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Between 1836 and 1840, smallpox became widespread across the Great Plains. The epidemic reached its height following the spring of 1837, when an American Fur Company steamboat, the SS St. Peter's, carried infected people and supplies up the Missouri River in the Midwestern United States. The disease spread rapidly to indigenous populations with no natural immunity, causing widespread illness and death across the Great Plains, especially in the Upper Missouri River watershed. More than 17,000 Indigenous people died along the Missouri River alone, with some bands becoming nearly extinct.
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