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1738–1739_North_Carolina_smallpox_epidemic entered the ranking for the first time today at position #. This is its highest position ever recorded.
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-26 and was most recently seen on 2026-06-26.
Between 1738 and 1739, a smallpox epidemic broke out among the Cherokee who resided in the Province of North Carolina, as well as in the Province of South Carolina. The epidemic was most damaging in Eastern North Carolina. The epidemic decimated the Cherokee and Catawba peoples, causing the deaths of about half of each tribe's population. Many other Native tribes were decimated as well. Smaller numbers of European settlers and Africans also died during the epidemic. The depopulation after the epidemic caused the Cherokee to abandon many villages, particularly in Georgia along the Chattooga, Tugaloo, and Chattahoochee rivers. The Cherokee did not begin to recover from their population loss until the end of the 18th century. An estimated 7,700–11,700 died during the epidemic.
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