Why is "25-hydroxycholesterol" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-11 16:25:47
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
25-hydroxycholesterol entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-11 and was most recently seen on 2026-06-11.
Wikipedia Overview
25-Hydroxycholesterol is a derivative of cholesterol, which plays a role in various biological processes in humans and other species. It is involved in cholesterol metabolism, antiviral process, inflammatory and immune response, and survival signaling pathway. 25-hydroxycholesterol is biosynthesized from cholesterol by adding a hydroxyl group at the position 25-carbon of a steroid nucleus. This reaction is catalyzed by cholesterol 25-hydroxylase, a family of enzymes that use oxygen and a di-iron cofactor to catalyze hydroxylation reaction.
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Trending Topic Today
Search Interest Perspective
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High follicular fluid levels of 25-hydroxycholesterol might lead to increased number of lipid droplets in granulosa cells in polyendocrine metabolic ovarian syndrome (PMOS): a hypothesis - springermedicine.com
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Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics - Wiley Online Library
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CH25H-mediated cholesterol metabolism drives chondrogenic differentiation in adipose-derived stem cells and enhances cartilage repair - Nature
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25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway - Frontiers
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Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling - ahajournals.org
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25-Hydroxycholesterol acts as an amplifier of inflammatory signaling - PNAS
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A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol - Journal of Neuroscience
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25-hydroxycholesterol: an integrator of antiviral ability and signaling - Frontiers
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Oxysterol undersulfation promotes osteoarthritis by fueling chondrocyte lipid accumulation - Nature
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25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production - PNAS
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Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice - Wiley Online Library
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25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor - Nature
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Increased 25-hydroxycholesterol as an indicator for patients with vestibular neuritis - Frontiers
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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients - Nature
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Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response - Nature
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Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses | Scientific Reports - Nature
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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome - Nature
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Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol - Nature
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A novel target to turn cold tumors into hot tumors: lysosomal 25-hydroxycholesterol activates AMPKα and immunosuppressive tumor-associated macrophages - Nature
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25-Hydroxycholesterols in innate and adaptive immunity - Nature
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Molecular basis for the recognition of 24-( S )-hydroxycholesterol by integrin αvβ3 - Nature
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Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma - Nature
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Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice - Nature
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Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function - Nature
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Five-aza-2′-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells - Nature
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Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms - Nature
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25-hydroxysterol mitigates microgravity-induced retinal damage by suppressing microglial inflammation through disrupting lipid raft formation - Nature
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Brain Pathology | ISN Neuropathology Journal - Wiley Online Library
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25-hydroxycholesterol inhibits human papillomavirus infection in cervical epithelial cells by perturbing cytoskeletal remodeling - Wiley Online Library
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Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages - PNAS
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Unveiling the intricate mechanisms behind oxysterol-induced cell death - EurekAlert!
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Cholesterol in viral envelope determines infectivity of SARS-CoV-2 and other coronaviruses - Frontiers
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27-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis - Nature
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Interferon-induced miR-7705 modulates the anti-virus activity of cholesterol 25-hydroxylase - ASM Journals
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Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication - ASM Journals
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A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols - Science | AAAS
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Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts - Nature
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Oxysterols as Reliable Markers of Quality and Safety in Cholesterol Containing Food Ingredients and Products - Frontiers
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Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication - ASM Journals
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Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin - Science | AAAS
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Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion - PNAS
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Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands - PNAS
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deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis - Nature
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From the journals: JLR - American Society for Biochemistry and Molecular Biology
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Large Study Confirms Statins Reduce COVID-19 Severity - dicardiology.com
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New enzyme discovery could boost cancer immunotherapy - Drug Target Review
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Oxysterol-binding proteins: Functions in cell regulation beyond lipid metabolism - ScienceDirect.com
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Researchers Identify a Protein That Blocks HIV - SciTechDaily
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Drug could replace surgery for specific cataracts - insightnews.com.au
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.