of Neuroscience
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Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression - Nature
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The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs - Frontiers
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State-Dependent Enhancement of Subthreshold A-Type Potassium Current by 4-Aminopyridine in Tuberomammillary Nucleus Neurons - Journal of Neuroscience
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4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6 - Nature
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which triggers exocytosis in excitable and non-excitable cells - Nature
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Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine - Nature
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Effect of 4-aminopyridine on gait in ambulatory spinal cord injuries: a double-blind, placebo-controlled, crossover trial - Nature
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Computational modeling and synthesis of pyridine variants of benzoyl-phenoxy-acetamide with high glioblastoma cytotoxicity and brain tumor penetration - Nature
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Fampridine and Acetazolamide in EA2 and Related Familial EA - Neurology® Journals
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Molecular Medicine Reports - Spandidos Publications
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Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT - Nature
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Pharmacological evidence that potassium channels mediate hydrogen sulfide-induced inhibition of the vasopressor sympathetic outflow in pithed rats - ScienceDirect.com
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uptake: A scanning electrochemical microscopy study of single living cells - PNAS
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Effects of 3,4-diaminopyridine on myasthenia gravis: Preliminary results of an open-label study - Frontiers
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Possible New Treatment for Spinal Cord Injuries Identified in Research Led by PVM Professor - Purdue University College of Veterinary Medicine
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Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors - Nature
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An innovative PET tracer can measure damage from multiple sclerosis in mouse models - UChicago Medicine
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Sciatic nerve injury regeneration in adult male rats using gelatin methacrylate (GelMA)/poly(2-ethy-2-oxazoline) (PEtOx) hydrogel containing 4-aminopyridine (4-AP) - Wiley Online Library
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Potential Treatment for Rare Genetic Epilepsy Discovered - Inside Precision Medicine
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Researchers to study how drug can be repurposed to assess nerve injuries - Penn State Health News
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Status Epilepticus Associated With Dalfampridine in a Patient With Multiple Sclerosis - Psychiatry Online
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Synthesis of novel aryl-substituted 2-aminopyridine derivatives by the cascade reaction of 1,1-enediamines with vinamidinium salts to develop novel anti-Alzheimer agents - Nature
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Drug studied as possible treatment for spinal injuries - Purdue University
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Paralysis team making strides on many fronts - Purdue University
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The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach | Molecular Psychiatry - Nature
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U of A study finds existing drug may speed bone healing process - KGUN 9
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Acorda Therapeutics to Regain Global Commercialization Rights to FAMPYRA® by January 2025 - Business Wire
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Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury - Nature
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Bird pesticide Avitrol is legal, but recent deaths are stoking controversy - National Geographic
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Phase 2 trial of sustained-release fampridine in chronic spinal cord injury - Nature
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Biogen Idec Receives Approval for FAMPYRA in Australia to Improve Walking Ability in Adult Patients with MS - Biogen
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Fampyra/Ampyra May Improve Walking Speed in MS Patients Over Longer Term, Study Says - Multiple Sclerosis News Today
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Drug Improves Mobility for Some MS Patients - University of Rochester Medical Center
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Repurposed Drug May Offer Diagnosis, Treatment for Traumatic Nerve Damage - University of Rochester Medical Center
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Biogen Idec Receives Conditional Approval in the European Union for FAMPYRA® to Improve Walking in Adults with Multiple Sclerosis - Biogen
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Biogen Idec to Present Extensive New Data from Its Robust Multiple Sclerosis Portfolio at ECTRIMS - Biogen
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MS Drug — Ampyra: A New Gait For Independence - abilitymagazine.com
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Beating the Heat With MS Symptoms - National Multiple Sclerosis Society
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Mechanism of Accelerated Current Decay Caused by an Episodic Ataxia Type-1-Associated Mutant in a Potassium Channel Pore - Journal of Neuroscience
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Merz Therapeutics Closes $185M Asset Purchase Agreement with Acorda Therapeutics - Business Wire
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Biogen Idec and Acorda Therapeutics Announce Collaboration Agreement to Develop and Commercialize MS Therapy Fampridine-SR in Markets Outside the U.S. - Biogen
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