Why is "2-Methyl-6-(phenylethynyl)pyridine" trending?
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- Date: 2026-03-16 10:51:51
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Wikipedia Overview
2-Methyl-6-(phenylethynyl)pyridine (MPEP) is a research drug which was one of the first compounds found to act as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5. After being originally patented as a liquid crystal for LCDs, it was developed by the pharmaceutical company Novartis in the late 1990s. It was found to produce neuroprotective effects following acute brain injury in animal studies, although it was unclear whether these results were purely from mGluR5 blockade as it also acts as a weak NMDA antagonist, and as a positive allosteric modulator of another subtype mGlu4, and there is also evidence for a functional interaction between mGluR5 and NMDA receptors in the same populations of neurons. It was also shown to produce antidepressant and anxiolytic effects in animals, and to reduce the effects of morphine withdrawal, most likely due to direct interaction between mGluR5 and the μ-opioid receptor.
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Search Interest Perspective
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The Behavioral Profile of the Potent and Selective mGlu5 Receptor Antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in Rodent Models of Anxiety - Nature
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C-ABP688 as a Probe for Imaging the Metabotropic Glutamate Receptor Subtype 5 - Journal of Nuclear Medicine
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Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice - PNAS
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Metabotropic Glutamate Receptors Differentially Regulate GABAergic Inhibition in Thalamus - Journal of Neuroscience
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Therapeutic potential of mGluR5 targeting in Alzheimer's disease - Frontiers
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A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina - Wiley
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Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs - Frontiers
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Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles - Nature
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Motor behavior induced by bergamot essential oil in experimental tasks is differentially modulated by pretreatment with metabotropic glutamate receptor 2/3 or 5 antagonists - Wiley Online Library
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mGluR5 stimulates gliotransmission in the nucleus accumbens - PNAS
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Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus - Journal of Neuroscience
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mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism - Nature
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Long-Term Depression of NMDA Receptor-Mediated Synaptic Transmission Is Dependent on Activation of Metabotropic Glutamate Receptors and Is Altered to Long-Term Potentiation by Low Intracellular Calcium Buffering - Journal of Neuroscience
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Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases? - Frontiers
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In the Amygdala Anxiolytic Action of mGlu5 Receptors Antagonist MPEP Involves Neuropeptide Y but not GABAA Signaling - Nature
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Intracellular Astrocyte Calcium Waves In Situ Increase the Frequency of Spontaneous AMPA Receptor Currents in CA1 Pyramidal Neurons - Journal of Neuroscience
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mGluR5 Antagonist MPEP Reduces Ethanol-Seeking and Relapse Behavior - Nature
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Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release - Nature
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Improved retinal function in RCS rats after suppressing the over-activation of mGluR5 - Nature
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Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells - Nature
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Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants - Nature
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Targeting metabotropic glutamate receptors for symptomatic and disease-modifying treatment in Parkinson’s disease - Nature
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Retrograde Endocannabinoid Signaling in a Postsynaptic Neuron/Synaptic Bouton Preparation from Basolateral Amygdala - Journal of Neuroscience
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Role of glutamate transporter 1 in the attenuation of alcohol intake - Frontiers
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Postsynaptic scaffold protein Homer 1a protects against traumatic brain injury via regulating group I metabotropic glutamate receptors - Nature
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TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations - PNAS
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The Selective mGlu5 Receptor Antagonist MTEP, Similar to NMDA Receptor Antagonists, Induces Social Isolation in Rats - Nature
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Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats | Scientific Reports - Nature
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Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP - Nature
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Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5 - Nature
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The Selective mGlu5 Receptor Agonist CHPG Inhibits Quinpirole-Induced Turning in 6-Hydroxydopamine-Lesioned Rats and Modulates the Binding Characteristics of Dopamine D2 Receptors in the Rat Striatum Interactions with Adenosine A2a Receptors | N - Nature
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Methamphetamine potentiates HIV-1 gp120-mediated autophagy via Beclin-1 and Atg5/7 as a pro-survival response in astrocytes - Nature
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The Ampakine CX546 Restores the Prepulse Inhibition and Latent Inhibition Deficits in mGluR5-Deficient Mice - Nature
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Review: Galaxy 15000 – Aromaking - vapingpost.com
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